Abdominal Aortic Calcification as a Marker of Relationship Between Atherosclerosis and Skeletal Fragility

Mazziotti, Gherardo; Tupputi, Umberto; Ferrante, Giuseppe; Guglielmi, Giuseppe

doi:10.1016/j.jocd.2020.05.001

Cited by 10 publications

(4 citation statements)

References 26 publications

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“…The overall AAC score, which can range from 0 to 24, is the cumulative score of these segments. For the purposes of this study, an AAC score above 6 was identified as a marker of severe AAC, aligning with the threshold commonly used in similar research [ 2 , 17 ].…”

Section: Methodsmentioning

confidence: 89%

“…Abdominal aortic calcification (AAC), characterized by the abnormal deposition of minerals like calcium and phosphate within the abdominal aorta wall, serves as an early indicator of atherosclerotic calcification and independently predicts cardiovascular events and overall mortality, often preceding coronary artery calcification [ 1 , 2 ]. Extensive studies have underscored intricate links of AAC to various medical conditions.…”

Section: Introductionmentioning

confidence: 99%

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Associations between dietary fatty acids intake and abdominal aortic calcification: a national population-based study

Xiao,

Quan

2024

Lipids Health Dis

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Background Abdominal aortic calcification (AAC) is a crucial indicator of cardiovascular health. This study aims investigates the associations between dietary fatty acid intake and AAC. Methods In this study, a cross-sectional assessment was performed on a group of 2,897 individuals aged 40 and above, utilizing data from the NHANES. The focus was on examining dietary consumption of various fatty acids, including Saturated (SFA), Monounsaturated (MUFA), Polyunsaturated (PUFA), as well as Omega-3 and Omega-6. The evaluation of AAC was done by applying the Kauppila AAC score to results obtained from dual-energy X-ray absorptiometry scans. For statistical analysis, weighted multivariate linear and logistic regression were employed, with adjustments for variables like gender, age, ethnicity, and overall health condition. Results Participants with higher intake of SFA and PUFA showed a positive association with AAC score, while higher levels of dietary Omega-3 and Omega-6 fatty acids was connected with a negative correlation. Subgroup analyses indicated consistent associations across different sexes and age groups. The study found that an increase in SFA and PUFA intake correlated with an increase in AAC score, whereas Omega-3 and Omega-6 intake correlated with a decrease. Conclusion This study underscores the importance of dietary fatty acid composition in the prevalence of AAC and its potential implications for dietary guidelines and cardiovascular disease prevention strategies.

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Section: Methodsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Associations between dietary fatty acids intake and abdominal aortic calcification: a national population-based study

Xiao,

Quan

2024

Lipids Health Dis

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“… [150] While not often done clinically, emerging research suggests that DXA can assess abdominal aortic calcification, which is a risk factor for ASCVD. [151] Increased abdominal aortic calcification is associated with increased risk for osteoporosis [152] .…”

Section: Imaging Studiesmentioning

confidence: 99%

Ten things to know about ten imaging studies: A preventive cardiology perspective (“ASPC top ten imaging”)

Bays

Khera

Blaha³

et al. 2021

American Journal of Preventive Cardiology

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Knowing the patient's current cardiovascular disease (CVD) status, as well as the patient's current and future CVD risk, helps the clinician make more informed patient-centered management recommendations towards the goal of preventing future CVD events. Imaging tests that can assist the clinician with the diagnosis and prognosis of CVD include imaging studies of the heart and vascular system, as well as imaging studies of other body organs applicable to CVD risk. The American Society for Preventive Cardiology (ASPC) has published “Ten Things to Know About Ten Cardiovascular Disease Risk Factors.” Similarly, this “ASPC Top Ten Imaging” summarizes ten things to know about ten imaging studies related to assessing CVD and CVD risk, listed in tabular form. The ten imaging studies herein include: (1) coronary artery calcium imaging (CAC), (2) coronary computed tomography angiography (CCTA), (3) cardiac ultrasound (echocardiography), (4) nuclear myocardial perfusion imaging (MPI), (5) cardiac magnetic resonance (CMR), (6) cardiac catheterization [with or without intravascular ultrasound (IVUS) or coronary optical coherence tomography (OCT)], (7) dual x-ray absorptiometry (DXA) body composition, (8) hepatic imaging [ultrasound of liver, vibration-controlled transient elastography (VCTE), CT, MRI proton density fat fraction (PDFF), magnetic resonance spectroscopy (MRS)], (9) peripheral artery / endothelial function imaging (e.g., carotid ultrasound, peripheral doppler imaging, ultrasound flow-mediated dilation, other tests of endothelial function and peripheral vascular imaging) and (10) images of other body organs applicable to preventive cardiology (brain, kidney, ovary). Many cardiologists perform cardiovascular-related imaging. Many non-cardiologists perform applicable non-cardiovascular imaging. Cardiologists and non-cardiologists alike may benefit from a working knowledge of imaging studies applicable to the diagnosis and prognosis of CVD and CVD risk – both important in preventive cardiology.

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“…In CKD patients and in the elderly, there is solid evidence that VC have prognostic value for future cardiovascular events and poorer prognosis [ 5 ]. The relationship between arterial calcification and bone physiology (known as the bone–vascular axis) [ 6 ] is supported by the association of VC with bone fractures [ 7 , 8 , 9 , 10 ], and by that of abdominal aorta calcifications (AAC) with vertebral fractures in particular [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Quantitative Computer-Assisted Score Can Improve Repeatability in the Estimate of Vascular Calcifications at the Abdominal Aorta

Fusaro

Schileo²,

Crimi³

et al. 2022

Nutrients

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In CKD and in the elderly, Vascular Calcifications (VC) are associated to cardiovascular events and bone fractures. VC scores at the abdominal aorta (AA) from lateral spine radiographs are widely applied (the 0–24 semiquantitative discrete visual score (SV) being the most used). We hypothesised that a novel continuum score based on quantitative computer-assisted tracking of calcifications (QC score) can improve the precision of the SV score. This study tested the repeatability and reproducibility of QC score and SV score. In forty-four patients with VC from an earlier study, five experts from four specialties evaluated the data twice using a dedicated software. Test–retest was performed on eight subjects. QC results were reported in a 0–24 scale to readily compare with SV. The QC score showed higher intra-operator repeatability: the 95% CI of Bland–Altman differences was almost halved in QC; intra-operator R2 improved from 0.67 for SV to 0.79 for QC. Inter-observer repeatability was higher for QC score in the first (Intraclass Correlation Coefficient 0.78 vs. 0.64), but not in the second evaluation (0.84 vs. 0.82), indicating a possible heavier learning artefact for SV. The Minimum Detectable Difference (MDD) was smaller for QC (2.98 vs. 4 for SV, in the 0–24 range). Both scores were insensitive to test–retest procedure. Notably, QC and SV scores were discordant: SV showed generally higher values, and an increasing trend of differences with VC severity. In summary, the new QC score improved the precision of lateral spine radiograph scores in estimating VC. We reported for the first time an estimate of MDD in VC assessment that was 25% lower for the new QC score with respect to the usual SV score. An ongoing study will determine whether this lower MDD may reduce follow-up times to check for VC progression.

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Abdominal Aortic Calcification as a Marker of Relationship Between Atherosclerosis and Skeletal Fragility

Cited by 10 publications

References 26 publications

Associations between dietary fatty acids intake and abdominal aortic calcification: a national population-based study

Associations between dietary fatty acids intake and abdominal aortic calcification: a national population-based study

Ten things to know about ten imaging studies: A preventive cardiology perspective (“ASPC top ten imaging”)

A Novel Quantitative Computer-Assisted Score Can Improve Repeatability in the Estimate of Vascular Calcifications at the Abdominal Aorta

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