Flexible optoelectric neural interfaces

Ahmed, Z.; Reddy, Jay W.; Malekoshoaraie, Mohammad H.; Hassanzade, Vahid; Kimukin, Ïbrahim; Jain, Vishal; Chamanzar, Maysamreza

doi:10.1016/j.copbio.2021.11.001

Cited by 12 publications

(13 citation statements)

References 66 publications

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“… 11 , 12 More detailed reviews about these advanced multimodal platforms for rodents can be found elsewhere. 13 , 14 , 15 Translating these advances to clinical testing often requires preclinical studies in large animal models that are closer to humans. Nonhuman primates in particular have evolutionary very similar behavior and cognitive functions to humans, thus making them an important model of study.…”

Section: Introductionmentioning

confidence: 99%

Large-scale multimodal surface neural interfaces for primates

Belloir¹,

Vargo²,

Ahmed³

et al. 2023

iScience

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Section: Introductionmentioning

confidence: 99%

Large-scale multimodal surface neural interfaces for primates

Belloir¹,

Vargo²,

Ahmed³

et al. 2023

iScience

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“…Moreover, the substrate usually has a decisive influence on the mechanical properties, form factor and biocompatibility of the entire electrode . PDMS, PI, and Parylene C − are commonly used polymer substrates.…”

Section: Strategies To Reduce Immune Response Of Implantable Neural M...mentioning

confidence: 99%

Implantable Neural Microelectrodes: How to Reduce Immune Response

Xiang,

Zhao,

Cheng

et al. 2024

ACS Biomater. Sci. Eng.

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Implantable neural microelectrodes exhibit the great ability to accurately capture the electrophysiological signals from individual neurons with exceptional submillisecond precision, holding tremendous potential for advancing brain science research, as well as offering promising avenues for neurological disease therapy. Although significant advancements have been made in the channel and density of implantable neural microelectrodes, challenges persist in extending the stable recording duration of these microelectrodes. The enduring stability of implanted electrode signals is primarily influenced by the chronic immune response triggered by the slight movement of the electrode within the neural tissue. The intensity of this immune response increases with a higher bending stiffness of the electrode. This Review thoroughly analyzes the sequential reactions evoked by implanted electrodes in the brain and highlights strategies aimed at mitigating chronic immune responses. Minimizing immune response mainly includes designing the microelectrode structure, selecting flexible materials, surface modification, and controlling drug release. The purpose of this paper is to provide valuable references and ideas for reducing the immune response of implantable neural microelectrodes and stimulate their further exploration in the field of brain science.

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“…Traditionally, these neural probes have been implemented on rigid substrates such as silicon. To minimize damage and the tissue response and make these neural probes viable for chronic long-term interfacing with the brain, polymer substrates such as Parylene C 5,6 , Polyimide 7,8 and SU8 9,10 have also been used to implement exible neural probes 11 . Other functionalities such as electrical and optical microstimulation 6,12 as well as chemical sensing 13,14 have also been added to these neural probes.…”

Section: Introductionmentioning

confidence: 99%

Fully flexible high-density implantable neural probes for electrophysiology recording and controlled neurochemical modulation

Chamanzar

Malekoshoaraie

et al. 2023

Preprint

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Targeted delivery of neurochemicals and biomolecules for neuromodulation of brain activity is a powerful technique that, in addition to electrical recording and stimulation, enables a more thorough investigation of neural circuit dynamics. We have designed a novel flexible neural implant capable of controlled, localized chemical stimulation and high-density electrophysiology recording. To minimize tissue damage and response, the neural probe was implemented with a small cross-sectional dimension using planar micromachining processes on Parylene C, a mechanically flexible, biocompatible substrate. The probe shank features two large microelectrodes (chemical sites) for drug loading and sixteen small microelectrodes for electrophysiology recording to monitor neuronal response to drug release. To reduce the impedance while keeping the size of the microelectrodes small, poly(3,4-ethylenedioxythiophene) (PEDOT) was electrochemically coated on recording microelectrodes. In addition, PEDOT doped with mesoporous sulfonated silica nanoparticles (SNP) was used on chemical sites to achieve controlled, electrically-actuated drug loading and releasing. Different neurotransmitters, including glutamate (Glu), and gamma-aminobutyric acid (GABA), were incorporated into the SNPs and electrically triggered to release repeatedly. An in vitro experiment was conducted to quantify the stimulated release profile by applying a sinusoidal voltage (0.5 V, 2 Hz). The flexible neural probe was implanted in the barrel cortex of the wild-type Sprague Dawley rats. As expected due to their excitatory and inhibitory effects, Glu and GABA release caused a significant increase and decrease in neural activity, respectively, which was recorded by the recording microelectrodes. This novel flexible neural probe technology, combining on-demand chemical release and high-resolution electrophysiology recording, is an important addition to the neuroscience toolset used to dissect neural circuitry and investigate neural network connectivity.

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Flexible optoelectric neural interfaces

Cited by 12 publications

References 66 publications

Large-scale multimodal surface neural interfaces for primates

Large-scale multimodal surface neural interfaces for primates

Implantable Neural Microelectrodes: How to Reduce Immune Response

Fully flexible high-density implantable neural probes for electrophysiology recording and controlled neurochemical modulation

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