A YAC Contig of the Human CC Chemokine Genes Clustered on Chromosome 17q11.2

Naruse, Kuniko; Ueno, Miki; Satoh, Takaaki; Nomiyama, Hisayuki; Tei, Hajime; Takeda, Masaharu; Ledbetter, David H.; Coillie, Els Van; Opdenakker, Ghislain; Gunge, Norio; Sakaki, Yoshiyuki; M, Iio; Miura, Retsu

doi:10.1006/geno.1996.0274

Cited by 115 publications

(70 citation statements)

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“…Many of the CC chemokines in this cluster bind the same receptors, namely CCR1, CCR2, CCR3, and CCR5. Interestingly, although the gene encoding CCL1 is located in this chemokine gene cluster (18) it is the only CC chemokine from this cluster that specifically binds CCR8, or in other words, has a single ligand/receptor relationship.…”

Section: Discussionmentioning

confidence: 99%

CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and Langerhans-Type Dendritic Cells to Sites of Atopic Skin Inflammation

Gombert

Dieu-Nosjean

Winterberg

et al. 2005

The Journal of Immunology

184

142

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Atopic dermatitis represents a chronically relapsing skin disease with a steadily increasing prevalence of 10–20% in children. Skin-infiltrating T cells, dendritic cells (DC), and mast cells are thought to play a crucial role in its pathogenesis. We report that the expression of the CC chemokine CCL1 (I-309) is significantly and selectively up-regulated in atopic dermatitis in comparison to psoriasis, cutaneous lupus erythematosus, or normal skin. CCL1 serum levels of atopic dermatitis patients are significantly higher than levels in healthy individuals. DC, mast cells, and dermal endothelial cells are abundant sources of CCL1 during atopic skin inflammation and allergen challenge, and Staphylococcus aureus-derived products induce its production. In vitro, binding and cross-linking of IgE on mast cells resulted in a significant up-regulation of this inflammatory chemokine. Its specific receptor, CCR8, is expressed on a small subset of circulating T cells and is abundantly expressed on interstitial DC, Langerhans cells generated in vitro, and their monocytic precursors. Although DC maintain their CCR8+ status during maturation, brief activation of circulating T cells recruits CCR8 from intracytoplamic stores to the cell surface. Moreover, the inflammatory and atopy-associated chemokine CCL1 synergizes with the homeostatic chemokine CXCL12 (SDF-1α) resulting in the recruitment of T cell and Langerhans cell-like DC. Taken together, these findings suggest that the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin inflammation.

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Section: Discussionmentioning

confidence: 99%

CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and Langerhans-Type Dendritic Cells to Sites of Atopic Skin Inflammation

Gombert

Dieu-Nosjean

Winterberg

et al. 2005

The Journal of Immunology

184

142

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“…The human genes for many CC chemokines are known to be clustered on chromosome 17 in the region 17qll -q21 (Naruse et al, 1996). A yeast artificial chromosome covering this region was reported to contain the genes for 10 known chemokines, plus four additional sequences.…”

Section: Discussionmentioning

confidence: 99%

“…Analysis of three adjacent YACs showed that the existing CC chemokine genes could be clustered into two groups. The first, called the MCP group, contains the genes for MCP-I, MCP-3, 1-309 and MCP-4 (NCC-1 ; Naruse et al, 1996). Further towards the telomere there is a second group containing the genes for RANTES, MIP-IP, MIP-5/NCC3, HCC-I (NCC-2), MIP-lcx and a chemokine for which no activity has been reported, NCC-4.…”

Section: Discussionmentioning

confidence: 99%

Characterisation of Macrophage Inflammatory Protein‐5/Human CC Cytokine‐2, A Member of the Macrophage‐Inflammatory‐Protein Family of Chemokines

Coulin¹,

Power²,

Alouani³

et al. 1997

European Journal of Biochemistry

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A human monocyte-activating CC chemokine has been identified based on sequences in an expressed sequence tag (EST) cDNA database. The protein shows highest sequence identity to the macrophage inflammatory protein (MIP) group of chemokines, particularly MIP-3 (76.7 %) and MIP-la (75.4%), and has been named MIP-5. Model building confirms that the protein has a similar three dimensional structure to other chemokines, but has an additional third disulphide bond. Northern blot analysis and reversetranscriptase PCR show that the mRNA for MIP-5 is expressed at a high levels in liver, intestine and in lung leukocytes. MIP-5 induces chemotaxis of human monocytes, T-lymphocytes and, to a lesser degree, eosinophils at nanomolar concentrations ; it has no effect on neutrophil migration. In receptor-binding assays, MIP-5 shows IC,, values of 12 nM for competition with '251-MIP-la for binding to CC-chemokine receptor (CCR)l, and 2.5 nM for competition with '"I-MCP-3 for binding to CCR3. It shows no ability to compete with ligand for binding to the two interleukin (1L)-8 receptors (CXC-chemokine receptors 1 and 2) or to CCR2, CCR4 or CCRS. Consistent with this binding data, MIP-5 was only able to induce calcium fluxes in CHO cells stably transfected with CCRI or CCR3.

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“…Whereas MCP-3 cDNA was cloned by degenerate primer polymerase chain reaction (PCR) [15], such attempts failed for MCP-2. Therefore, the MCP-2 gene was first cloned [16] from the CC chemokine YAC contig on the human chromosomal region 17q11.2 [17]. Thereafter, a full-size ϳ900-bp MCP-2 cDNA was isolated from a bone marrow cDNA library [18] and a 5Ј-end-extended MCP-2 cDNA variant was cloned from human testis tissue [19].…”

Section: Introductionmentioning

confidence: 99%

Transcriptional control of the human MCP-2 gene promoter by IFN-γ and IL-1β in connective tissue cells

Coillie

Aelst

Fiten

et al. 1999

Journal of Leukocyte Biology

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A YAC Contig of the Human CC Chemokine Genes Clustered on Chromosome 17q11.2

Cited by 115 publications

References 1 publication

CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and Langerhans-Type Dendritic Cells to Sites of Atopic Skin Inflammation

CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and Langerhans-Type Dendritic Cells to Sites of Atopic Skin Inflammation

Characterisation of Macrophage Inflammatory Protein‐5/Human CC Cytokine‐2, A Member of the Macrophage‐Inflammatory‐Protein Family of Chemokines

Transcriptional control of the human MCP-2 gene promoter by IFN-γ and IL-1β in connective tissue cells

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