Purpose: To describe the long-term outcomes of 2 cases of primary autologous stem cell transplantation (ASCT) for the treatment of primary central nervous system lymphoma–ophthalmic variant (PCNSL-O) or primary vitreoretinal lymphoma (PVRL). Methods: Two cases and their findings were analyzed. A review of the histopathology, systemic treatment, and multimodal ocular imaging was performed. Results: A 52-year-old woman and 56-year-old woman were referred for vitritis and retinal lesions suspicious for PCNSL-O. The initial vitreous biopsies were inconclusive. Both patients had subsequent chorioretinal biopsies that confirmed the diagnosis of diffuse large B-cell lymphoma. No systemic or central nervous system involvement was found on systemic workup. Both patients received intravitreal and systemic chemotherapy followed by ASCT, and both remained in complete remission 7 and 8 years later. Conclusions: These cases show the long-term survival of patients diagnosed with PVRL when primary ASCT, the primary treatment for PCNSL, is performed.
Context Gestational diabetes (GDM) imposes long-term adverse health effects on the mother and fetus. The role of magnetic resonance imaging (MRI) during early gestation in GDM has not been well-studied. Objective To investigate the role of quantitative MRI measurements of placental volume and perfusion, with distribution of maternal adiposity, during early-gestation in GDM. Design ∼200 pregnant women recruited in the first trimester were followed temporally through pregnancy until parturition. Setting Outpatient antenatal obstetrics clinics. Interventions Two placental MRI scans were prospectively performed at 14-16 weeks and 19-24 weeks gestational age (GA). Placental volume and blood flow (PBF) were calculated from placental regions of interest; maternal adiposity distribution was assessed by subcutaneous fat area ratio (SFAR) and visceral fat area ratio (VFAR). Statistical comparisons were performed using the two-tailed t-test. Predictive logistic regression modeling was evaluated by area under the curves (AUC). Results Of a total 186 subjects, 21 subjects (11.3%) developed GDM. VFAR was higher in GDM versus the control group, at both time points (p < 0.001 each). Placental volume was greater in GDM versus the control group at 19-24 weeks GA (p = 0.01). Combining VFAR, placental volume and perfusion, improved the AUCs to 0.83 at 14-16 weeks (PPV = 0.77, NPV = 0.83), and 0.81 at 19-24 weeks GA (PPV = 0.73, NPV = 0.86). Conclusion A combination of MRI-based placental volume, perfusion and visceral adiposity during early pregnancy demonstrates significant changes in GDM and provides a proof of concept for predicting the subsequent development of GDM.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.