Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer

Zhu, Chenhong; Xiao, Deshuang

doi:10.1097/md.0000000000023133

Cited by 3 publications

(3 citation statements)

References 19 publications

(20 reference statements)

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“…Many studies have reported that the abnormal expression of BEX family genes was related to the development and prognosis of tumors, such as GBM, gastric cancer, colorectal cancer, hepatocellular carcinoma, lung cancer, and breast cancer (11,(25)(26)(27)(28). Here, through the analysis of GBM samples in TCGA database, we once again verify that, except for BEX3, BEX family genes were significantly downregulated in GBM.…”

Section: Aberrant Expression Of Bex Family Genes In Glioblastoma Mult...supporting

confidence: 62%

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Comprehensive Analysis of the Brain-Expressed X-Link Protein Family in Glioblastoma Multiforme

Aisa

Tan

et al. 2022

Front. Oncol.

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Glioblastoma multiforme (GBM) is the most common, malignant, and deadly primary brain tumor in adults. Brain-expressed X-link (BEX) protein family is involved in tumorigenesis. Here, we have explored the biological function and the prognostic value of the BEX family in GBM. Differentially expressed BEX genes between GBM and normal tissue were screened by using The Cancer Genome Atlas (TCGA) database. Univariate and multivariate Cox regression analyses identified the prognosis‐related genes BEX1, BEX2, and BEX4, which were involved in the regulation of immune response. The results of correlation analysis and protein–protein interaction network (PPI network) showed that there was a significant correlation between the BEX family and TCEAL family in GBM. Furthermore, the expression of transcription elongation factor A (SII)-like (TCEAL) family is generally decreased in GBM and related to poor prognosis. With the use of the least absolute shrinkage and selection operator (LASSO) Cox regression, a prognostic model including the BEX family and TCEAL family was built to accurately predict the likelihood of overall survival (OS) in GBM patients. Therefore, we demonstrated that the BEX family and TCEAL family possessed great potential as therapeutic targets and prognostic biomarkers in GBM. Further investigations in large‐scale, multicenter, and prospective clinical cohorts are needed to confirm the prognostic model developed in our study.

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Section: Aberrant Expression Of Bex Family Genes In Glioblastoma Mult...supporting

confidence: 62%

“…Members of the BEX family have also reported a prognostic correlation in other tumors, such as gastric cancer and liver cancer ( 27 , 29 ). In our study, it can also be found that the downregulation of the BEX genes was correlated with the worse prognosis (except for BEX5).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Brain-Expressed X-Link Protein Family in Glioblastoma Multiforme

Aisa

Tan

et al. 2022

Front. Oncol.

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“…24 BEX family proteins are known to play a role in neuronal development and recent studies suggest a role in cancers. [25][26][27][28][29] BEX1 suppressed tumor cell growth of esophageal squamous cell cancer, colorectal cancer, acute myeloid leukemia, oral squamous cell carcinoma, malignant glioma. [30][31][32][33][34] But in lung adenocarcinoma, malignant pleural mesothelioma and GBM, BEX1 promoted tumor cell growth.…”

Section: Discussionmentioning

confidence: 99%

Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer

Sun

Zhao

2022

Cancer Inform

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Background: Cancer is the leading cause of death in the world. The mechanism is not fully elucidated and the therapeutic effect is also unsatisfactory. In our study, we aim to find new target gene in pan-cancer. Methods: Differently expressed genes (DEGs) was screened out in various types of cancers from GEO database. The expression of DEG (TCEAL2) in tumor cell lines, normal tissues and tumor tissues was calculated. Then the clinical characteristics, DNA methylation, tumor infiltration and gene enrichment of TCEAL2 was studied. Results: TCEAL2 expressions were down-regulated in most cancers. Its expression and methylation were positively or negatively associated with prognosis in different cancers. The tumor infiltration results revealed that TCEAL2 was significantly related with many immune cells especially NK cells and immune-related genes in majority cancers. Furthermore, tau protein and tubulin binding were involved in the molecular function mechanisms of TCEAL2. Conclusion: TCEAL2 may be a novel prognostic marker in different cancers and may affect tumor through immune infiltration.

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The post‐stroke young adult brain has limited capacity to re‐express the gene expression patterns seen during early postnatal brain development

Ruscu,

Capitanescu,

Rupek

et al. 2024

Brain Pathology

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The developmental origins of the brain's response to injury can play an important role in recovery after a brain lesion. In this study, we investigated whether the ischemic young adult brain can re‐express brain plasticity genes that were active during early postnatal development. Differentially expressed genes in the cortex of juvenile post‐natal day 3 and the peri‐infarcted cortical areas of young, 3‐month‐old post‐stroke rats were identified using fixed‐effects modeling within an empirical Bayes framework through condition‐specific comparison. To further analyze potential biological processes, upregulated and downregulated genes were assessed for enrichment using GSEA software. The genes showing the highest expression changes were subsequently verified through RT‐PCR. Our findings indicate that the adult brain partially recapitulates the gene expression profile observed in the juvenile brain but fails to upregulate many genes and pathways necessary for brain plasticity. Of the upregulated genes in post‐stroke brains, specific roles have not been assigned to Apobec1, Cenpf, Ect2, Folr2, Glipr1, Myo1f, and Pttg1. New genes that failed to upregulate in the adult post‐stroke brain include Bex4, Cd24, Klhl1/Mrp2, Trim67, and St8sia2. Among the upregulated pathways, the largest change was observed in the KEGG pathway “One carbon pool of folate,” which is necessary for cellular proliferation, followed by the KEGG pathway “Antifolate resistance,” whose genes mainly encode the family of ABC transporters responsible for the efflux of drugs that have entered the brain. We also noted three less‐described downregulated KEGG pathways in experimental models: glycolipid biosynthesis, oxytocin, and cortisol pathways, which could be relevant as therapeutic targets. The limited brain plasticity of the adult brain is illustrated through molecular and histological analysis of the axonal growth factor, KIF4. Collectively, these results strongly suggest that further research is needed to decipher the complex genetic mechanisms that prevent the re‐expression of brain plasticity‐associated genes in the adult brain.

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Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer

Cited by 3 publications

References 19 publications

Comprehensive Analysis of the Brain-Expressed X-Link Protein Family in Glioblastoma Multiforme

Comprehensive Analysis of the Brain-Expressed X-Link Protein Family in Glioblastoma Multiforme

Transcription Elongation Factor A (SII)-Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer

The post‐stroke young adult brain has limited capacity to re‐express the gene expression patterns seen during early postnatal brain development

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