Commonalities and differences in abnormal peripheral metabolites between patients with fibromyalgia and complex regional pain syndrome

Jung, Ye Ha; Lee, Won Joon; Lee, Dong Hoon; Lee, Jae Yeon; Moon, Jee Youn; Kim, Yong Chul; Choi, Seong Hee; Kang, Do Hyung

doi:10.1080/00207454.2019.1702542

Cited by 4 publications

(3 citation statements)

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“…[40] The creatinine level tended to be lower in FM patients than healthy controls, and a low creatinine level correlated with high-level affective pain in FM patients. [20] Also, the serum creatinine levels were significantly reduced in FM patients compared to the healthy controls (P = .029) in this study. Thus, a low creatinine level may be a key biomarker of FM pathology and high-level neuroinflammation.…”

Section: Discussionsupporting

confidence: 52%

“…[ 19 ] We previously reported a tendency of low creatinine levels in FM patients. [ 20 ] Thus, we also investigated the relationship between creatinine levels and neuroinflammation, and hypothesized that low creatinine levels may be associated with neuroinflammation in FM patients in this study. We explored various other peripheral measures including CRP using routine blood and urine analysis in FM patients.…”

Section: Introductionmentioning

confidence: 99%

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Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study

et al. 2023

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To identify central metabolites and peripheral measures associated with neuroinflammation in fibromyalgia (FM), we scanned [ 11 C]-(R)-PK11195 positron emission tomography and magnetic resonance spectroscopy in FM patients. We measured associations between neurometabolite levels measured by magnetic resonance spectroscopy and the extent of neuroinflammation inferred by the distribution volume ratios of [ 11 C]-(R)-PK11195 positron emission tomography in 12 FM patients and 13 healthy controls. We also examined the associations between peripheral parameters, such as creatinine and C-reactive protein, and neuroinflammation. In FM patients, we found negative correlations between neuroinflammation and the creatine (Cr)/total creatine (tCr; Cr + phosphocreatine) ratios in the right (r = −0.708, P = .015) and left thalamus (r = −0.718, P = .008). In FM patients, negative correlations were apparent between neuroinflammation and the glutamate/tCr ratio in the right insula (r = −0.746, P = .005). In FM patients, we found negative correlations between neuroinflammation in the left thalamus (r = –0.601, P = .039) and left insula (r = −0.598, P = .040) and the blood creatinine levels. Additionally, we found significant correlations of other peripheral measures with neuroinflammation in FM patients. Our results suggest that both central metabolites, such as Cr and glutamate, and peripheral creatinine and other parameters are associated with neuroinflammation in patients with FM.

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Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: A preliminary study

et al. 2023

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“…Studies have not found elevated serum levels of proinflammatory cytokines (eg, TNF-α) in patients with predominately early CRPS compared with patients with upper extremity fractures or upper extremity pain of other origin (Table).13 One study did report elevated serum levels of osteoprotegerin, a cytokine receptor involved in regulating bone turnover, in patients with CRPS compared with healthy controls and to patients who had normal healing after a long bone fracture (sensitivity = 74%, specificity = 79% for the diagnosis of CRPS).13 Patients with CRPS also have lower levels of serum bilirubin compared with healthy controls. 14 Two groups have shown that approximately 70% of patients with CRPS have the presence of antiautonomic immunoglobulin G serum antibodies that activate β-2 adrenergic or M2 muscarinic receptors. 13 With regard to metabolites, changes in plasma levels of amino acids involved in glutamate receptor activation were reported in patients with CRPS; specifically, increased levels of glutamate and aspartate, decreased levels of tryptophan, an increase in the kynurenine to tryptophan ratio, and a decrease in arginine levels were reported.…”

Section: Molecular Biomarkersmentioning

confidence: 99%