Abdominal aortic calcification and renal resistive index in patients with chronic kidney disease: is there a connection?

Ștefan, Gabriel; Căpuşă, Cristina; Sica, Simona; Petrescu, L.; Nedelcu, Elena Dana; Andreiana, Iuliana; Mircescu, Gabriel

doi:10.1007/s40620-013-0021-4

Cited by 17 publications

(15 citation statements)

References 27 publications

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“…According to the authors, another pathophysiological explanation for the correlation between AAC and RRI is that systemic vascular calcification, especially renal artery calcification, impairs renal blood flow, thus increasing RRI. The present study demonstrated an association between AAC and RRI, thus offering more robust evidence for the association between vascular calcification and RRI [24]. The present study also established a correlation between age and increase in RRI.…”

Section: Discussionsupporting

confidence: 81%

Relationship between Aortic Arch Calcification, Detected by Chest X-Ray, and Renal Resistive Index in Patients with Hypertension

et al. 2018

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Objective: Aortic arch calcification (AAC) is a surrogate marker for arterial stiffness and hypertension-related vascular damage. Renal resistive index (RRI), a renal Doppler ultrasonography parameter, is used to assess renal hemodynamics. In this study, we aimed to evaluate the relationship between RRI and AAC in patients with hypertension. Methods: Patients with hypertension underwent a chest X-ray and re nal Doppler ultrasonography. They were divided into two groups according to RRI (group 1: RRI ≥0.70; group 2: RRI < 0.70). Two examiners, blinded to the findings of RRI, reviewed the AAC in these patients. The kappa value was detected to be 0.781 and a p value < 0.001 was considered significant. Results: The study included 289 hypertensive patients (mean age 63.87 ± 11.38 years). In 53.6% (n = 155) of the study subjects, RRI was observed to be ≥0.70. Patients with RRI ≥70 were older and had more prevalent AAC as well as left ventricular hypertrophy. A multiple linear regression analysis was carried out to test whether presence of AAC significantly predicted RRI. The results of the regression analysis indicated that presence of AAC significantly predicted RRI (β = 0.053; p < 0.001). Conclusions: A strong and independent relationship was found between AAC on chest X-ray and RRI in patients with hypertension.

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Section: Discussionsupporting

confidence: 81%

Relationship between Aortic Arch Calcification, Detected by Chest X-Ray, and Renal Resistive Index in Patients with Hypertension

et al. 2018

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“…In a recent study of 77 CKD subjects, abdominal aortic calcifications were directly related to RRI (r Z 0.35 p < 0.001) and cIMT (r Z 0.27 p Z 0.01) [26]. Furthermore, several studies found correlations between arterial wall calcifications and systemic atherosclerotic damage, especially in CKD patients [27].…”

Section: Discussionmentioning

confidence: 94%

Renal haemodynamics and severity of carotid atherosclerosis in hypertensive patients with and without impaired renal function

Geraci

Mulè

Mogavero

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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“…Vascular calcifications of the large arteries, like abdominal aorta (assessed by the lumbar aortic calcification score-ACS) is not only a predictor of the cardiovascular morbidity and mortality, but it could also provide an indirect estimation of the intrarenal vascular status, as we found in a cross-sectional study that enrolled 77 stages 2-5 non-dialysis CKD patients, older than 50 years, and with known atherosclerotic disease. This study described increased aortic calcification as eGFR declines and found that higher lumbar aortic calcification score was independently associated with lower ankle-brachial index and higher intima-media thickness, suggesting a relationship of abdominal calcifications with the extension of atherosclerosis in other territories [85]. In addition, the novel finding of the study was the ability of an aortic calcification score >5 to predict with 65% sensitivity and 68% specificity a pathologic (<0.7) renal resistive index (marker of intrarenal atherosclerotic lesions on Doppler ultrasound) [85].…”

Section: Atherosclerotic Cardiovascular Diseasementioning

confidence: 82%

“…This study described increased aortic calcification as eGFR declines and found that higher lumbar aortic calcification score was independently associated with lower ankle-brachial index and higher intima-media thickness, suggesting a relationship of abdominal calcifications with the extension of atherosclerosis in other territories [85]. In addition, the novel finding of the study was the ability of an aortic calcification score >5 to predict with 65% sensitivity and 68% specificity a pathologic (<0.7) renal resistive index (marker of intrarenal atherosclerotic lesions on Doppler ultrasound) [85].…”

Section: Atherosclerotic Cardiovascular Diseasementioning

confidence: 82%

Mechanisms and Clinical Implications of Vascular Calcifications in Chronic Kidney Disease

Căpuşă¹,

Popescu²

2018

Chronic Kidney Disease - From Pathophysiology to Clinical Improvements

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Chronic kidney disease (CKD), a major public health problem that affects up to 10-13% of the general population worldwide, imposes considerable socioeconomic burden due to both the need for renal replacement therapy and, even more important, the negative influence on the overall patients' health status. Cardiovascular (CV) diseases are the main cause of death in CKD patients and are triggered not only by the traditional CV risk factors but also by specific, uremia-related, factors. Among these, calcium-phosphate and bone metabolism disorders play a central role. Abnormalities of mineral metabolism occur early, evolve silently as the kidney function deteriorates, and are associated with CV morbidity and mortality, mainly by the development of valvular and vascular calcifications. This chapter aims to summarize the recent knowledge on the types and mechanisms of arterial calcifications, as well as their clinical implications, in the setting of CKD. The issue is significant for both nephrologists and cardiologists and could be an example of the requirement for interdisciplinary collaboration in the medical practice.

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Abdominal aortic calcification and renal resistive index in patients with chronic kidney disease: is there a connection?

Abstract: As Kauppila score correlates with RRI in non-dialysis CKD patients, it could be a fast, convenient and relatively inexpensive tool for estimating RRI, and consequently the intrarenal vascular status, but further research is warranted.

Cited by 17 publications

References 27 publications

Relationship between Aortic Arch Calcification, Detected by Chest X-Ray, and Renal Resistive Index in Patients with Hypertension

Relationship between Aortic Arch Calcification, Detected by Chest X-Ray, and Renal Resistive Index in Patients with Hypertension

Renal haemodynamics and severity of carotid atherosclerosis in hypertensive patients with and without impaired renal function

Mechanisms and Clinical Implications of Vascular Calcifications in Chronic Kidney Disease

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