Abdominal pain and asthenia as common clinical features in hospitalized children for giardiasis

Almirall, Pedro; Núñez, Fidel A.; Bello, Janet; González, Odalys M.; Sánchez‐Fernández, Raquel; Escobedo, Ángel A.

doi:10.1016/j.actatropica.2013.05.005

Cited by 14 publications

(7 citation statements)

References 19 publications

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“…Morbidities associated with Giardia have been gradually established over the past decades, including extra-intestinal symptoms and long-term consequences (60)(61)(62). A cross-sectional study examined the role of giardiasis in the development of growth and psychomotor, suggesting an adverse impact of Giardia intestinalis infection (63).…”

Section: Discussion and Perspectivementioning

confidence: 99%

A systematic review of human giardiasis in Bangladesh: public health perspective

Hossain¹,

Rashid²,

Noor³

et al. 2020

Preprint

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Background: Giardiasis identified as a leading cause of gastrointestinal pathogen in young children worldwide, is also common in Bangladesh. There has been an emerging evidence of an association between giardiasis and child growth. This systematic review focuses only on Bangladeshi children. Prevalence of giardiasis with its adverse health effects and the advancement of diagnosis has been reviewed.Methods: A broad review of literature, electronic databases, and books within the time frame of 1970 and 2019 has been searched. Data published on giardiasis prevalence, outcomes (child growth, intestinal permeability, and diarrhea) and advances of diagnosis in Bangladesh has been searched.Results: Both assemblages A and B genotypes of Giardia lamblia are responsible for human giardiasis in Bangladesh. Recent studies on Bangladeshi children suggested Giardia species infections has an adverse impact on poor child growth which have further characterized associations with altered gut epithelial barrier dysfunction, as well as diarrhea. Indeed emerging evidence indicates the key consequence of Giardia colonization is nutrient malabsorption. Conclusions: In Bangladesh giardiasis remains a major public health concern, especially in children age <5 years but is considered as a neglected disease. In order to reduce the burden of giardiasis in developing countries such as Bangladesh, more focus is require to include this disease in public health policies.

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Section: Discussion and Perspectivementioning

confidence: 99%

A systematic review of human giardiasis in Bangladesh: public health perspective

Hossain¹,

Rashid²,

Noor³

et al. 2020

Preprint

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“…It is a flagellated protozoan parasite that infects the small intestine of humans and other mammals producing the diarrheal disease giardiasis [ 1 ]. This infection has worldwide distribution and is highly prevalent in developing countries [ 2 , 3 , 4 , 5 ]; it affects young children, primarily. Several drugs are available for treatment; unfortunately, all of them present variable efficacies and undesirable side effects [ 6 , 7 , 8 , 9 ], and some strains of Giardia have shown resistance towards common drugs.…”

Section: Introductionmentioning

confidence: 99%

Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides

et al. 2017

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Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects. Bursera fagaroides has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of four podophyllotoxin-type lignans from Bursera fagaroides var. fagaroides, namely, 5′-desmethoxy-β-peltatin-A-methylether (5-DES), acetylpodophyllotoxin (APOD), burseranin (BUR), and podophyllotoxin (POD). All lignans affected the Giardia adhesion and electron microscopy images revealed morphological alterations in the caudal region, ventral disk, membrane, and flagella, to different extents. Only 5-DES, APOD, and POD caused growth inhibition. Using the Caco-2 human cell line as a model of the intestinal epithelium, we demonstrated that APOD displayed direct antigiardial killing activity and low toxicity on Caco-2 cells. This finding makes it an attractive potential starting point for new antigiardial drugs.

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“…Clinical giardiasis in some countries, such as Cuba, has been reported as a common reason for hospitalization in pediatric hospitals in Havana, the capital city, where [18][19][20][21], according to a study of risk factors for Giardia infection among hospitalized children, it appears that, at least at the individual level, giardiasis-prevention activities in Havana should be focused on health education to improve personal hygiene and food related practices [20].…”

Section: Discussionmentioning

confidence: 99%

Potential impact of macroclimatic variability on the epidemiology of giardiasis in three provinces of Cuba, 2010–2012

Escobedo

Almirall

Rumbaut

et al. 2015

Journal of Infection and Public Health

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Climate change and variability are common phenomena affecting various infectious diseases. Many studies have been performed on vector-borne diseases; however, few studies have addressed such influences on intestinal parasitic diseases (e.g., giardiasis). In this study, using nonlinear Poisson regression models, we assessed the potential associations between macroclimatic variation and giardiasis cases in children and school workers from three provinces of Cuba in the context of large sampling and parasitological assessment. Between 2010 and 2012, 293,019 subjects were assessed, resulting in 6357 positive for Giardia (216.95 cases/10,000 pop.; 95%CI 211.7-222.2). The variation in time for those giardiasis rates ranged from 35.8 to 525.8 cases/10,000 pop. Nonlinear Poisson regression models between the ONI index and the giardiasis incidence indicated a significant association (p<0.01). With lower values of ONI, lower incidence of giardiasis was observed at Havana (pseudo r(2)=0.0576; p<0.001) and Guantánamo (pseudo r(2)=0.0376; p<0.001). Although these results are preliminary and the magnitude of association is not higher, the results were of statistical significance. This result indicates the need to assess in detail in further studies the impact of additional macroclimatic and microclimatic variables on the epidemiology of this still important intestinal parasitic disease, not only in Cuba but also in other countries of the Caribbean and Latin American region.

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Abdominal pain and asthenia as common clinical features in hospitalized children for giardiasis

Cited by 14 publications

References 19 publications

A systematic review of human giardiasis in Bangladesh: public health perspective

A systematic review of human giardiasis in Bangladesh: public health perspective

Antigiardial Activity of Podophyllotoxin-Type Lignans from Bursera fagaroides var. fagaroides

Potential impact of macroclimatic variability on the epidemiology of giardiasis in three provinces of Cuba, 2010–2012

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