A wearable lab-on-a-patch platform with stretchable nanostructured biosensor for non-invasive immunodetection of biomarker in sweat

Lee, Han‐Byeol; Meeseepong, Montri; Trung, Tran Quang; Kim, Bo‐Yeong; Lee, Nae‐Eung

doi:10.1016/j.bios.2020.112133

Cited by 111 publications

(81 citation statements)

References 63 publications

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“…The fundamental rule of biosensors in fighting against pandemic is proven in previous studies ( Lee et al, 2020 ; Morales-Narváez and Dincer, 2020 ; Zhu et al, 2020 ). As it is shown above, design and optimization of an effective, low cost and reliable detection system in a short period of time aimed for fighting pandemics can be possible with an accurate numerical simulation.…”

Section: Resultsmentioning

confidence: 66%

A computational simulation platform for designing real-time monitoring systems with application to COVID-19

Shahbazi

Jabbari

Esfahani

et al. 2021

Biosensors and Bioelectronics

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With the aim of contributing to the fight against the coronavirus disease 2019 (COVID-19), numerous strategies have been proposed. While developing an effective vaccine can take months up to years, detection of infected patients seems like one of the best ideas for controlling the situation. The role of biosensors in containing highly pathogenic viruses, saving lives and economy is evident. A new competitive numerical platform specifically for designing microfluidic-integrated biosensors is developed and presented in this work. Properties of the biosensor, sample, buffer fluid and even the microfluidic channel can be modified in this model. This feature provides the scientific community with the ability to design a specific biosensor for requested point-of-care (POC) applications. First, the validation of the presented numerical platform against experimental data and then results and discussion, highlighting the important role of the design parameters on the performance of the biosensor is presented. For the latter, the baseline case has been set on the previous studies on the biosensors suitable for SARS-CoV, which has the highest similarity to the 2019 nCoV. Subsequently, the effects of concentration of the targeted molecules in the sample, installation position and properties of the biosensor on its performance were investigated in 11 case studies. The presented numerical framework provides an insight into understanding of the virus reaction in the design process of the biosensor and enhances our preparation for any future outbreaks. Furthermore, the integration of biosensors with different devices for accelerating the process of defeating the pandemic is proposed.

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Section: Resultsmentioning

confidence: 66%

A computational simulation platform for designing real-time monitoring systems with application to COVID-19

Shahbazi

Jabbari

Esfahani

et al. 2021

Biosensors and Bioelectronics

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“…Recently, we reported an integrated wearable electrochemical biosensor patch for liquid handling and sweat cortisol detection which requires a complicated fabrication process. [9] Therefore, developing an immunobiosensor with a simple fabrication process, reduced number of steps in the measurement protocols (such as label-free and reagent-free), and integration with a microfluidic device to collect and store sweat is an emergent need to generate a wearable body-interfaced microfluidic-integrated immuno-biosensing patch for personal use.…”

Section: Introductionmentioning

confidence: 99%

Hollow Microfibers of Elastomeric Nanocomposites for Fully Stretchable and Highly Sensitive Microfluidic Immunobiosensor Patch

Huynh

Trung

Meeseepong

et al. 2020

Adv Funct Materials

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The on-body immunodetection of biomarkers in sweat would significantly augment the potential of wearable body-interfaced biosensors for self-testing but has been limited due to the difficulty of integrating liquid handling and immunobiosensing devices in a wearable platform. Herein, a stretchable microfluidic immunobiosensor (SMIB) patch with hollow microfibers of elastomeric nanocomposites for the highly sensitive on-body biosensing of neuropeptide Y (NPY), a stress biomarker, in human sweat is reported. The SMIB patch is composed of a stretchable liquid handling device and an electrochemical impedimetric immunobiosensor made of hollow and conductive microfibers of reduced graphene oxide (rGO) and rGO-Ag nanowires in polyurethane matrix, respectively. The patch possesses a low limit of detection of 50 fm, a large dynamic range (50 fm-1 nm), good linearity, no labeling or reagent requirements, and facile formation in a patch form factor. By combining handling of the biofluid and delivery of the washing solution by a simple finger-touch operation as well as the analytical capability of NPY with an extremely low concentration in human sweat, the SMIB patch is a promising approach toward wearable non-invasive immunodetection for self-testing.

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“…To move past rigid circuitry and electronics for wearable devices, many groups are opting to create soft, flexible sensors that can conform to the skin surface. A device developed by Lee et al (2020) used cortisol-specific MX210 antibodies immobilized on a gold nanostructured surface to fabricate the working electrode in their design. The high density of antibodies that they were able to achieve optimized the sensitivity of their design and created a lower limit of detection of 1 pg/mL and dynamic range of 1 pg/mL–1 μg/mL.…”

Section: Recent Developments In Stress Monitoring Systemsmentioning

confidence: 99%

“…The high density of antibodies that they were able to achieve optimized the sensitivity of their design and created a lower limit of detection of 1 pg/mL and dynamic range of 1 pg/mL–1 μg/mL. This working electrode was a part of a flexible, wearable lab-on-a-patch platform developed with polydimethylsiloxane that used microfluidic sweat collection with detection via redox mediator reagent reaction and faradaic electrochemical impedimetric spectroscopy, as shown in Figure 2B ; Lee et al (2020) . While using an antibody-antigen detection system is adequate, the sensor has the limitation of antibody-antigen instability and irreproducibility ( Schonbrunn, 2014 ).…”

Section: Recent Developments In Stress Monitoring Systemsmentioning

confidence: 99%

Stress Monitoring and Recent Advancements in Wearable Biosensors

Samson

Koh

2020

Front. Bioeng. Biotechnol.

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The stress response allows the body to overcome obstacles and prepare for threats, but sustained levels of stress can damage one’s health. Stress has long been measured through physical tests and questionnaires that rely primarily on user-inputted data, which can be subjective and inaccurate. To quantify the amount of stress that the body is experiencing biologically, analytical detection of biomarkers associated with the stress response recently have been developed. Novel stress sensing devices focus on cortisol sweat sensing as a part of wearable, flexible devices. These devices promise a real-time, continuous collection of stress data that can be used in clinical diagnoses or for personal stress monitoring and mediation.

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A wearable lab-on-a-patch platform with stretchable nanostructured biosensor for non-invasive immunodetection of biomarker in sweat

Cited by 111 publications

References 63 publications

A computational simulation platform for designing real-time monitoring systems with application to COVID-19

A computational simulation platform for designing real-time monitoring systems with application to COVID-19

Hollow Microfibers of Elastomeric Nanocomposites for Fully Stretchable and Highly Sensitive Microfluidic Immunobiosensor Patch

Stress Monitoring and Recent Advancements in Wearable Biosensors

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