Transcriptional control of the human MCP-2 gene promoter by IFN-γ and IL-1β in connective tissue cells

Coillie, Els Van; Aelst, Ilse Van; Fiten, Pierre; Billiau, Alfons; Damme, Jo Van; Opdenakker, Ghislain

doi:10.1002/jlb.66.3.502

Cited by 16 publications

(10 citation statements)

References 52 publications

(79 reference statements)

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“…The NF-B binding sequence is a common element within inflammatory cytokine promoters, and, interestingly, all of the cytokines shown to be regulated in this report contain NF-B binding sites within their promoters (19,41,51). HCMV infection has been shown to result in NF-B activation, and infection with UV-inactivated HCMV enhances NF-B binding activity (15,57).…”

Section: Discussionmentioning

confidence: 73%

Human Cytomegalovirus Immediate-Early 2 Protein IE86 Blocks Virus-Induced Chemokine Expression

Taylor

Bresnahan

2006

J Virol

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The effect of human cytomegalovirus (HCMV) gene expression on cytokine (beta interferon) and chemokine (RANTES, MIG, MCP-2, MIP-1␣, and interleukin-8) expression was examined. We demonstrate that HCMV gene expression is required to suppress the transcriptional induction of these cytokines and that the HCMV immediate-early 2 gene product IE86 can effectively block the expression of cytokines and proinflammatory chemokines during HCMV and Sendai virus infection. Additionally, we present data on viral mutants and ectopic protein expression which demonstrate that pp65, another identified HCMV cytokine antagonist, is not involved in regulating these proinflammatory cytokines. This is the first report to demonstrate that IE86 can act to suppress virus-induced proinflammatory cytokine transcript expression, extending the antiviral properties of this multifunctional viral protein.

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Section: Discussionmentioning

confidence: 73%

Human Cytomegalovirus Immediate-Early 2 Protein IE86 Blocks Virus-Induced Chemokine Expression

Taylor

Bresnahan

2006

J Virol

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“…It has been shown that the proinflammatory cytokines IFN‐ γ and IL‐1 β are good inducers of CCL8 (Van Coillie et al. ; Struyf et al. ).…”

Section: Discussionmentioning

confidence: 99%

The CC chemokines CCL8, CCL13 and CCL20 are local inflammatory biomarkers of HLA‐B27‐associated uveitis

El‐Asrar

Berghmans

Al-Obeidan

et al. 2018

Acta Ophthalmologica

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Purpose: To determine the concentrations of the CC chemokines CCL2, CCL7, CCL8, CCL11, CCL13, CCL20, CCL24 and CCL26 in aqueous humour (AH) samples from patients with specific uveitic entities. Methods: Aqueous humour samples from patients with active uveitis associated with Behc ßet's disease (BD) (n = 13), sarcoidosis (n = 8), HLA-B27-related inflammation (n = 12), Vogt-Koyanagi-Harada (VKH) disease (n = 12) and control patients (n = 9) were assayed with the use of a multiplex assay. Results: When considering all uveitis patients as one group, all chemokine levels except CCL2 were significantly increased compared to controls. CCL8, CCL13 and CCL20 were the most strongly upregulated, 48-fold, 118-fold and 173-fold, respectively, above control AH levels. CCL8 and CCL13 levels were significantly higher in HLA-B27-associated uveitis than in sarcoidosis and VKH disease. CCL20 levels were significantly higher in HLA-B27-associated uveitis than in BD, sarcoidosis and VKH disease. In addition, CCL20 levels were significantly higher in BD than in VKH disease. In HLA-B27-associated uveitis, CCL8, CCL13 and CCL20 were upregulated 111-fold, 255-fold and 465-fold, respectively, compared with controls. CCL8, CCL13 and CCL20 levels were significantly higher in nongranulomatous uveitis (BD and HLA-B27-associated uveitis) than in granulomatous uveitis (sarcoidosis and VKH disease). Conclusion: Immune responses mediated by CCL8, CCL13 and CCL20 appear to be more potent in nongranulomatous uveitis, particularly in HLA-B27associated uveitis.

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“…Connective tissue cells, in particular fibroblasts, are gaining increasing interest in immunobiology (Van Coillie et al 1999). Although IL-17 has been studied in other cell types as a triggering cytokine, less is known of signaling in fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes

Zheng

Dillen

et al. 2009

Immunobiology

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Transcriptional control of the human MCP-2 gene promoter by IFN-γ and IL-1β in connective tissue cells

Cited by 16 publications

References 52 publications

Human Cytomegalovirus Immediate-Early 2 Protein IE86 Blocks Virus-Induced Chemokine Expression

Human Cytomegalovirus Immediate-Early 2 Protein IE86 Blocks Virus-Induced Chemokine Expression

The CC chemokines CCL8, CCL13 and CCL20 are local inflammatory biomarkers of HLA‐B27‐associated uveitis

Interleukin-17 regulates chemokine and gelatinase B expression in fibroblasts to recruit both neutrophils and monocytes

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