AB0913 Influence of Gender on Disease Activity, Body Composition and Bone Mineral Density in Patients with Juvenile Idiopathic Arthritis

Abstract

Objectives To evaluate the association between gender, disease activity, body composition and bone mineral density in patients with juvenile idiopathic arthritis. Methods Our study was a cross-sectional study including Moroccan patients with juvenile idiopathic arthritis according to the International League of association of Rheumatology (ILAR) criteria, seen in rheumatology consultation or hospital. Sociodemographic and clinical data of the patients were collected. Bone mineral density of patients (BMD g/cm2) was measured by DXA X-ray Lunar Prodigy scanner. The disease activity was assessed by the number of painful joints (IA), swollen joint (SI), visual analogical scale measured by physician and patient vasP and VASp, biological markers of inflammation: the sedimentation rate (ESR) and C-reactive protein (CRP). BMD was measured in two sites: the lumbar spine (L1, L4) and the whole body. Lean and fat mass were measured by the same device in the whole body and expressed in grams. Results 33 patients were included, the mean of their age was 10±4.35 years old, with a male predominance (54.5%), the median of disease evolution was 2 (1 - 4.5) years. 24% had a systemic JIA, 27% had an oligoarticular JIA and 48% had a polyarticular JIA. The median of painful joints and synovial joint were respectively 3 (1-9) and 1 (0-3).The mean of DAS 28 was 5, 34±1.11 The mean of ESR was 37±18, with a median of CRP, VASP and VASp were respectively 20mg (10.5 to 40), 20 (10-50) and 20 (10-40). The median of BMD in the whole body, lumbar spine, lean mass and fat mass were respectively 0.720 g/cm2 (0700-0900) 0.620 g/cm2 (0530-0900), 20.49g (15.96-33.45) and 4.97g (3.63-15.09). We did not find a statistically significant association between gender and disease activity evaluated by the DAS28, articular index, synovial Index, VASP, VASp, ESR and CRP with p respectively at (p=0.79, p=0.068, p=0.75, p=0.75, p=0.71, p=0.80, p=0.73). There are also no statistically significant association between gender and lean body mass, fat mass, lumbar spineBMD or BMD of the whole body with p respectively at (p=0.39, p=0.99 p=0.29, p=0.65). Conclusions This study suggests that the gender of the patient does not influence the disease activity or body composition and BMD of patients. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5839