A water-stable new luminescent Cd(Ⅱ) coordination polymer for rapid and luminescent/visible sensing of vanillin in infant formula

Chen, Yaxuan; Liu, Guocheng; Li, Xue; Wang, Xiuli

doi:10.1016/j.ica.2022.121051

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Regarding the analytical performance of our developed nanosensor, as shown in Table 5, when vanillin was measured using conventional fluorimetry, the sensitivity was excellent, with an LOD of 0.01. This LOD is 21-138 times more sensitive than previously reported fluorescence sensors [58][59][60], 16-23 times more sensitive than the previously reported electrochemical probes [61][62][63], and 14 times more sensitive than the recently reported chemiluminescence method [64] for vanillin determination. Regarding…”

Section: Comparison With Previously Reported Methods For Vanillin Det...mentioning

confidence: 54%

“…our developed smartphone-based assay of vanillin, it was 2.3-23 times more sensitive than the previously reported electrochemical, fluorimetric, and chemiluminescence methods for the determination of vanillin in food samples. Apart from sensitivity, the previously reported fluorimetric methods[58][59][60] used metal-based organic fluorophores that required sophisticated synthesis and are harmful to the environment. In addition, most of the reported electrochemical methods require laborious preparation of specially modified electrodes, limiting their widespread use.…”

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confidence: 99%

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Citrus/urea nitrogen‐doped carbon quantum dots as nanosensors for vanillin determination in infant formula and food products via factorial experimental design fluorimetry and smartphone

El Hamd,

El‐Maghrabey,

Almawash

et al. 2023

Luminescence

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Vanillin is a flavouring agent that is prohibited for use in infant food products with ages lower than 6 months. Excessive vanillin usage could lead to eating disorders, nausea, headache, and vomiting. Therefore, it is essential to control the contents of vanillin in food samples, especially in infant formula. Here, we developed a highly sensitive nanosensor for vanillin based on using green synthesized highly fluorescent (QY = 29.5%) N‐doped carbon quantum dots (N‐CQDs) as a turn‐off fluorescent nanoprobe. The N‐doped CQDs synthesis was adopted using citrus bulb squeeze extract and the commonly used fertilizer, urea, as substrates. After mixing with vanillin, the fluorescence of the N‐CQDs was largely quenched in a vanillin concentration‐dependent manner. The sensing conditions were optimized by quality‐by‐design using a two‐level full factorial design (22 FFD). The N‐doped CQDs could detect vanillin in the range 0.1–12.0 μg/ml with a limit of detection of 0.013 μg/ml. Next, a smartphone imaging‐based assay combined with a UV chamber was adopted and applied for vanillin determination. This simple detection technique showed sensitivity similar to that of the conventional fluorimetric method. Both conventional and smartphone‐based methods were successfully applied for the determination of vanillin in infant milk formula and biscuits and could detect real vanillin concentrations in the analyzed samples with high % recoveries (94.5% to 105.5%). At last, the biocompatibility of the newly synthesized N‐CQDs was tested, and it was found to be an excellent candidate for cancer cell imaging.

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Section: Comparison With Previously Reported Methods For Vanillin Det...mentioning

confidence: 54%

mentioning

confidence: 99%

Citrus/urea nitrogen‐doped carbon quantum dots as nanosensors for vanillin determination in infant formula and food products via factorial experimental design fluorimetry and smartphone

El Hamd,

El‐Maghrabey,

Almawash

et al. 2023

Luminescence

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Self-ratiometric fluorescence approach based on plant extract-assisted synthesized silver nanoparticles for the determination of vanillin

El Hamd,

El-Maghrabey,

Almawash

et al. 2023

Microchim Acta

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Manganese cobalt sulfide nanoparticles wrapped by reduced graphene oxide: a fascinating nanocomposite as an efficient electrochemical sensing platform for vanillin determination

Deng,

Zhou,

Sun

et al. 2025

Journal of Future Foods

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A water-stable new luminescent Cd(Ⅱ) coordination polymer for rapid and luminescent/visible sensing of vanillin in infant formula

Cited by 3 publications

References 46 publications

Citrus/urea nitrogen‐doped carbon quantum dots as nanosensors for vanillin determination in infant formula and food products via factorial experimental design fluorimetry and smartphone

Citrus/urea nitrogen‐doped carbon quantum dots as nanosensors for vanillin determination in infant formula and food products via factorial experimental design fluorimetry and smartphone

Self-ratiometric fluorescence approach based on plant extract-assisted synthesized silver nanoparticles for the determination of vanillin

Manganese cobalt sulfide nanoparticles wrapped by reduced graphene oxide: a fascinating nanocomposite as an efficient electrochemical sensing platform for vanillin determination

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