Aberrant interactions of peripheral measures and neurometabolites with lipids in complex regional pain syndrome using magnetic resonance spectroscopy: A pilot study

Abstract

BackgroundThe aim of this study was to assess peripheral measures and central metabolites associated with lipids using magnetic resonance spectroscopy.ResultsTwelve patients with complex regional pain syndrome (CRPS) and 11 healthy controls participated. Using magnetic resonance spectroscopy, we measured the levels of lipid 13a (Lip13a) and lipid 09 (Lip09) relative to total creatine (tCr) levels in the right and left thalamus. We found negative correlations of Lip13a/tCr in the right thalamus with red blood cells or neutrophils, but a positive correlation between Lip13a/tCr and lymphocytes in the controls. We found negative correlations between Lip09/tCr and peripheral pH or platelets in the controls. There were positive correlations between Lip09a/tCr and myo-inositol/tCr, between Lip13a/tCr and N-acetylaspartate (NAA)/tCr, and between Lip09/tCr and NAA/tCr in healthy controls. On the other hand, there were positive correlations between Lip13a/tCr and Lip09/tCr and urine pH in CRPS patients. There were significant correlations between Lip13a/tCr or Lip09/tCr and different peripheral measures depending on the side of the thalamus (right or left) in CRPS patients.ConclusionThis is the first report indicating that abnormal interactions of Lip13a and Lip09 in the thalamus with peripheral measures and central metabolites may mediate the complex pathophysiological mechanisms underlying CRPS.

Weak neuronal glycolysis sustains cognition and organismal fitness

“…2e), and in vivo 1 H-MRS brain analysis of CamkIIα-Pfkfb3 mice showed increased lipid 13a and lipid 13b signals (Extended Data Fig. 3b), which denotes enhanced abundance of lipid droplets 29,30 . To confirm this, we assessed by western blotting the levels of perilipin 2 (PLIN2), a lipid droplet-coating protein that limits the access of lipases, favouring the accumulation of lipids 31 .…”