A (μ-O)(μ-Br)ReIV2 metal–metal triple bond complex with a bridging tridentate ligand: Synthesis, structure and DFT study

Mukiza, Janvier; Gerber, Thomas; Hosten, Eric C.; Taherkhani, Farid; Nahali, M.

doi:10.1016/j.inoche.2014.09.005

Cited by 7 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The [13]. In this compound, the 5-amino group is un-coordinated, and again bridging by aoa 2À occurs via the same donor atoms as with or 2À in compound 1.…”

Section: Synthesis Spectroscopic and Electrochemical Datamentioning

confidence: 91%

Dimeric rhenium(IV) and monomeric rhenium(I) and (V) complexes of orotic acid

2015

Self Cite

View full text Add to dashboard Cite

“…The [13]. In this compound, the 5-amino group is un-coordinated, and again bridging by aoa 2À occurs via the same donor atoms as with or 2À in compound 1.…”

Section: Synthesis Spectroscopic and Electrochemical Datamentioning

confidence: 91%

Dimeric rhenium(IV) and monomeric rhenium(I) and (V) complexes of orotic acid

2015

Self Cite

View full text Add to dashboard Cite

“…Rhenium (Re) and technetium (Tc) are located in Group VII on the Periodic Table of elements and have comparable atomic radii, and consequently display similar coordination chemistry [11]. Therefore, the chemistry of rhenium is used for modelling one of technetium [9,10]. Due to their location in the middle of the d-block of transition metals, Re and Tc exhibit the properties of both early and later transition metals [9,11,12], and display the oxidation state which varies from − 1 to + 7 [12].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the chemistry of rhenium is used for modelling one of technetium [9,10]. Due to their location in the middle of the d-block of transition metals, Re and Tc exhibit the properties of both early and later transition metals [9,11,12], and display the oxidation state which varies from − 1 to + 7 [12]. The chemistry of Re and Tc is continuing to attract the researchers due to the potential application of these elements in nuclear medicine [13,11].…”

Section: Introductionmentioning

confidence: 99%

Monomeric and dimeric complexes of pyrimidine-4,6-dicarboxylic acid with organometallic fac-[M(CO)3]+ (M = Re and 99mTc) core as radiopharmaceutical probes

Mukiza,

Habarurema,

Sezirahiga

et al. 2024

Preprint

View full text Add to dashboard Cite

The current study describes the synthesis of monomeric and dimeric complexes of pyrimidine-4,6-dicarboxylic acid (H2pmdc) ligand with the organometallic fac-[M(CO)3]+ (M = Re and 99mTc) core which are the model for future design of imaging, therapeutic and theranostic radiopharmaceuticals. Monomeric complexes [M(CO)3(OH2)(Hpmdc)] (M = Re (1) and 99mTc (2)) were formed from the reaction of H2pmdc with [Re(CO)5Br] and [99mTc(CO)3(OH2)3]+ in aqueous solution respectively. The reaction of [Re(CO)5Br] with H2pmdc in ethanol (EtOH) led to the monomeric complex [Re(CO)3(OH2)(etpmdc)] (3), where etpmdc− is 6-(ethoxycarbonyl)pyrimidine-4-carboxylate anion which was formed from the mono-esterification of H2pmdc in parallel with its coordination to the fac-[Re(CO)3]+ unit. Dimeric complex (Et3NH)2[(µ-pmdc)2(Re(CO)3)2 (4) was obtained from the reaction of [Re(CO)5Br] with H2pmdc in water with addition of triethylamine (Et3N) as supporting base. The chemical identification of 1, 3 and 4 was achieved by using 1HNMR, 13CNMR, IR, ESI-MS and elemental analysis. Complex 3 was furtherly identified by using single crystal X-ray crystallography. The structural similarities of 1 and 2 was assessed by coinjection in the HPLC with UV/Vis detection coupled with a γ-detector followed by comparison of retention times of the γ-peak of 2 and the UV-peak of 1 which allowed unambiguous identification of 2. Heterodinuclear 99mTc/Re complex [(µ-pmdc)2(Re(CO)3)(99mTc(CO)3)2)]2− (5) was formed by reacting H2pmdc with [99mTc(CO)3(OH2)3]+ and [Re(CO)5Br] in aqueous solution. In parallel, the reaction also yielded complexes 1 and 2. The formation of 5 was assessed by injection in the HPLC with UV/Vis detection coupled with a γ-detector which displayed the radiochemical peak with the corresponding UV peak equivalent to that of the homologous non-radioactive complex 4.

show abstract