A wheat biorefining strategy based on solid-state fermentation for fermentative production of succinic acid

Du, Chenyu; Lin, Sze Ki Carol; Koutinas, Apostolis; Wang, Ruohang; Dorado, Pilar; Webb, Colin

doi:10.1016/j.biortech.2008.03.019

Cited by 119 publications

(59 citation statements)

References 27 publications

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“…Current studies on SA production in batch and continuous reactors reflect that A.succinogenes is a competitive SA producer [13][14][15][16][17][18]. These studies report obtained yields and by-product distributions but do not attempt to reconcile the results with the central metabolic network by analysing the metabolic flux distribution.…”

Section: Introductionmentioning

confidence: 99%

Continuous succinic acid production by Actinobacillus succinogenes in a biofilm reactor: Steady-state metabolic flux variation

Bradfield

Nicol

2014

Biochemical Engineering Journal

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Continuous anaerobic fermentations were performed in a novel external-recycle, biofilm reactor using D-glucose and CO 2 as carbon substrates. Succinic acid (SA) yields were found to be an increasing function of glucose consumption with the succinic acid to acetic acid ratio increasing from 2.4 g g -1 at a glucose consumption of 10 g L -1 , to 5.7 g g -1 at a glucose consumption of 50 g L -1 . The formic acid to acetic acid ratio decreased from an equimolar value (0.77 g g -1 ) at a glucose consumption of 10 g L -1 to a value close to zero at 50 g L -1 .The highest SA yield on glucose and highest SA titre obtained were 0.91 g g -1 and 48.5 g L -1respectively. Metabolic flux analysis based on the established C 3 and C 4 metabolic pathways of Actinobacillus succinogenes revealed that the increase in the succinate to acetate ratio could not be attributed to the decrease in formic acid and that an additional source of NADH was present. The fraction of unaccounted NADH increased with glucose consumption, suggesting that additional reducing power is present in the medium or is provided by the activation of an alternative metabolic pathway. KeywordsFermentation, biofilms, bioreactors, succinic acid, metabolic flux analysis.Continuous succinic acid production by Actinobacillus succinogenes in a biofilm reactor: Steady-state metabolic flux variation 2

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Section: Introductionmentioning

confidence: 99%

Continuous succinic acid production by Actinobacillus succinogenes in a biofilm reactor: Steady-state metabolic flux variation

Bradfield

Nicol

2014

Biochemical Engineering Journal

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“…Specifically, the synthesis of xylanase, CMCase (a type of cellulase), α-amylase and exo-PG Xylanase production by A. awamori (a type of pectinase) by Aspergillus awamori was analyzed. We chose this microorganism because it had shown a very good performance in enzymes production by SSF on other substrates (11,21,33). In addition, a plate-type SSF bioreactor at lab scale was used in order to evaluate the effect of aeration on enzymes production.…”

Section: Introductionmentioning

confidence: 99%

Xylanase production by Aspergillus awamori under solid state fermentation conditions on tomato pomace

Umsza-Guez¹,

Díaz²,

Ory³

et al. 2011

Braz. J. Microbiol.

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“…The SSF process with enzyme extract carried out on a simple batch of babassu flour allowed 83% of the starch of the babassu flour to be converted into ethanol. Du et al [84] used wheat bran to synthetize protease and glucoamylase via SSF, which were utilized for flour and gluten hydrolysis. The hydrolysate was examined as generic feedstock for fermentative production of succinic acid and around 64 g/L succinic acid was obtained.…”

Section: Production Of Generic Fermentation Feedstock Mediummentioning

confidence: 99%

The Protagonism of Biocatalysis in Green Chemistry and Its Environmental Benefits

et al. 2017

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Abstract:The establishment of a bioeconomy era requires not only a change of production pattern, but also a deep modernization of the production processes through the implementation of novel methodologies in current industrial units, where waste materials and byproducts can be utilized as starting materials in the production of commodities such as biofuels and other high added value chemicals. The utilization of renewable raw resources and residues from the agro-industries, and their exploitation through various uses and applications through technologies, particularly solid-state fermentation (SSF), are the main focus of this review. The advocacy for biocatalysis in green chemistry and the environmental benefits of bioproduction are very clear, although this kind of industrial process is still an exception and not the rule. Potential and industrial products, such as biocatalysts, animal feed, fermentation medium, biofuels (biodiesel, lignocelulose ethanol, CH 4 , and H 2 ), pharmaceuticals and chemicals are dealt with in this paper. The focus is the utilization of renewable resources and the important role of enzymatic process to support a sustainable green chemical industry.

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A wheat biorefining strategy based on solid-state fermentation for fermentative production of succinic acid

Cited by 119 publications

References 27 publications

Continuous succinic acid production by Actinobacillus succinogenes in a biofilm reactor: Steady-state metabolic flux variation

Continuous succinic acid production by Actinobacillus succinogenes in a biofilm reactor: Steady-state metabolic flux variation

Xylanase production by Aspergillus awamori under solid state fermentation conditions on tomato pomace

The Protagonism of Biocatalysis in Green Chemistry and Its Environmental Benefits

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