Aberrant expression of β- and γ-catenin is an independent prognostic marker in oral squamous cell carcinoma

G, Ueda; Sunakawa, Hajime; Nakamori, Kenji; Tanaka, Shinya; Tsuhako, Wakatsu; Tamura, Yasuaki; Kosugi, Tadayoshi; Sato, Noriyuki; Ogi, Kazuhiro; Hiratsuka, Hiroyoshi

doi:10.1016/j.ijom.2005.07.023

Cited by 59 publications

(55 citation statements)

References 28 publications

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“…Therefore, it was not detected a positive relationship of this protein with the tumor metastatic potential, which corroborates the results of previous studies 1,5,10,11 . However, some studies were able to establish a statistically significant relationship between the decreased ß-catenin expression with metastasis [12][13][14] .…”

Section: Resultsmentioning

confidence: 99%

Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma

Freitas

Silveira

et al. 2010

Acta Cir. Bras.

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Purpose: It has been reported that the oral squamous cell carcinoma (OSCC) in tongue shows a more infiltrative profile, aggressive clinical course and poor prognosis, which may be related to a higher metastatic potencial. The aim of the present study was to assess the expression of ß-catenin in OSCC of the tongue and its correlation with tumor metastasis. Methods: Twenty four cases were selected and divided in two groups: metastatic group (n=12) and non-metastatic group (n=12). A semi-quantitative analysis of the ß-catenin expression was performed in the invasive tumor front and cases were graded as follows: negative (score 0), positive (score +), and strongly positive (score ++). Results: It was detected that 33%, 50% and 17% of the cases in metastatic group were scored 0, + and ++, respectively, and the non-metastatic group showed that 42% were scored "0", 33% scored + and 25% scored ++. Statistical analysis showed no diference between the studied groups. Conclusions: Based on these results, it can be concluded that the immunoexpression of ß-catenin does not represent a valuable tool to predict metastatic potencial of OSCC in tongue. Key words: Carcinoma, Squamous Cell. Tongue. Neoplasm Metastasis. beta Catenin. Cell Adhesion. RESUMOObjetivo: O carcinoma de células escamosas (CCE) quando presente em língua exibe aspecto mais infiltrativo, curso clínico agressivo e prognóstico desfavorável. Tais características podem associar-se com maior potencial metastático. O presente trabalho teve como meta investigar a expressão de ß-catenina em CCE de língua e sua relação com o desenvolvimento de metástases. Métodos: Foram selecionados 24 casos de CCE em língua e divididos em dois grupos: grupo metastático (n=12) e grupo sem metástase (n=12). Realizou-se uma análise semi-quantitativa da imunoexpressão da ß-catenina no fronte invasivo tumoral e sendo considerada como negativa, positiva e fortemente positiva, atribuindo-se os escores, "0", "+" e "++", respectivamente. Resultados: A expressão de ß-catenina apresentou, no grupo metastático, escore "0" em 33% dos casos, escore "+" em 50% dos casos e escore "++" em 17% dos casos; e, no grupo sem metástase, escore "0" em 42% dos casos, escore "+" em 33% dos casos e escore "++" em 25% dos casos. A análise estatística não demonstrou nenhuma diferença signficativa entre a expressão da proteína nos dois grupos. Conclusão: Diante destes resultados, concluiu-se que a expressão da ß-catenina não constitui um método eficaz, isoladamente, para predizer o potencial metastático do CCE em língua. Descritores: Carcinoma de Células Escamosas. Língua. Metástase Neoplásica. beta Catenina. Adesão Celular.

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Section: Resultsmentioning

confidence: 99%

Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma

Freitas

Silveira

et al. 2010

Acta Cir. Bras.

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“…The absence or low expression of E-cadherin or b-catenin was significantly associated with some clinicopathological parameters and with a poor prognosis in some publications, but not in others. [19][20][21][22][23][51][52][53][54] The reason for these contradictory results may be that the standard used to evaluate the immunostaining and the definition of reduced or overexpression is quite variable. Alternatively, the tumour cells in oral squamous cell carcinoma patients may exhibit a heterogeneous cell population with variable behaviour.…”

Section: Discussionmentioning

confidence: 99%

“…To date, the results from studies examining the correlation between E-cadherin and b-catenin expression and the prognosis of oral squamous cell carcinoma patients have been controversial. [19][20][21][22][23][51][52][53][54] Therefore, further studies with a large patient population are needed to examine the role of E-cadherin and b-catenin using standardised methods to evaluate the immunostaining and with standardised definitions of reduced or overexpression.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of vimentin and aberrant expression of E-cadherin/β-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome

et al. 2010

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Oral squamous cell carcinoma is a challenging oncology problem. A reliable biomarker for metastasis or high-risk prognosis in oral cancer patients remains undefined. Using quantitative immunohistochemistry, we examined the expression of vimentin, E-cadherin, and b-catenin in 83 oral squamous cell carcinoma patients, and the relationships between the expression of these markers and specific clinicopathological features were analysed. The high expression of vimentin was observed in 23 of 43 (53%) tumours from patients who eventually developed a recurrent tumour and was associated with recurrence and death (Po0.001 and o0.001, respectively). The decreased expression of E-cadherin was observed in 36 of 43 (84%) tumours from patients who eventually developed a recurrent tumour and was also associated with recurrence and death (Po0.001 and o0.001, respectively). Although no correlation between b-catenin expression in whole-tumour sections and clinicopathological features was observed, decreased b-catenin expression at the tumour invasive front was closely associated with recurrence and death (P ¼ 0.002 and 0.002, respectively). The expression of vimentin and that of E-cadherin were associated with survival and were independent prognostic factors in univariate and multivariate analyses. Our data show that the overexpression of vimentin was closely associated with recurrence and death in oral squamous cell carcinoma patients. The combination of the upregulation of vimentin and aberrant expression of E-cadherin/b-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. Modern Pathology (2010) 23, 213-224; doi:10.1038/modpathol.2009 published online 13 November 2009 Keywords: vimentin; oral squamous cell carcinoma; immunohistochemistry Oral cancer is the sixth most frequently occurring cancer worldwide, accounting for 3-5% of all malignancies in both sexes.1,2 Over 90% of all oral carcinomas are classified as oral squamous cell carcinoma, which remains a challenging oncology problem.3 Although early-stage oral squamous cell carcinoma can be treated or cured, the prognosis for advanced oral squamous cell carcinoma (stage III and IV) is poor. The treatment of oral squamous cell carcinoma is usually based on surgery or radiation, with or without concomitant chemotherapy. Despite these advanced therapeutic strategies, the 5-year survival rate of oral squamous cell carcinoma (B50%) has not increased over the past four decades.3-5 Local or regional relapse and cervical lymph node metastasis are the most prevalent

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“…Downregulation of T-cadherin is believed to contribute to tumour invasiveness in basal-cell carcinomas (Takeuchi et al, 2002). Similarly, cancer patients with loss of g-catenin expression are considered a high-risk group for tumour metastasis and poor prognosis (Clairotte et al, 2006;Ueda et al, 2006).…”

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confidence: 99%

Cellular functions of 14-3-3ζ in apoptosis and cell adhesion emphasize its oncogenic character

et al. 2007

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Aberrant expression of β- and γ-catenin is an independent prognostic marker in oral squamous cell carcinoma

Cited by 59 publications

References 28 publications

Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma

Correlation of β-catenin expresssion and metastasis in tongue squamous cell carcinoma

Upregulation of vimentin and aberrant expression of E-cadherin/β-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome

Cellular functions of 14-3-3ζ in apoptosis and cell adhesion emphasize its oncogenic character

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