Abstract:BackgroundLiver abnormalities, particularly non-alcoholic fatty liver disease (NAFLD) are strongly associated with psoriatic arthritis (PsA). In the last decades, the possible hepatotoxic effects of methotrexate in PsA have been studied, however, up to date, the results are controversial.Objectives1) to evaluate the liver damage risk in PsA patients and its relationship with clinical features of the disease; 2) to determine the influence of cumulative doses of methotrexate byin vivoandin vitroapproaches.Method… Show more
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