Abdominal adipose tissue compartments vary with ethnicity in Asian neonates: Growing Up in Singapore Toward Healthy Outcomes birth cohort study

Tint, Mya Thway; Fortier, Marielle V.; Godfrey, Keith M.; Shuter, Borys; Kapur, Jeevesh; Rajadurai, Victor Samuel; Agarwal, Pratibha; Amutha, C.; Niduvaje, Krishnamoorthy; Chan, Yiong‐Huak; Aris, Izzuddin M.; Soh, Shu‐E; Yap, Fabian; Saw, Seang‐Mei; Kramer, Michael S.; Gluckman, Peter D.; Chong, Yap Seng; Lee, Yung Seng

doi:10.3945/ajcn.115.108738

Cited by 28 publications

(40 citation statements)

References 42 publications

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“…South Asians accumulate higher body fat than Caucasians, even at low BMI, and also show a stronger association between abdominal adiposity and hyperinsulinemia . Ethnic differences in abdominal fat partitioning have also been reported in Asian neonates within 3 weeks of birth . In our current study, Indian children had the lowest levels of VAT among lean children yet showed the strongest tendency to accumulate VAT with increasing BMI.…”

Section: Discussionsupporting

confidence: 74%

“…These ethnic differences have been shown to be present even at birth (20,21). In the GUSTO cohort, we previously reported that Indian and Malay neonates had a larger DSAT volume than Chinese neonates, with no differences in SSAT or VAT volumes (21). At 4.5 years, we continue to find that abdominal fat partitions differently among the three ethnic groups for all the subcutaneous fat depots (total SAT, DSAT, and SSAT) but not for VAT.…”

Section: Discussionsupporting

confidence: 54%

“…Indian adults have been reported to accumulate more visceral fat even at low BMI values compared with other ethnic groups (35). These ethnic differences have been shown to be present even at birth (20,21). In the GUSTO cohort, we previously reported that Indian and Malay neonates had a larger DSAT volume than Chinese neonates, with no differences in SSAT or VAT volumes (21).…”

Section: Discussionmentioning

confidence: 88%

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Association Between Early Life Weight Gain and Abdominal Fat Partitioning at 4.5 Years is Sex, Ethnicity, and Age Dependent

Sadananthan

Tint

Michael

et al. 2019

Obesity

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Objective To investigate the independent associations between age-specific annual weight gain from birth to age 4 years and fat deposition in metabolically distinct compartments at age 4.5 years in a South Asian longitudinal birth cohort. Methods Volumetric abdominal MRI with comprehensive segmentation of deep (DSAT) and superficial subcutaneous (SSAT), and visceral adipose tissues (VAT) was performed in 316 children (150 boys, and 166 girls in three ethnic groups: 158 Chinese, 94 Malay, and 64 Indian) aged 4.5 years. Associations between fat volumes and annual relative weight gain conditional on past growth were assessed overall and stratified by sex and ethnicity. Results Conditional relative weight gain had stronger associations with greater SAT and VAT at age 4.5 years in girls than boys, and in Indians compared with Malay and Chinese. Overall, the magnitude of association was the largest during 2-3 years for SAT, and 1-2 years for VAT. Despite similar body weight, Indian children, and girls had the highest DSAT and SSAT volumes at age 4.5 years (all p-interaction<0.05). No significant sex or ethnic differences were observed in VAT. With increasing BMI, Indian children had the highest tendency to accumulate VAT, and girls accumulated more fat than boys in all depots (all p-interaction<0.001). Conclusions Indian ethnicity and female sex predisposed children to accumulate more fat in the visceral adipose depot with increasing conditional relative weight gain in the second year of life. Thus, 1-2 years age may be a critical window for interventions to reduce visceral fat accumulation.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 54%

Section: Discussionmentioning

confidence: 88%

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Association Between Early Life Weight Gain and Abdominal Fat Partitioning at 4.5 Years is Sex, Ethnicity, and Age Dependent

Sadananthan

Tint

Michael

et al. 2019

Obesity

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“…Women who provided 24-h recalls reported to be reflective of their typical diets and who had information on their offspring's birth anthropometric measurements (n = 1051), total body composition (n = 313), and abdominal adiposity (n = 316) were included in the analysis (Supplemental Figure 1). There were no significant differences in characteristics (birth weight, gestational age, parity, and prepregnancy BMI) between neonates who had undergone MRI and those who did not undergo MRI (42) or Pea Pod measurements (Supplemental Table 1). To evaluate whether possible selection bias may have affected the results, we conducted sensitivity analysis for infant birth anthropometry outcomes by limiting the analysis to a subset of participants with MRI and Pea Pod measurements (n = 166).…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Neonatal abdominal adiposity was assessed by using MRI (GE Signa HDxt 1.5 Tesla MR scanner) approximately within the first 2 wk of life (42). Subsets of 313 infants and 316 infants in this study had Pea Pod and MRI data, respectively.…”

Section: Infant Birth Outcomesmentioning

confidence: 99%

Adherence to a healthy eating index for pregnant women is associated with lower neonatal adiposity in a multiethnic Asian cohort: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) Study

Chia

Tint

Han

et al. 2018

The American Journal of Clinical Nutrition

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Background: Evidence linking maternal diet quality during pregnancy with infant birth outcomes is limited in Asia. Objective: We investigated the association of maternal diet quality with the risk of preterm birth, offspring birth size, and adiposity in a multiethnic Asian birth cohort. Design: Dietary intakes of 1051 pregnant women were ascertained at 26-28 wk of gestation with the use of 24-h recalls and 3-d food diaries, from which diet quality (score range: 0-100) was measured by the Healthy Eating Index for pregnant women in Singapore (HEI-SGP). Gestational age was established by first-trimester ultrasound dating scan. Neonatal weight and length were measured at birth. Body composition was assessed by air displacement plethysmography in a subset of infants (n = 313) within 72 h after birth, and abdominal adiposity was assessed by MRI (n = 316) within the first 2 wk of life. Associations were assessed by multivariable linear regression for continuous outcomes and logistic regression for preterm birth. Results: The mean ± SD maternal HEI-SGP score was 52.1 ± 13.6. Maternal diet quality during pregnancy was not associated with preterm birth or birth weight. Greater adherence to the HEI-SGP (per 10-point increment in HEI-SGP score) was associated with longer birth length [β (95% CI): 0.14 (0.03, 0. Conclusions:Higher maternal diet quality during pregnancy was associated with longer birth length and lower neonatal adiposity but not with birth weight and preterm birth. These findings warrant further investigation in independent studies. This trial was registered at clinicaltrials.gov as NCT01174875.Am J Clin Nutr 2018;107:71-79.

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Early-Life Nutrition, Epigenetics and Prevention of Obesity

El‐Heis

Lillycrop

Burdge

et al. 2018

Epigenetics in Human Disease

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Abdominal adipose tissue compartments vary with ethnicity in Asian neonates: Growing Up in Singapore Toward Healthy Outcomes birth cohort study

Cited by 28 publications

References 42 publications

Association Between Early Life Weight Gain and Abdominal Fat Partitioning at 4.5 Years is Sex, Ethnicity, and Age Dependent

Association Between Early Life Weight Gain and Abdominal Fat Partitioning at 4.5 Years is Sex, Ethnicity, and Age Dependent

Adherence to a healthy eating index for pregnant women is associated with lower neonatal adiposity in a multiethnic Asian cohort: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) Study

Early-Life Nutrition, Epigenetics and Prevention of Obesity

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