A young adult with a fulminant Staphylococcus aureus infection and multiple thrombi

Martin, Eric S.; Frandah, Wesam; Raj, Rishi; Nugent, Kenneth

doi:10.4081/cdr.2011.e16

Cited by 2 publications

(2 citation statements)

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“…The Active Bacterial Core Surveillance Staphylococcal pneumonia usually develops after viral infections of the lower respiratory tract which allow staphylococcal adherence to epithelial surfaces and invasion. 3 Gillet and coworker reported studies on 16 patients with necrotizing pneumonia secondary to Staphylococcus aureus strains producing the Panton-Valentine leukocidin (PVL). 1 These patients were young with a median age of 15 and healthy.…”

Section: What Is the Epidemiology Of Methicillin-resistant Staphylococcus Aureus Infections In The Us? What Are The Usual Clinical Presenmentioning

confidence: 99%

“…We recently helped care for a fatal case of CA-MRSA pneumonia, and this stimulated us to review the clinical and microbiological characteristics of CA-and HA-MRSA infections. 3 We approached this review by answering important clinical questions about these infections to update clinicians who take care of patients with severe infections, especially pneumonia, in intensive care units (ICUs).…”

Section: Introductionmentioning

confidence: 99%

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Clinical and microbiological characteristics of communityacquired methicillin-resistant Staphylococcus aureus pneumonia

et al. 2012

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Methicillin-resistant Staphylococcus aureus (MRSA) infections now occur in healthy adults in community settings. We searched the PubMed database to identify relevant articles on the clinical presentation, epidemiology, virulence, and treatment of community-acquired MRSA (CA-MRSA) infections, including pneumonia. This information was summarized in a narrative review.MRSA infections cause approximately 30 infections per 100,000 people per year in the USA, and twenty percent of these infections are secondary to CA-MRSA. These community-acquired infections often involve the skin and subcutaneous tissue but can also involve visceral tissues such as the lung and bone. The overall mortality in patients with invasive disease is approximately 10%; it approaches 50% in patients with pneumonia. The bacterial isolates from these infections have the staphylococcal chromosome cassette mec types 4 and 5. This genetic characteristic produces beta-lactam resistance and helps distinguish these isolates from hospital- acquired MRSA, which usually have mec types 1-3. Some CA-MRSA isolates release the Panton-Valentine leukocidin (PVL), which causes neutropenia and tissue necrosis; other toxins also contribute to the virulence of these infections. Empiric therapy should include vancomycin or linezolid. CA-MRSA infections can have fulminant courses and high mortality rates. Physicians should consider these infections as possible emergencies with a high risk for organ system failure and shock

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Section: What Is the Epidemiology Of Methicillin-resistant Staphylococcus Aureus Infections In The Us? What Are The Usual Clinical Presenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%