A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome

Giacco, Rosalba; Costabile, Giuseppina; Pepa, Giuseppe Della; Anniballi, G.; Griffo, Ettore; Mangione, Anna; Cipriano, Paola; Viscovo, D.; Clemente, Gennaro; Landberg, Rikard; Pacini, Giovanni; Rivellese, Angela Albarosa; Riccardi, Gabriele

doi:10.1016/j.numecd.2014.01.007

Cited by 120 publications

(81 citation statements)

References 33 publications

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“…Specifically, it has been shown that a diet rich in vegetables, fruits and whole cereals decreases both postprandial glucose and triglyceride-rich lipoproteins. 124,125 In addition, a meal high in fruit and fiber is associated with alterations in several factors which may result in improved postprandial glucose and lipid values and in restriction of inflammatory response. These alterations include higher proinsulin, insulin, C-peptide, GIP and peak GLP-1 secretion and lower plasma glucagon, dipeptidyl peptidase-IV (DPP-IV) and CD26 expression in mononuclear cells (MNC) compared to a high fat and carbohydrate meal.…”

Section: Dietary Modification and Exercisementioning

confidence: 99%

Postprandial dysmetabolism: Too early or too late?

Pappas¹,

Kandaraki²,

Tsirona³

et al. 2016

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postprandial dysmetabolism is a postprandial state characterized by abnormal metabolism of glucose and lipids and, more specifically, of elevated levels of glucose and triglyceride (Tg) containing lipoproteins. Since there is evidence that postprandial dysmetabolism is associated with increased cardiovascular mortality and morbidity, due to macro-and microvascular complications, as well as with conditions such as polycystic ovary syndrome (pCOS) and nonalcoholic fatty liver disease (NaFlD), it is recommended that clinicians be alert for early detection and management of this condition. management consists of a holistic approach including dietary modification, exercise and use of hypoglycemic and hypolipidemic medication aiming to decrease the postprandial values of circulating glucose and triglycerides. This review aims to explain glucose and lipid homeostasis and the impact of postprandial dysmetabolism on the cardiovascular system as well as to offer suggestions with regard to the therapeutic approach for this entity. however, more trials are required to prevent or reverse early and not too late the actual tissue damage due to postprandial dysmetabolism.

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Section: Dietary Modification and Exercisementioning

confidence: 99%

Postprandial dysmetabolism: Too early or too late?

Pappas¹,

Kandaraki²,

Tsirona³

et al. 2016

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“…20,21 The present analysis was carried out on the baseline data collected before starting the intervention. Overall, 116 men and women, aged between 40 and 65 years, with high body mass index (BMI) (27-35 kg/m 2 ) and waist circumference (WC) (men > 102 cm; women > 88 cm), were included in this study.…”

Section: Study Samplementioning

confidence: 99%

Urine 8-Isoprostane in Relation to Adiposity and Insulin Resistance in Individuals at High Cardiometabolic Risk

Costabile

Pepa²,

Bozzetto³

et al. 2015

Metabolic Syndrome and Related Disorders

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“…Recent research has indicated that consumption of whole grain and whole-grain products reduces the risks of obesity [1][2][3][4] and such widespread chronic diseases as Electronic supplementary material The online version of this article (doi:10.1007/s00216-015-9007-5) contains supplementary material, which is available to authorized users. cardiovascular disease [5][6][7], type II diabetes [5,7,8], and colorectal cancer [9][10][11]. It has been proposed that the unique phytochemicals in whole grain are responsible for these health benefits.…”

Section: Introductionmentioning

confidence: 99%

Use of fuzzy chromatography mass spectrometric (FCMS) fingerprinting and chemometric analysis for differentiation of whole-grain and refined wheat (T. aestivum) flour

et al. 2015

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A fuzzy chromatography mass spectrometric (FCMS) fingerprinting method combined with chemometric analysis has been established for rapid discrimination of whole-grain flour (WF) from refined wheat flour (RF). Bran, germ, endosperm, and WF from three local cultivars or purchased from a grocery store were studied. The state of refinement (whole vs. refined) of wheat flour was differentiated successfully by use of principal-components analysis (PCA) and soft independent modeling of class analogy (SIMCA), despite potential confounding introduced by wheat class (red vs. white; hard vs. soft) or resources (different brands). Twelve discriminatory variables were putatively identified. Among these, dihexoside, trihexoside, apigenin glycosides, and citric acid had the highest peak intensity for germ. Variable line plots indicated phospholipids were more abundant in endosperm. Samples of RF and WF from three cultivars (Hard Red, Hard White, and Soft White) were physically mixed to furnish 20, 40, 60, and 80 % WF of each cultivar. SIMCA was able to discriminate between 100 %, 80 %, 60 %, 40 %, and 20 % WF and 100 % RF. Partial least-squares (PLS) regression was used for prediction of RF-to-WF ratios in the mixed samples. When PLS models were used the relative prediction errors for RF-to-WF ratios were less than 6 %. Graphical Abstract Workflow of targeting discriminatory compounds by use of FCMS and chemometric analysis.

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A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome

Cited by 120 publications

References 33 publications

Postprandial dysmetabolism: Too early or too late?

Postprandial dysmetabolism: Too early or too late?

Urine 8-Isoprostane in Relation to Adiposity and Insulin Resistance in Individuals at High Cardiometabolic Risk

Use of fuzzy chromatography mass spectrometric (FCMS) fingerprinting and chemometric analysis for differentiation of whole-grain and refined wheat (T. aestivum) flour

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