ABCA1 and Biogenesis of HDL

Yokoyama, Shinji

doi:10.5551/jat.13.1

Cited by 64 publications

(42 citation statements)

References 134 publications

(117 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…ABCA1 plays a role in the biogenesis of anti-atherogenic highdensity lipoproteins (HDL) in the intestinal lining [45,46,47]. Using enterocyte specific ABCA1 knock-out mice, Brunham et al [48] showed that in mice approximately 30% of the steady state plasma HDL pool was due to intestinal ABCA1 activity.…”

Section: Sterol Transportersmentioning

confidence: 99%

Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract

Masson¹,

Mensink²,

Namiot³

et al. 2010

Atherosclerosis Supplements

View full text Add to dashboard Cite

Section: Sterol Transportersmentioning

confidence: 99%

Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract

Masson¹,

Mensink²,

Namiot³

et al. 2010

Atherosclerosis Supplements

View full text Add to dashboard Cite

“…Adenosine triphosphate (ATP)-binding cassette transporter (ABC) A1 has been identified as a pivotal gene in the regulation of both plasma HDL cholesterol levels and cellular cholesterol homeostasis, which is a key molecule in the first step of RCT. ABCA1 gene deficiency causes decreases in HDL cholesterol and the capacity of skin fibroblasts and monocyte-derived macrophages to release cholesterol in the extracellular presence of apolipoprotein (apo)A-or apoE 1,3) . ABCG1 is another member of the ABC trans-…”

mentioning

confidence: 99%

Genotypic Effect of ABCG1 Gene Promoter -257T>G Polymorphism on Coronary Artery Disease Severity in Japanese Men

Furuyama

Uehara

Zhang

et al. 2009

JAT

View full text Add to dashboard Cite

Aim: ATP-binding cassette transporter G1 (ABCG1) is a cholesterol transporter that plays a role in cholesterol efflux in the presence of high-density lipoprotein (HDL). Moreover, HDL-mediated cholesterol efflux is increased in cultured ABCG1 overexpressed cells; however, the physiological roles of ABCG1 and its contribution to atherosclerosis in humans remain unclear. Methods: The effect of ABCG1 257T G mutation on transcription activity was determined by a reporter assay. One hundred nine Japanese men with coronary artery disease (CAD) were analyzed. ABCG1 257T G polymorphism was assessed by mutation-selective PCR methods to identify T/T, T/G, and G/G genotypes. Results:The reporter assay showed that ABCG1 transcription activity was significantly lower (p 0.01) in the G allele of 257T G polymorphism compared with that in the T allele. Clinically, there were no significant differences in serum triglyceride and total, LDL, and HDL cholesterol levels, or other risk factors. Logistic regression analysis revealed significant additive and dominant effects on the frequency of patients with multi-vessel disease compared with single-vessel disease

show abstract

“…port system, in which excess cholesterol is extracted from atheromatous plaques, is considered important in stabilizing plaques and preventing plaque rupture 2,3) . A recent study reported that in addition to the reverse cholesterol system, HDL infusion could stabilize atheromatous plaque through its anti-inflammatory properties 4) .…”

mentioning

confidence: 99%

HDL/Apolipoprotein A-I Binds to Macrophage-Derived Progranulin and Suppresses its Conversion into Proinflammatory Granulins

Okura

Yamashita

Ohama

et al. 2010

JAT

View full text Add to dashboard Cite

Aim: HDL has anti-inflammatory effects on macrophages, although the mechanism of action remains unclear. We hypothesized that HDL suppresses the conversion of macrophage-secreted factors into proinflammatory factors via binding, and tried to identify the factor that could form a complex with HDL and/or apolipoprotein (apo) A-I. Methods and Results: In conditioned media obtained from human monocyte-derived macrophages, we found an apo A-I binding protein and identified the protein as progranulin/proepithelin/ acrogranin/PCDGF. Co-immunoprecipitation analysis showing that progranulin binds and forms a complex with apo A-I and the presence of progranulin in the HDL fraction in the sera indicated that progranilin is a novel apolipoprotein. Conditioned media of HEK293 cells transfected with progranulin augmented the expression of TNF-alpha and IL-1-beta on macrophages, but these effects of progranulin were inhibited by co-incubation with HDL or apo A-I. Anti-progranulin antibodies also reduced the expression of TNF-alpha and IL-1-beta on macrophages. Granulins as conversion products derived from progranilin increased TNF-alpha and IL-1-beta expression and the effects were not suppressed by HDL. Conclusions: Our results suggest that the anti-inflammatory effects of HDL on macrophages might be due to suppression of the conversion of progranulin into proinflammatory granulins by forming a complex.

show abstract

ABCA1 and Biogenesis of HDL

Cited by 64 publications

References 134 publications

Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract

Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract

Genotypic Effect of ABCG1 Gene Promoter -257T>G Polymorphism on Coronary Artery Disease Severity in Japanese Men

HDL/Apolipoprotein A-I Binds to Macrophage-Derived Progranulin and Suppresses its Conversion into Proinflammatory Granulins

Contact Info

Product

Resources

About