Abdominal unicentric Castleman's disease: a case report

Bradai, Samir; Khsiba, A; Nakhli, Abdelwaheb; Mahmoudi, Moufida; Mohamed, Asma Ben; Chaabane, Abir; Chelbi, Emna; Mona, Medhioub; Hamzaoui, Lamine; Azouz, Mousadek

doi:10.11604/pamj.2021.38.339.28859

Cited by 3 publications

(2 citation statements)

References 10 publications

(23 reference statements)

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“…Patients with MCD must continue to be monitored due to the risk of progression to lymphoma [4]. Unicentric Castleman's disease tends to stay localized to one lymph node, does not seem to require any pharmacologic treatment, and is best treated with excision [2,5].…”

Section: Discussionmentioning

confidence: 99%

“…Multicentric Castleman's disease, a systemic disease involving multiple body areas, is best treated with monoclonal antibodies, such as rituximab and siltuximab [ 2 ]. Patients with MCD must continue to be monitored due to the risk of progression to lymphoma [ 4 ]. Unicentric Castleman's disease tends to stay localized to one lymph node, does not seem to require any pharmacologic treatment, and is best treated with excision [ 2 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

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Unicentric Castleman’s Disease Presenting As Back Pain

Buntic¹,

Brown²,

Nisar³

et al. 2022

Cureus

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Castleman's disease is a rare disorder caused by a polyclonal proliferation of B lymphocytes and plasma cells. Half of all cases of multicentric Castleman's disease are associated with HIV or Kaposi's Sarcoma. Typically, unicentric Castleman's disease presents as an enlarged thoracic lymph node but can present in multiple other body areas, such as the head and neck. This case report presents a rare large extrathoracic mass causing back pain in a 71-year-old man.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Unicentric Castleman’s Disease Presenting As Back Pain

Buntic¹,

Brown²,

Nisar³

et al. 2022

Cureus

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Unicentric Mesenteric Castleman Disease in an Adolescent: A Case Report

Khazaei Nasirabadi,

Akbari,

Soltani

2024

Shiraz E-Med J

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Introduction: Castleman's disease is a rare nonclonal lymphoproliferative disorder of unknown etiology that most commonly affects the mediastinum. It is classified into two clinical subtypes: A localized (unicentric) subtype and a multifocal (multicentric) subtype. This case report presents an adolescent with unicentric mesenteric Castleman's disease, which is very rare. Case Presentation: A 14-year-old girl presented to our center with chronic left flank pain. She also reported frequent episodes of small-volume vaginal bleeding outside her menstrual period. Initially, she was treated for several weeks with a possible diagnosis of dysmenorrhea due to an ovarian cyst. However, due to the lack of response to treatment and persistent symptoms, further investigation was conducted. Abdominal and pelvic ultrasonography revealed a round, hypoechoic, and heterogeneous mass measuring 22 × 35 mm in the left mesentery with regular margins. Pathological examination confirmed Castleman's disease of the hyaline-vascular type. The patient was discharged in good general condition and with stable vital signs. During follow-up, her abdominal symptoms and bleeding resolved, and no lesions were detected on ultrasonography and CT scans at 6 and 12 months. Conclusions: Mesenteric Castleman's disease is rare and presents a diagnostic challenge. This disease should be included in the differential diagnosis of abdominal tumors, even in symptomatic cases. The treatment of choice for unicentric cases is surgery.

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Mesenteric Castleman Disease Mimicking Neuroendocrine Tumor

K A,

Kota,

Mudigonda

et al. 2024

Cureus

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Castleman disease (CD) is a benign lymphoproliferative disorder of unknown etiology, which can involve any part of the body. CD can involve a single lymph node (unicentric) or multiple lymph nodes (multicentric) of which unicentric CD is the most common type. The unicentric CD is usually localized, asymptomatic, and often appears as an incidental mass on radiographs, whereas multicentric CD is characterized by systemic involvement. Mesenteric involvement of CD is very rare. In this article, we present a case of the unicentric CD of small bowel mesentery, which mimicked a neuroendocrine tumor preoperatively.

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Abdominal unicentric Castleman's disease: a case report

Cited by 3 publications

References 10 publications

Unicentric Castleman’s Disease Presenting As Back Pain

Unicentric Castleman’s Disease Presenting As Back Pain

Unicentric Mesenteric Castleman Disease in an Adolescent: A Case Report

Mesenteric Castleman Disease Mimicking Neuroendocrine Tumor

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