Abdominal obesity validates the association between elevated alanine aminotransferase and newly diagnosed diabetes mellitus

Plasma Levels of Alanine Aminotransferase in the First Trimester Identify High Risk Chinese Women for Gestational Diabetes

“…A cross-sectional study from northern Taiwan involving 1308 male workers aged 22 to 63 years 18 , observed that obesity and elevated ALT had a synergistic effect on insulin resistance (S: 2.1, 95% CI: 1.01–4.3). In another study from middle Taiwan including 5499 subjects, co-occurrence of obesity and elevated ALT was associated with higher odds for diabetes risk compared to subjects with only one of the two risk factors 32 . Compared to the non-obese group with ALT ≤ 40 U/L, the obese and ALT ≤ 40 U/L (adjusted OR: 1.73, 95%CI: 1.08–2.77), the obese and ALT 41–80 U/L (adjusted OR: 2.06, 1.20–3.55) , the obese and ALT 81–120 U/L [adjusted OR: 3.07, 1.38–6.84) and the obese and ALT > 120 U/L (adjusted OR: 7.44, 3.04–18.18) were all associated with increased risks of diabetes 32 .…”

“…In another study from middle Taiwan including 5499 subjects, co-occurrence of obesity and elevated ALT was associated with higher odds for diabetes risk compared to subjects with only one of the two risk factors 32 . Compared to the non-obese group with ALT ≤ 40 U/L, the obese and ALT ≤ 40 U/L (adjusted OR: 1.73, 95%CI: 1.08–2.77), the obese and ALT 41–80 U/L (adjusted OR: 2.06, 1.20–3.55) , the obese and ALT 81–120 U/L [adjusted OR: 3.07, 1.38–6.84) and the obese and ALT > 120 U/L (adjusted OR: 7.44, 3.04–18.18) were all associated with increased risks of diabetes 32 . These findings reiterate the importance of using multiple risk factors to identify high risk subjects.…”

The relationship of alanine aminotransferase to metabolic syndrome in a Korean population

“…A number of studies have demonstrated that the prevalence of elevated alanine aminotransferase (ALT), widely used as a marker of liver damage (5), is higher in individuals with type 2 diabetes and MS (6). In addition, elevated ALT is independently related to the future risk of MS components such as obesity and diabetes (7). Furthermore, increased ALT is associated with diabetes-related morbidity and mortality as well as cardiovascular mortality (8).…”