ABC Transporters in Human Placenta and Their Role in Maternal-Fetal Cholesterol Transfer: ABCA1 Candidate Target

Bhattacharjee, J.; Ietta, Francesca; Romagnoli, Roberta; Bechi, Nicoletta; Caniggia, Isabella; Paulesu, Luana

doi:10.5772/34487

Cited by 4 publications

(7 citation statements)

References 110 publications

(119 reference statements)

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“…Its role involves transfer of nutrients and respiratory gases from the mother to the fetus, removal of metabolic waste products from the fetus to the mother, and synthesis of steroids, hormones and peptides that are necessary for the successful progression of pregnancy (Syme et al, 2004;Behravan & Piquette-Miller, 2007;Aye & Keelan, 2013). Similar to the BBB, the placental barrier has a role as a selective filter for potential harmful substances circulating in the maternal blood (Syme et al, 2004;Bhattacharjee et al, 2012). The mechanisms by which various substances are transported into the fetal CNS across protective barriers and their developmental timeline is crucial in understanding the potential impact of various environmental agents on early development and identifying the developmental periods of vulnerability, respectively.…”

Section: Protective Barriersmentioning

confidence: 99%

“…The ABC A family of transporters has a key role in sterol homeostasis, cholesterol transport, plasma membrane fluidity and lipid metabolism in the brain (Hartz & Bauer, 2011;Tarling et al, 2013). ABCA1 is expressed in the BBB and placental barrier, and has a key role in the ejection of plasma membrane phospholipids and cholesterol (Bhattacharjee et al, 2012;Aye & Keelan, 2013; Fig. 1).…”

Section: Abc a Proteinsmentioning

confidence: 99%

“…1). Substrates of ABCA1 include cholesterol, phospholipids and vitamin E (Bhattacharjee et al, 2012;Tarling et al, 2013). To date, the evidence shows that ABCA1 is expressed as early as E13 in the BBB, astrocytes, microglia and neurons in the developing mouse brain (Koldamova et al, 2003;Tachikawa et al, 2005;Kim et al, 2006;Fujiyoshi et al, 2007; Fig.…”

Section: Abc a Proteinsmentioning

confidence: 99%

“…P-gp has a broad substrate specificity, which includes: lipid compounds, various drugs, steroids and cytokines (Kusuhara & Sugiyama, 2005;Loscher & Potschka, 2005;Girardin, 2006;Vahakangas & Myllynen, 2009;Klaassen & Aleksunes, 2010). P-gp is localized in the luminal and abluminal membrane of cerebral endothelial cells, microglia and pericytes (Lee et al, 2001;Berezowski et al, 2004;Kusuhara & Sugiyama, 2005;Dallas et al, 2006;Vahakangas & Myllynen, 2009;Bhattacharjee et al, 2012; Fig. 1).…”

Section: Abc B Proteins/p-glycoprotein (P-gp)mentioning

confidence: 99%

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Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders

Wong

Wais

Crawford

2015

Eur J of Neuroscience

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The prevalence of autism spectrum disorders (ASDs) has been on the rise over recent years. The presence of diverse subsets of candidate genes in each individual with an ASD and the vast variability of phenotypical differences suggest that the interference of an exogenous environmental component may greatly contribute to the development of ASDs. The lipid mediator prostaglandin E2 (PGE2 ) is released from phospholipids of cell membranes, and is important in brain development and function; PGE2 is involved in differentiation, synaptic plasticity and calcium regulation. The previous review already described extrinsic factors, including deficient dietary supplementation, and exposure to oxidative stress, infections and inflammation that can disrupt signaling of the PGE2 pathway and contribute to ASDs. In this review, the structure and establishment of two key protective barriers for the brain during early development are described: the blood-brain barrier; and the placental barrier. Then, the first comprehensive summary of other environmental factors, such as exposure to chemicals in air pollution, pesticides and consumer products, which can also disturb PGE2 signaling and increase the risk for developing ASDs is provided. Also, how these exogenous agents are capable of crossing the protective barriers of the brain during critical developmental periods when barrier components are still being formed is described. This review underlines the importance of avoiding or limiting exposure to these factors during vulnerable periods in development.

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Section: Protective Barriersmentioning

confidence: 99%

Section: Abc a Proteinsmentioning

confidence: 99%

Section: Abc a Proteinsmentioning

confidence: 99%

Section: Abc B Proteins/p-glycoprotein (P-gp)mentioning

confidence: 99%

See 2 more Smart Citations

Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders

Wong

Wais

Crawford

2015

Eur J of Neuroscience

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“…ABC proteins are expressed in healthy tissues of the lung, breast, intestine, liver, ovary, testis, kidney, brain and heart. ABC transporters also play a significant role in placental cells mediating normal fetal development and participate in distribution of nutrients and exchange of metabolites across the placenta [2]. In adults, the activity of these molecules was reported to be associated with an individual's circadian rhythm [3].…”

Section: Importance Of Abc Transporters In Different Tissuesmentioning

confidence: 99%

Importance of ABC transporters in different tissues

Vetrivel

Subramanian

2014

Drug Metabolism and Drug Interactions

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Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas

Sai

Liu

et al. 2022

Arthritis Res Ther

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Background Systemic lupus erythematosus (SLE) can cause placental dysfunctions, which may result in pregnancy complications. Long noncoding RNAs (lncRNAs) are actively involved in the regulation of immune responses during pregnancy. The present study aimed to determine the lncRNA expression profiles in placentas from women with SLE to gain new insights into the underlying molecular mechanisms in SLE pregnancies. Methods RNA sequencing (RNA-seq) analysis was performed to identify SLE-dysregulated lncRNAs and mRNAs in placentas from women with SLE and normal full-term (NT) pregnancies. Bioinformatics analysis was conducted to predict the biological functions of these SLE-dysregulated lncRNAs and mRNAs. Results RNA-seq analysis identified 52 dysregulated lncRNAs in SLE placentas, including 37 that were upregulated and 15 downregulated. Additional 130 SLE-dysregulated mRNAs were discovered, including 122 upregulated and 8 downregulated. Bioinformatics analysis revealed that SLE-dysregulated genes were associated with biological functions and gene networks, such as regulation of type I interferon-mediated signaling pathway, response to hypoxia, regulation of MAPK (mitogen-activated protein kinase) cascade, response to steroid hormone, complement and coagulation cascades, and Th1 and Th2 cell differentiation. Conclusions This is the first report of the lncRNA profiles in placentas from SLE pregnancies. These results suggest that the aberrant expression and the potential regulatory function of lncRNAs in placentas may play comprehensive roles in the pathogenesis of SLE pregnancies. SLE-dysregulated lncRNAs may potentially serve as biomarkers for SLE.

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ABC Transporters in Human Placenta and Their Role in Maternal-Fetal Cholesterol Transfer: ABCA1 Candidate Target

Cited by 4 publications

References 110 publications

Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders

Prenatal exposure to common environmental factors affects brain lipids and increases risk of developing autism spectrum disorders

Importance of ABC transporters in different tissues

Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas

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