Abberant Lymphocytes Rate after Gamma-Irradiationn as a Biomarker of Breast Cancer

Abstract

Predisposition to cancer and ... [8] Chromosomal radiosensitivity: A study of the chromosomal G(2) assay in human blood lymphocytes indicating significant ... [9] The G2 ... [10] Is chromosome radiosensitivity and apoptotic response to irradiation correlated with cancer ... [11] Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer ... [12] Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic ... [13] Increased chromosomal radiosensitivity in breast cancer patients: A comparison of two ... [14] Relationship between in vitro chromosomal radiosensitivity of peripheral ... [15] Heritability of cellular radiosensitivity ... [16] Nucleotide Excision Repair Syndromes ... [17] Xeroderma pigmentosum: A human disease in ... [18] Cytogenetic status of ataxia ... [19] Enhanced chromatid damage ... [20] Radiationinduced micronucleus induction in lymphocytes identifies a ... [21] Genotoxic effects of radiotherapy and ... [22] Chromosomes, cancer and ... [23] Chromosomal radiosensitivity in G2-phase lymphocytes identifies breast cancer ... [24] Increased G2 chromosomal radiosensitivity in cancer patients ... [25] Deficient DNA repair capacity, apredisposing ... [26] Genetic predisposition in ... [27] Evaluating the effects of genetic variants ... [28] G2 checkpoint control and G2 chromosomal radiosensitivity ... [29] DNA repair capacity as a possible biomarker ... [30] Chromosomal radiosensitivity as a ... [31] Validation of the cell cycle G(2) ... [32] Chromosomal radiosensitivity in ... [33] G2-phase chromosomal radiosensitivity ... [34] Spontaneous and radiation-induced ... [35] Chromosomal radiosensitivity in head and neck cancer patients: Evidence for ... Aims The use of non-invasive laboratory tests based on detection of biomarkers in the blood samples is a good strategy for early diagnosis of breast cancer. The lymphocyte radiosensitivity assessment can be a valuable method to diagnose breast cancer. The objective of this study was to investigate the radiosensitivity indices in sporadic breast cancer among Iranian women and to evaluate the potential of those indices for clinical use in early diagnosis of breast cancer and assessing its susceptibility. Materials & Methods The present study is a case-control that was conducted on 32 patients with sporadic breast cancer (patient group) and 30 healthy individuals (control group). The obtained blood samples of both groups were exposed to gamma-irradiation (0.4 Gy) and the level of chromosome breakage was determined based on the G2 chromosome breakage assay protocol. In the metaphase lymphocytes, the percentage of the abnormal cells was calculated as the radiosensitivity index for comparing the two groups. Data were analyzed by SPSS 19 software using student t-test, paired t-test, chi-square and Fisher exact test. Findings There was a significant difference in the percentage of the index of the abnormal cells after irradiation between two groups (p=0.001). The area under the curve (AUC) of the pe...