Abdominal diffusion mapping with use of a whole-body echo-planar system.

Müller, Markus; Prasad, Pottumarthi V.; Siewert, Bettina; Nissenbaum, Michael A.; Raptopoulos, V.; Rr, Edelman

doi:10.1148/radiology.190.2.8284402

Cited by 225 publications

(189 citation statements)

References 0 publications

Supporting

Mentioning

160

Contrasting

Unclassified

Order By: Relevance

“…In contrast, water molecules move more freely in cystic or necrotic tissues and the water protons ADC is defined freely. As a result DWI provides information about cellularity and cellular membrane integrity, and even microcapillary perfusion The development of echoplanar imaging (EPI), a type of fast MRI method, has shown that, diffusion weighted MRI can be used to evaluate abdominal organs 18,19 . The diffusion properties of tissues are related to the interstitial free fluid and amount of permeability.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of diffusion weighted MRI and ADC in differential diagnosis of cavernous hemangioma of the liver

et al. 2016

View full text Add to dashboard Cite

Aims: To investigate the use of diffusion weighted magnetic resonance imaging (DWI) and the apparent diffusion coefficient (ADC) values in the diagnosis of hemangioma. Materials and methods:The study population consisted of 72 patients with liver masses larger than 1 cm (72 focal lesions). DWI examination with a b value of 600 s/mm 2 was carried out for all patients. After DWI examination, an ADC map was created and ADC values were measured for 72 liver masses and normal liver tissue (control group). The average ADC values of normal liver tissue and focal liver lesions, the "cut-off " ADC values, and the diagnostic sensitivity and specificity of the ADC map in diagnosing hemangioma, benign and malignant lesions were researched. Results: Of the 72 liver masses, 51 were benign and 21 were malignant. Benign lesions comprised 38 hemangiomas and 13 simple cysts. Malignant lesions comprised 9 hepatocellular carcinomas, and 12 metastases. The highest ADC values were measured for cysts (3.782±0.53×10-3 mm 2 /s) and hemangiomas (2.705±0.63×10 -3 mm 2 /s). The average ADC value of hemangiomas was significantly higher than malignant lesions and the normal control group (p<0.001). The average ADC value of cysts were significantly higher when compared to hemangiomas and normal control group (p<0.001). To distinguish hemangiomas from malignant liver lesions, the "cut-off " ADC value of 1.800×10-3 mm 2 /s had a sensitivity of 97.4% and a specificity of 90.9%. To distinguish hemangioma from normal liver parenchyma the "cut-off " value of 1.858×10 -3 mm 2 /s had a sensitivity of 97.4% and a specificity of 95.7%. To distinguish benign liver lesions from malignant liver lesions the "cut-off " value of 1.800×10-3 mm 2 /s had a sensitivity of 96.1% and a specificity of 90.0%. Conclusion: DWI and quantitative measurement of ADC values can be used in differential diagnosis of benign and malignant liver lesions and also in the diagnosis and differentiation of hemangiomas. When dynamic examination cannot distinguish cases with vascular metastasis and lesions from hemangioma, DWI and ADC values can be useful in the primary diagnosis and differential diagnosis. The technique does not require contrast material, so it can safely be used in patients with renal failure .

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnostic value of diffusion weighted MRI and ADC in differential diagnosis of cavernous hemangioma of the liver

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Because of this limitation, DW-MRI was previously only used for brain imaging until the development of fast MRI techniques. The development of echo planar imaging (EPI), one of the fast MRI techniques, eliminated the long imaging time of conventional sequences and the associated artifacts, thus making DW-MRI usable for abdominal examinations (8)(9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

The value of diffusion weighted MR imaging and apparent diffusion coefficient quantification in the diagnosis of perforated and non-perforated appendicitis

Avcu

Çetin²,

Arslan³

et al. 2012

Diagn Interv Radiol

View full text Add to dashboard Cite

ORIGINAL ARTICLE PURPOSE We aimed to evaluate the effectiveness of diffusion-weighted magnetic resonance imaging (DW-MRI) and apparent diffusion coefficient (ADC) values in the diagnosis of acute appendicitis and differentiation of perforated and nonperforated appendicitis cases, with histopathologic correlation. MATERIALS AND METHODSSixty consecutive patients (34 males, 26 females; mean age, 35.6±15.5 years; range, 17-83 years) with a presumptive diagnosis of acute appendicitis were included in this prospective study. With a 1.5 Tesla MRI unit, DW-MRI examinations were performed with b values of 50, 400, and 800 s/mm 2 . The mean ADC values of case and control groups, as well as in perforated and nonperforated groups were compared. RESULTSOf the 60 cases, 44 had a radiological diagnosis of acute appendicitis, and 16 were regarded as normal. Of the 40 patients who underwent surgical operation, 12 had a histopathological diagnosis of perforated appendicitis, and 28 had nonperforated appendicitis. Mean ADC value in patients with acute appendicitis (1.01±0.26×10 -3 mm 2 /s) was lower than the control group (1.85±0.13×10 -3 mm 2 /s) (P < 0.001). Mean ADC value of the perforated group (0.79±0.19×10 -3 mm 2 /s) was lower than the nonperforated group (1.11±0.22×10 -3 mm 2 /s) (P < 0.001). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy rate of DW-MRI in the diagnosis of acute appendicitis were 97.5%, 100%, 97.5%, 100%, and 98.1%, respectively. CONCLUSION DW-MRI and ADC quantification are effective in the diagnosis of acute appendicitis, both in perforated and nonperforated cases. Magnetic resonance imaging (MRI) is the radiological imaging technique offering the highest soft tissue contrast resolution. Currently, in addition to conventional MRI, other MRI techniques are commonly and routinely used, including diffusion-weighted MRI (DW-MRI). DW-MRI is a functional imaging technique that relies on the measurement of the accelerated or slowed microscopic diffusion movements of protons of water molecules. The images are obtained in short interval times and without the requirement for any contrast medium (1).Recently, studies have reported the use of DW-MRI to show active inflammatory lesions in the bowel. In these reports, the mean apparent diffusion coefficient (ADC) of the inflamed bowel segments were compared with the ADC of normal segments, and statistically significant difference was demonstrated (1, 2). Only one study has been investigated the use of DW-MRI for the diagnosis of patients with acute appendicitis (3). However, this study did not focus on the differential diagnosis of perforated and nonperforated appendicitis cases.The aim of this study was to evaluate the effectiveness of DW-MRI and quantitative measurement of ADC values in the diagnosis of acute appendicitis, and in the differentiation between perforated and nonperforated appendicitis cases, with histopathologic correlation. Materials and methods Patient selectionThis prospective study was performed betw...

show abstract

“…Diffusion-weighted imaging (DWI) allows visualization of microscopic water diffusion in biological tissues [2][3][4][5] , and has been applied to head and neck lesions. Many researchers have applied echo-planar imaging (EPI) to DWI of head and neck lesions, as well as diagnosis of diseases of the central nerve system.…”

Section: Introductionmentioning

confidence: 99%

“…The ADC can be useful in characterizing both normal and pathological tissue as it reflects microscopic water diffusion and tissue perfusion in biologic tissues [2][3][4][5] . In many studies, linear regression and gradient b factors of 0 and 1000 sec/mm 2 have been applied to ADC measurement [7][8][9][11][12][13][14]17,18 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of various methods for quantification of apparent diffusion coefficient of head and neck lesions with HASTE diffusion-weighted MR imaging

Sakamoto

Sasaki

Otonari-Yamamoto

et al. 2012

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

Objectives. The purposes of this retrospective study were to compare various methods of apparent diffusion coefficient (ADC) measurement for head and neck lesions in half-Fourier single-shot turbo spin-echo (HASTE) diffusion-weighted imaging (DWI) and determine the threshold ADC value for predicting malignancy.Study Design. HASTE DW images of 46 lesions (10 cysts, 14 benign tumors, and 22 malignant tumors) were studied retrospectively. The ADC values were compared between 0-1000 method, 500-1000 method, and weighted linear regression (WLR) fit.Results. The highest overall accuracies of 83.3%, 86.1%, and 88.9% were obtained when ADC values of 1.24 × 10 -3 mm 2 /sec (0-1000 method), 0.98 × 10 -3 mm 2 /sec (500-1000 method), and 1.23 × 10 -3 mm 2 /sec (WLR fit), respectively, were used for the threshold.Conclusions. The present results indicate that ADC measurement with HASTE DWI is useful in predicting malignancy of head and neck lesions. 3

show abstract

Abdominal diffusion mapping with use of a whole-body echo-planar system.

Abstract: In vivo diffusion measurements of abdominal organs obtained with MR imaging may prove helpful in the identification and classification of abdominal disease.

Cited by 225 publications

References 0 publications

Diagnostic value of diffusion weighted MRI and ADC in differential diagnosis of cavernous hemangioma of the liver

Diagnostic value of diffusion weighted MRI and ADC in differential diagnosis of cavernous hemangioma of the liver

The value of diffusion weighted MR imaging and apparent diffusion coefficient quantification in the diagnosis of perforated and non-perforated appendicitis

Comparison of various methods for quantification of apparent diffusion coefficient of head and neck lesions with HASTE diffusion-weighted MR imaging

Contact Info

Product

Resources

About