ABCL-312: Survival Outcomes of Primary Intraocular Lymphoma

Mohamed, Shehab; Khan, Maliha; Parrish, Julia E.; Barrios, Patricia Chevez; Dabaja, B.; Fowler, Nathan; Gombos, Dan S.; Liu, Feng; Iyer, Saminathan

doi:10.1016/s2152-2650(21)01886-3

Cited by 1 publication

(2 citation statements)

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“…Progression to bilateral or CNS involvement is the natural course of PCNSL and occurs in 75% to 87% of patients by 4 years. 6,7 PCNSL or bilateral PCNSL-O is often found during workup; however, unilateral PCNSL-O makes up a small but increasing fraction of all PCNSL and PCNSL-O cases. 1,9,11 Although one would expect unilateral disease to be less severe, a recent French nationwide database showed that unilateral PCNSL-O had a worse prognosis (51-month median survival) than bilateral disease (75-month median survival).…”

Section: Discussionmentioning

confidence: 99%

“…3,4 PCNSL-O historically presented bilaterally in 64% to 83% of cases; however, recent reports indicate bilateral presentation in only 25% of cases. 6,7 The increasing incidence of unilateral PCNSL-O presentation could be related to earlier diagnosis. However, the overall survival for unilateral PCNSL-O is 24 months shorter than for bilateral PCNSL-O, and the recommendation for limited local treatment of unilateral PCNSL-O may be related to the worse systemic outcomes in unilateral disease.…”

Section: Introductionmentioning

confidence: 99%

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Primary Autologous Stem Cell Transplantation for Unilateral Primary Central Nervous System Lymphoma–Ophthalmic Variant (Primary Vitreoretinal Lymphoma)

Lee

Vos

McCannel

2023

Journal of VitreoRetinal Diseases

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Purpose: To describe the long-term outcomes of 2 cases of primary autologous stem cell transplantation (ASCT) for the treatment of primary central nervous system lymphoma–ophthalmic variant (PCNSL-O) or primary vitreoretinal lymphoma (PVRL). Methods: Two cases and their findings were analyzed. A review of the histopathology, systemic treatment, and multimodal ocular imaging was performed. Results: A 52-year-old woman and 56-year-old woman were referred for vitritis and retinal lesions suspicious for PCNSL-O. The initial vitreous biopsies were inconclusive. Both patients had subsequent chorioretinal biopsies that confirmed the diagnosis of diffuse large B-cell lymphoma. No systemic or central nervous system involvement was found on systemic workup. Both patients received intravitreal and systemic chemotherapy followed by ASCT, and both remained in complete remission 7 and 8 years later. Conclusions: These cases show the long-term survival of patients diagnosed with PVRL when primary ASCT, the primary treatment for PCNSL, is performed.

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