Urine 8-Isoprostane in Relation to Adiposity and Insulin Resistance in Individuals at High Cardiometabolic Risk

Costabile, Giuseppina; Pepa, Giuseppe Della; Bozzetto, Lutgarda; AnnuzziGiovanni,; Vetrani, Claudia; Giacco, Rosalba; CorteGiuseppina, Della; Serena, ConteFrancesca; MarinoLucrezia, Di; Albarosa, RivelleseAngela

doi:10.1089/met.2014.0119

Cited by 12 publications

(9 citation statements)

References 25 publications

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“…When adjusting for it, however, the impact of oxidative stress marker on IR incidence was still evident. MetS, and waist circumference (originating in its components), most manifestly affected the development of IR, as corroborated by other investigators [15][16][17]. After adjustment for BMI, or waist circumference, no relationships plasma F2-isoprostanes with HOMA-IR were reported in longitudinal Park et al study, while in the other a cross-sectional study, relationship of urine 8-iso-PGF 2α was established as BMI-independent with regard to HOMA-IR only, although not with regard to IR [15,21].…”

Section: Discussionsupporting

confidence: 77%

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Potential roles of psychological and oxidative stress in insulin resistance: a cohort-based study

Janczura

Dropiński

Gielicz

et al. 2020

Diabetol Metab Syndr

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Background: The present study investigated the relationships between psychological stress indices and oxidative stress marker, also when combined with emergent insulin resistance (IR), in the non-diabetic, middle-aged subjects, exposed to frequent/chronic psychological stressors. Methods: Cross-sectional data from a cohort of non-diabetic police officers (n = 234; 19F), aged 27-56 years, were used. Plasma inflammatory (CRP, TNF-α), oxidative stress (free 8-iso-prostaglandin F 2α ; 8-iso-PGF 2α) markers, and insulin were measured. The value of homeostasis model assessment of IR index (HOMA-IR) was assumed the threshold value of IR, i.e. 2.04. Free cortisol in urine and perceived stress (psychological stress indices) were also measured. Results: In the IR subjects, most biochemical variables, inflammatory markers and urine cortisol were significantly higher, as compared to the non-IR ones. Psychological stress indices were associated with plasma 8-iso-PGF 2α [B = 0.139, 95% CI (0.048, 0.230), p = 0.002, and B = 0.007, 95% CI (0.0006, 0.014), p = 0.03; for perceived stress level and cortisol, respectively]. Positive associations were established between plasma 8-iso-PGF 2α [B = 0.069, 95% CI (0.016-0.120), p = 0.01] and urine cortisol [B = 0.003, 95% CI (0.0003, 0.005), p = 0.02] with HOMA-IR. Metabolic syndrome, as defined by IDF criteria, was established in 110 study subjects, whereas 136 of them were hypertensive. Waist circumference [B = 0.056, 95% CI (0.039, 0.074), p < 0.0001], and systolic blood pressure [B = 0.009, 95% CI (0.00003, 0.018), p = 0.04] were positively associated with HOMA-IR, whereas the association of HDL cholesterol [B = − 0.597, 95% CI (− 1.139, − 0.055), p = 0.03] was a negative one. Cortisol [OR = 1.007, 95% CI (1.002, 1.012), p = 0.006], and 8-iso-PGF 2α [OR = 1.103, 95% CI (1.010, 1.201), p = 0.02] affected the incidence of IR. After adjustment for metabolic syndrome (or its components), age, sex, and current smoking, the effects became non-significant. Out of metabolic syndrome components, waist circumference [OR 4.966, 95% CI (2.29, 10.751), p = 0.00004] and hypertriglyceridemia [OR 1.993, 95% CI (1.063, 3.736), p = 0.03] increased the chance of IR incidence. Conclusions: Both psychological stress indices were associated with oxidative stress, but only cortisol with HOMA-IR. In the subjects exposed to frequent/chronic psychological stressors, cortisol and oxidative stress marker affected IR incidence, being statistically attenuated, though, following adjustment for metabolic syndrome, or its components.

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Section: Discussionsupporting

confidence: 77%

“…Published data on oxidative stress in humans in relation to IR remain scarce and inconclusive. Some cross-sectional studies had demonstrated in humans a positive association between urine 8-iso-PGF 2α and IR, even though no such relationships were corroborated by other studies [15][16][17].…”

mentioning

confidence: 90%

Potential roles of psychological and oxidative stress in insulin resistance: a cohort-based study

Janczura

Dropiński

Gielicz

et al. 2020

Diabetol Metab Syndr

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“…The most representative vitamins in wholegrain are the B complex vitamins, ranging from one mg (for thiamin) to 11 mg (for nicotinic acid) in every 100 g of wholegrain; vitamin E is also present in a good quantity (two-to-seven mg/100 g wholegrain). Vitamin B complex may contribute to the regulation of hepatic glucose uptake [ 92 ], while vitamin E may be beneficial in reducing the oxidative stress and chronic low-grade inflammation associated with obesity, metabolic syndrome, and insulin resistance [ 93 , 94 , 95 ]. With respect to minerals, wholegrain is a good source of iron, magnesium, zinc, manganese, and selenium [ 72 ].…”

Section: Plausible Mechanisms By Which Wholegrains Might Protect Amentioning

confidence: 99%

Wholegrain Intake and Risk of Type 2 Diabetes: Evidence from Epidemiological and Intervention Studies

et al. 2018

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Type 2 diabetes mellitus (T2DM) is one of the most common metabolic diseases and represents a leading cause of morbidity and mortality because of its related complications. The alarming rise in T2DM prevalence worldwide poses enormous challenges in relation to its social, economic, and a clinical burden requiring appropriate preventive strategies. Currently, lifestyle modifications—including approaches to promote a moderate body weight reduction and to increase regular physical exercise—are the first crucial intervention for T2DM prevention. In the light of the difficulty in reducing body weight and in long-term maintenance of weight loss, quality changes in dietary patterns—in terms of macro and micronutrient composition—can also strongly affect the development of T2DM. This may provide a more practical and suitable preventative approach than simply implementing caloric restriction. Along this line, there is increasing evidence that wholegrain consumption in substitution of refined grains is associated with a reduction of the incidence of several non-communicable chronic diseases. The aim of the present review is to summarize the current evidence from observational and randomized controlled clinical trials on the benefits of wholegrain on T2DM prevention and treatment. Plausible mechanisms by which wholegrain could act on glucose homeostasis and T2DM prevention are also evaluated. Altogether, the totality of the available evidence supports present dietary recommendations promoting wholegrain foods for the prevention and treatment of T2DM.

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“…10 Some published literatures have suggested that elevated 8-iso-PGF 2α was associated with obesity and fat accumulation. 11,12 To better achieve the early prevention of obesityrelated diseases, further understanding on the relationship between adiposity and lipid peroxidation is necessary. Ohmori et al 13 found that the levels of plasma 8-iso-PGF 2α were significantly higher in the high BMI group.…”

Section: Introductionmentioning

confidence: 99%

“… 10 Some published literatures have suggested that elevated 8-iso-PGF 2α was associated with obesity and fat accumulation. 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

<p>Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China</p>

Wang

Cao

et al. 2020

DMSO

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Background: Obesity is reported to be associated with oxidative stress which can cause lipid peroxidation. However, the effects of gain in various weight-related anthropometric indices on lipid peroxidation remain unclear. We aimed to examine the cross-sectional and longitudinal associations between altered weight-related anthropometric indices and a marker of lipid peroxidation among urban adults in China. Methods: A total of 3762 participants from the Wuhan-Zhuhai cohort were included in the present study, with a follow-up of 3 years. Six weight-related anthropometric indicators were measured and calculated, including waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), a body shape index (ABSI), and body adiposity index (BAI). Individual urinary 8-iso-prostaglandin-F 2α (8-iso-PGF 2α) was determined via enzyme-linked immunosorbent assay to evaluate lipid peroxidation. We used generalized linear models to analyze the cross-sectional and longitudinal associations of weight-related anthropometric indices with a marker of lipid peroxidation and stratified analyses to estimate effect modification. Results: We found significant relationships between WHR, WHtR, ABSI, and urinary 8-iso-PGF 2α at baseline. Each 1% increase in WHR, WHtR, and ABSI was significantly associated with a 0.007, 0.004, and 0.104 increase in log-transformed 8-iso-PGF 2α concentration, respectively (P<0.05). In longitudinal analysis, positive dose-response relationships were observed between gains in BMI, BAI, and increased 8-iso-PGF 2α after adjusting for potential confounders (P trend <0.05). We also found that gender and smoking status modified the association of BMI gain and 8-iso-PGF 2α increment, and such an association was more obvious in female and non-smokers. Conclusion: Our research implied that gain in anthropometric indices may result in a higher level of lipid peroxidation.

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Urine 8-Isoprostane in Relation to Adiposity and Insulin Resistance in Individuals at High Cardiometabolic Risk

Abstract: Central obesity was independently associated with oxidative stress even in a population homogeneous for adiposity and cardiometabolic risk, whereas no relationship was observed between oxidative stress and insulin resistance.

Cited by 12 publications

References 25 publications

Potential roles of psychological and oxidative stress in insulin resistance: a cohort-based study

Potential roles of psychological and oxidative stress in insulin resistance: a cohort-based study

Wholegrain Intake and Risk of Type 2 Diabetes: Evidence from Epidemiological and Intervention Studies

<p>Associations of Gain in Weight-Related Anthropometric Indices with a Marker of Lipid Peroxidation: A Cohort Study Among Urban Adults in China</p>

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