A ZnO-doped adhesive reduced collagen degradation favouring dentine remineralization

Toledano, Manuel; Yamauti, Mónica; Ruiz-Requena, María Estrella; Osorio, Raquel

doi:10.1016/j.jdent.2012.05.007

Cited by 69 publications

(56 citation statements)

References 41 publications

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“…The same happens to adhesives containing zinc 114,138,139,140,141 or MMP-inhibiting monomers or solvents: polymerizable quaternary ammonium methacrylates (QAMs; e.g. 12-Methacryloyloxydodecylpyridinium bromide / MDPB), 66,68,93,125,142,143 incorporated into the primer of Clearfil Protect Bond, Kuraray,(6) and dimethyl sulfoxide (DMSO), 144,145,146 correspondingly.…”

Section: Enzymatic Inhibitorsmentioning

confidence: 99%

Bonding efficiency and durability: current possibilities

et al. 2017

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Bonding plays a major role in dentistry nowadays. Dental adhesives are used in association with composites to solve many restorative issues. However, the wide variety of bonding agents currently available makes it difficult for clinicians to choose the best alternative in terms of material and technique, especially when different clinical situations are considered. Moreover, although bonding agents allow for a more conservative restorative approach, achieving a durable adhesive interface remains a matter of concern, and this mainly due to degradation of the bonding complex in the challenging oral environment. This review aims to present strategies that are being used or those still in development which may help to prevent degradation. It is fundamental that professionals are aware of these strategies to counteract degradation as much as possible. None of them are efficient to completely solve this problem, but they certainly represent reasonable alternatives to increase the lifetime of adhesive restorations.

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Section: Enzymatic Inhibitorsmentioning

confidence: 99%

Bonding efficiency and durability: current possibilities

et al. 2017

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“…106,107 Zinc-containing adhesives may improve hybrid layer durability and preserve bond strength and may even induce dentin remineralization at the bonded interface. [108][109][110] The effect is believed to occur via zinc binding to collagen, which protects the cleavage sites of MMPs. 100 However, excessive presence of zinc ions may jeopardize the bonding performance of MDPcontaining SE adhesives.…”

Section: Enzyme Inhibitorsmentioning

confidence: 99%

Dentin Bonding: Can We Make it Last?

Tjäderhane

2015

Operative Dentistry

170

144

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Bond strength to dentin decreases with time because of the hydrolytic degradation of the hybrid layer components dentin collagen and adhesive resin. Inhibition of enzymes responsible for the collagen degradation may improve the bond strength durability. SUMMARYIn dentin bonding, contemporary dental adhesive systems rely on formation of the hybrid layer, a biocomposite containing dentin collagen and polymerized resin adhesive. They are usually able to create at least reasonable integrity of the hybrid layer with high immediate bond strength. However, loss of dentinbonded interface integrity and bond strength is commonly seen after aging both in vitro and in vivo. This is due to endogenous collagenolytic enzymes, matrix metalloproteinases, and cysteine cathepsins, responsible for the timedependent loss of hybrid layer collagen. In addition, the hydrophilic nature of adhesive systems creates problems that lead to suboptimal hybrid layers. These problems include, for example, insufficient resin impregnation of dentin, phase separation, and a low rate of polymerization, all of which may reduce the longevity of the bonded interface.Preservation of the collagen matrix integrity by inhibition of endogenous dentin proteases is key to improving dentin bonding durability. Several approaches to retain the integrity of the hybrid layer and to improve the long-term dentin bond strength have been tested. These include the use of enzyme inhibitors, either separately or as incorporated into the adhesive resins; increase of collagen resistance to enzymatic degradation; and elimination of water from the interface to slow down or eliminate hydrolytic loss of the hybrid layer components. This review looks at the principles, current status, and future of the different techniques designed to prevent the loss of hybrid layer and bond strength.

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“…These effects make zinc attractive for use as a therapeutic agent in the fields of hard and soft tissue engineering. Zinc is widely used in dentistry and has been experimentally included into a resin adhesive, not only reducing MMPs-mediated collagen degradation, but also seeming to induce dentin remineralization at the bonded interface [Toledano et al, 2012b[Toledano et al, , 2013.…”

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Zinc Induces Apatite and Scholzite Formation during Dentin Remineralization

Osorio

Cabello

et al. 2014

Caries Res

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The aim of this study was to ascertain whether zinc may improve the repair ability of demineralized dentin. Dentin disks were demineralized by phosphoric acid during 15 s and immersed in artificial saliva, remineralizing solution, a zinc chloride solution and a zinc oxide solution. Dentin specimens were analyzed after 24 h and 1 month of storage. Surface morphology was assessed by atomic force and scanning electron microscopy, mechanical properties were analyzed by nanohardness testing in a TriboIndenter, and chemical changes at the surfaces were determined by X-ray diffraction, Raman and energy-dispersive elemental analyses. After phosphoric acid application, dentin was only partially demineralized. Demineralized dentin was remineralized after 24 h of storage in any of the tested solutions (nanohardness increased and hydroxylapatite formation was detected by Raman). Remineralization was maintained up to 1 month in dentin stored in remineralizing solution, zinc chloride and zinc oxide. Zinc and phosphate were important for hydroxylapatite homeostasis. Scholzite formation was encountered in dentin stored in zinc-containing solutions. Zinc might allow to reach the balance between dentin demineralization and remineralization processes.

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A ZnO-doped adhesive reduced collagen degradation favouring dentine remineralization

Cited by 69 publications

References 41 publications

Bonding efficiency and durability: current possibilities

Bonding efficiency and durability: current possibilities

Dentin Bonding: Can We Make it Last?

Zinc Induces Apatite and Scholzite Formation during Dentin Remineralization

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