2020
DOI: 10.1101/2020.02.02.926782
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A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection

Abstract: Physical and chemical technologies have been continuously progressing advances of neuroscience research. The development of research tools for closed-loop control and monitoring neural activities in behaving animals is highly desirable. In this paper, we introduce a wirelessly operated, miniaturized microprobe system for optical interrogation and neurochemical sensing in the deep brain. Via epitaxial liftoff and transfer printing, microscale light emitting diodes (micro-LEDs) as light sources, and poly(3,4-eth… Show more

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Cited by 3 publications
(2 citation statements)
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“…Meanwhile, the combination of electrophysiological activities, PbtO2 and blood oxygenations will foster a more profound understanding of the neurovascular and neurometabolic coupling 64,65 . In the future, the PbtO2 probe can integrate with other microscale devices for detecting electrophysiological signals 66 , calcium fluorescence 67,68 , neurotransmitters 69,70 and temperature 71,72 , to realize multi-modal neural sensing. Additionally, the PbtO2 sensing technique can collaborate with optogenetic and non-genetic stimulations 73,74 , to achieve closed-loop interrogation.…”
Section: Discussionmentioning
confidence: 99%
“…Meanwhile, the combination of electrophysiological activities, PbtO2 and blood oxygenations will foster a more profound understanding of the neurovascular and neurometabolic coupling 64,65 . In the future, the PbtO2 probe can integrate with other microscale devices for detecting electrophysiological signals 66 , calcium fluorescence 67,68 , neurotransmitters 69,70 and temperature 71,72 , to realize multi-modal neural sensing. Additionally, the PbtO2 sensing technique can collaborate with optogenetic and non-genetic stimulations 73,74 , to achieve closed-loop interrogation.…”
Section: Discussionmentioning
confidence: 99%
“…To address the size and density limitations, smaller LED chips have been custom-designed and fabricated. In this method, first, an array of micro-LEDs are fabricated on a sapphire substrate and the flexible probe shanks are fabricated on a separate substrate and then the micro-LEDs with dimensions as small as 50 μm × 50 μm × 6.45 μm are transferred to the polymer substrate using a laser liftoff (LLO) process, where an excimer laser is used to detach GaN from sapphire [ 67 , 68 , 69 •• ]. The flip-chip bonding process requires precise alignment and is usually serial, which would limit the scalability and throughput of the packaging process.…”
Section: Active Flexible Neurophotonic Implantsmentioning
confidence: 99%