Complexes of orotic acid and derivatives with the fac-[M(CO)3]+ (M = Re and 99Tc/99mTc) core as radiopharmaceutical probes

Monomeric and dimeric complexes of pyrimidine-4,6-dicarboxylic acid with organometallic fac-[M(CO)3]+ (M = Re and 99mTc) core as radiopharmaceutical probes

“…To the best of our knowledge, the complexes [Re(CO) 3 (OH 2 )(Hpmdc)] ( 1) and [ 99m Tc(CO) 3 (OH 2 )(Hpmdc)] (2) are the rst reported rhenium and technetium complexes with pyrimidine-4,6-dicarboxylic acid (H 2 pmdc) ligand. Due to the lability of aqua-ligand, complexes 1, 2 and 3 are biologically important as aqua-ligand have been identi ed to exchange with a variety of biological molecules in biological system [19]. Such exchange shall not affect the rest part of complexes 1, 2 and 3 as result of high kinetic and thermodynamic stability of complexes based on the organometallic fac-[M(CO) 3 ] + (M = Re and Tc) unit, granting the potential application of these complexes as radiopharmaceutical probes.…”

“…The fac-[M(CO) 3 ] + core (M = Re and Tc) complexes with pyrimidine nucleoside derivatives have been reported and provided a convenient platform for drugs development [27]. Recently, complexes of the fac-[M(CO) 3 ] + (M = Re and 99 Tc/ 99m Tc) core with pyrimidine based ligands typically orotic acid and its derivatives have been reported [19]. The current study highlights on the fac-[M(CO) 3 ] + (M = Re and 99m Tc) core complexes with pyrimidine-4,6-dicarboxylic acid (H 2 pmdc) (Fig.…”

“…Organometallic fac-[M(CO) 3 ] + (M = Re and Tc) core dominates the chemistry of rhenium(I) and technetium(I), and it is well known by its small size, three vacant coordination sites and three exible and facially arranged CO ligands [11,[17][18][19]. The fac-[M(CO) 3 ] + (M = Re and Tc) core displays d 6 and low-spin electronic con guration, and its complexes are characterized by a distorted octahedral geometry and high kinetic and thermodynamic stability [18][19][20].…”

“…Organometallic fac-[M(CO) 3 ] + (M = Re and Tc) core dominates the chemistry of rhenium(I) and technetium(I), and it is well known by its small size, three vacant coordination sites and three exible and facially arranged CO ligands [11,[17][18][19]. The fac-[M(CO) 3 ] + (M = Re and Tc) core displays d 6 and low-spin electronic con guration, and its complexes are characterized by a distorted octahedral geometry and high kinetic and thermodynamic stability [18][19][20]. It is routinely coordinate to different chelating ligands leading to the complexes which structurally vary from monomers to ligand-bridged multimers, and even from metal-metal multiply bonded multimers to clusters [11,[17][18][19].…”

“…The fac-[M(CO) 3 ] + (M = Re and Tc) core displays d 6 and low-spin electronic con guration, and its complexes are characterized by a distorted octahedral geometry and high kinetic and thermodynamic stability [18][19][20]. It is routinely coordinate to different chelating ligands leading to the complexes which structurally vary from monomers to ligand-bridged multimers, and even from metal-metal multiply bonded multimers to clusters [11,[17][18][19]. Organometallic complexes based on the fac-[M(CO) 3 ] + (M = Re and Tc) core have attracted much attention due particularly to their possible application in the development of radiopharmaceuticals which involve imaging 99m Tc and therapeutic…”