Abdominal obesity can induce both systemic and follicular fluid oxidative stress independent from polycystic ovary syndrome

The association of thiol/disulphide homeostasis and lipid accumulation index with cardiovascular risk factors in overweight adolescents with polycystic ovary syndrome

“…We suggest that this may be directly related with overweight status since Nasiri et al . demonstrated that abdominal obesity in particular induces both local and systemic oxidative stress in PCOS and also in non‐PCOS patients . However, if being overweight it was the only factor influencing oxidative stress, then the overweight non‐PCOS group in our study would be expected to have similar thiol levels to the overweight PCOS group, but this was not the case.…”

“…We suggest that this may be directly related with overweight status since Nasiri et al demonstrated that abdominal obesity in particular induces both local and systemic oxidative stress in PCOS and also in non-PCOS patients. 40 However, if being overweight it was the only factor influencing oxidative stress, then the overweight non-PCOS group in our study would be expected to have similar thiol levels to the overweight PCOS group, but this was not the HOMA-IR; homeostasis model assessment of insulin resistance, LAP index; lipid accumulation product index, -SH; Native Thiol, -SS+-SH; total thiol, PPV; Positive predictive value, NPV; Negative predictive value. *P < 0Á05 is statistically significant.…”

The Influence of Oxidative Stress in Inflammatory Process and Insulin Resistance in Obese Women with Polycystic Ovary Syndrome

“…It was also evidenced in this group increased total testosterone and fasting insulin and a decrease in progesterone levels, characterizing hyperandrogenism, hyperinsulinemia and chronic anovulation, which are frequent changes in PCOS patients [6,7,25].…”

“…Studies have shown that a high percentage of patients with PCOS, even the non-obese, have an accumulation of excessive visceral fat [6,9]. It is suggested that this increased accumulation of fat in the abdominal region in women with PCOS may promote a dysfunction of adipose tissue [14], increasing IR [15] and hyperandrogenism [17], evidenced by the increase in total testosterone.…”

“…Approximately 80% of women with PCOS present IR [6], compared with only 10% to 25% of individuals in the general population [7], associated with hyperinsulinemia and it may occur regardless of body mass index (BMI) and degree of adiposity [8]. Some studies support the hypothesis that IR influences in the pathogenesis of PCOS, acting as integration agent between metabolic and androgenic abnormalities [2,3,5].…”