Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract

Masson, C.; Mensink, R.P.; Namiot, Andrzej; Kisielewski, W; Namiot, Z; Füllekrug, Joachim; Ehehalt, Robert; Glatz, Jan F. C.; Pelsers, Maurice M.A.L.

doi:10.1016/j.atherosclerosissup.2010.04.031

Cited by 11 publications

(13 citation statements)

References 61 publications

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“…In this way, transmembrane delivery of LCFAs to intracellular sites is both accelerated and vectorial. Supporting this model is the observation that CD36 can bind to both FABPpm and FABPc (Glatz et al, 2010;Masson et al, 2010;Spitsberg et al, 1995). Further support is found in transfection studies, in which transfection of CD36 alone is not sufficient to increase fatty acid uptake across cell membranes.…”

Section: Role Of Cd36 In Fatty Acid Transportmentioning

confidence: 60%

Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet

Lynes

Widmaier

2011

Life Sciences

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Section: Role Of Cd36 In Fatty Acid Transportmentioning

confidence: 60%

Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet

Lynes

Widmaier

2011

Life Sciences

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“…117 Ingested vitamin D is presumed to follow the same fate as dietary lipids, although new data reveal that digestive and absorptive processes may be more complex than previously recognized as large interindividual variation in postprandial responses to vitamin D has been observed. 118,119 During digestion, vitamin D is transferred to the mixed micelles generated by the lipolysis of dietary fat. 120 Upon uptake through the brush border, vitamin D becomes incorporated into chylomicrons along with the other products of fat digestion, and approximately 80% is absorbed into the lymphatic system.…”

Section: Treatment Strategy For Vitamin D Deficiencymentioning

confidence: 99%

Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations

Peterson¹

2015

NDS

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Vitamin D deficiency and childhood obesity have been classified as epidemics throughout the world, and both share some common risk factors including poor diet and inactivity. Observational and clinical studies show that vitamin D status and fat mass are inversely correlated. It is not clear whether vitamin D deficiency contributes to, or is a consequence of obesity, or whether there are regulatory interactions between excess adiposity and vitamin D activity. The effects of this deficiency in childhood obesity appear to have negative influences on overall health, including insulin resistance, inflammation, and impeded bone mineralization, as well as increased future risk of type 2 diabetes, cardiovascular disease, and osteoporosis. The rather ubiquitous distribution of the vitamin D receptor and the 25-hydroxyvitamin D 1α-hydroxylase throughout the body, including evidence for a role of vitamin D in adipogenesis and adipocyte metabolism, may in part explain these widespread effects. Most of the findings to date suggest that the vitamin D needs of obese children are greater than the nonobese. Although ultraviolet B-induced skin synthesis is a main source of vitamin D, its use is neither feasible nor prudent due to limited sun availability for many and concerns for skin cancer. Likewise, obtaining adequate vitamin D from natural food sources alone is generally not achievable, and even in countries that allow fortification, vitamin D intakes are low. Therefore, in obese children, vitamin D supplementation is warranted. Weight loss interventions using energy restriction and physical activity may also improve the poor vitamin D status associated with obesity. More research is needed to define optimal vitamin D status in this vulnerable population, including investigations to determine the efficacy of vitamin D supplementation in attenuating the conditions associated with childhood obesity, and to further elucidate the mechanisms by which vitamin D exerts its effects on health.

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“…The intestinal distribution of transporters involved in cholesterol absorption – transporters also involved in vitamin E absorption – was recently measured in intestinal samples from 11 subjects. Results showed a bell‐shaped distribution, with the highest concentrations in the ileum being those of NPC1L1 and ABCA1 . Another significant variable that can modulate vitamin E absorption is the repartition of vitamin E transporters between the basolateral and apical membranes of the intestinal cell.…”

Section: Metabolization Of Vitamin E In the Upper Gastrointestinal Tractmentioning

confidence: 99%

“…Results showed a bell-shaped distribu-tion, with the highest concentrations in the ileum being those of NPC1L1 and ABCA1. 34 Another significant variable that can modulate vitamin E absorption is the repartition of vitamin E transporters between the basolateral and apical membranes of the intestinal cell. This repartition is different along the gut: SR-BI, which is involved in vitamin E absorption, is present mainly on the apical membrane of the proximal intestine, but mainly on the basolateral surface of the distal intestine.…”

Section: Metabolization Of Vitamin E In the Upper Gastrointestinal Tractmentioning

confidence: 99%

Bioavailability of vitamin E in humans: an update

2013

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Vitamin E is essential for human health and may play a role in the prevention of some degenerative diseases. Its bioavailability, however, is wide ranging and is affected by numerous factors. Recent findings showing that the intestinal absorption of vitamin E involves proteins have raised new relevant questions about factors that can affect bioavailability. It is, therefore, opportune to present a current overview of this topic. This review begins by exploring what is known, as well as what is unknown, about the metabolization of vitamin E in the human upper gastrointestinal tract and then presents a methodical evaluation of factors assumed to affect vitamin E bioavailability. Three main conclusions can be drawn. First, the proteins ABCA1, NPC1L1, and SR-BI are implicated in the absorption of vitamin E. Second, the efficiency of vitamin E absorption is widely variable, though not accurately known (i.e., between 10% and 79%), and is affected by several dietary factors (e.g., food matrix, fat, and fat-soluble micronutrients). Finally, numerous unanswered questions remain about the metabolization of vitamin E in the intestinal lumen and about the factors affecting the efficiency of vitamin E absorption.

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Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract

Cited by 11 publications

References 61 publications

Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet

Involvement of CD36 and intestinal alkaline phosphatases in fatty acid transport in enterocytes, and the response to a high-fat diet

Vitamin D deficiency and childhood obesity: interactions, implications, and recommendations

Bioavailability of vitamin E in humans: an update

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