A Visible‐ and NIR‐Light Responsive Photothermal Therapy Agent by Chirality‐Dependent MoO3−x Nanoparticles

Li, Yiwen; Miao, Ziwei; Shang, Zhengwen; Cai, Ying; Cheng, Jiaji; Xu, Xiaoqian

doi:10.1002/adfm.201906311

Cited by 88 publications

(66 citation statements)

References 33 publications

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“…[38,39] Thus, the MoO 3-x nanomaterials were applied in photothermal removal of cancer. [40][41][42] The convenient way to obtain MoO 3-x nanomaterials is to separate from bulk oxide [17] MoO 3 powders with an exfoliation process, which is time consuming and low yield. Generally, the extraction of MoO 3-x nanoparticles can be classified as two categories: hydrothermal and chemical exfoliation.…”

Section: Introdutionmentioning

confidence: 99%

Morphology‐controlled Synthesis of Molybdenum Oxide with Tunable Plasmon Absorption for Phothermal Therapy of Cancer

Zhang

Guo

et al. 2020

ChemNanoMat

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Semiconductor nanocrystals showing surface plasmonic absorption features can be used as prospective substitutes for noble metallic nanoparticles. Herein, a creative one‐pot hydrothermal route without template is used to synthesize plasmonic oxygen deficiency molybdenum oxide (MoO3‐x) nanoparticles. The morphologies of as‐prepared MoO3‐x nanomaterials arranged from amorphous to crystalline with the reaction temperature varied from 160 °C, 180 °C to 200 °C, namely MoO3‐x quantum dots (QDs), MoO3‐x nanosheets, and MoO2 nanospheres. Simultaneously, in the near‐infrared region (NIR), MoO3‐x nanomaterials exhibit gradually enhanced localized surface plasmon resonance (LSPR) absorption, of which MoO2 nanospheres exhibit intense NIR absorption with a photothermal conversion efficiency up to 72.5% under 808 nm NIR laser irradiation. Moreover, the toxicity and cancer therapy efficacy of MoO2 nanospheres have been systematically assessed in vitro and in vivo, respectively. The results revealed that MoO2 nanospheres exhibit low toxicity and high therapeutic efficiency, making it an promising and effective photothermal agent in photothermal therapy

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Section: Introdutionmentioning

confidence: 99%

Morphology‐controlled Synthesis of Molybdenum Oxide with Tunable Plasmon Absorption for Phothermal Therapy of Cancer

Zhang

Guo

et al. 2020

ChemNanoMat

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“…As reported previously, the phase structure and valence state of molybdenum oxides were considered as two main factors that affect their photothermal properties [46,47]. In the present work, to understand the mechanism of enhanced photothermal effects, the effects of Mo resource dosage and reduction temperature on the photothermal properties of MoO 3−x @PPSNs were explored.…”

Section: Photothermal Properties Measurementmentioning

confidence: 79%

Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

et al. 2021

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Molybdenum oxide nanoparticles (NPs) with tunable plasmonic resonance in the near-infrared region display superior semiconducting features and photothermal properties, which are highly related to the crystalline and defective structures such as oxygen deficiencies. However, fundamental understanding on the structure-function relationship between crystalline/defective structures and photothermal properties is still unclear. To address this, herein, we have developed an "in-situ confined oxidation-reduction" strategy to regulate the defect features of molybdenum oxide NPs in the dual-mesoporous silica nanoreactor. Especially, the effects of crystalline structure/oxygen defects of molybdenum oxides on the photothermal performances were investigated by facilely tuning the amount of molybdenum resource and the reduction temperature. As a photothermal nanoagent, the optimal defective molybdenum oxide NPs encapsulated in PEGylated porous silica nanoreactor (designated as MoO 3−x @PPSNs) exhibit excellent biological stability and strong localized surface plasmon resonance effect in nearinfrared absorption range with the highest photothermal conversion efficiency up to 78.7% under 808 nm laser irradiation. More importantly, the remarkable photothermal effects of MoO 3−x @PPSNs were comprehensively demonstrated both in vitro and in vivo. Consequently, we envision that the plasmonic MoO 3−x NPs in a biocompatible porous silica nanoreactor could be used as an efficient photothermal therapy agent for photothermal ablation of tumors.

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“…In addition, Kotov “and co‐workers [ 45 ] as mentioned in Figure 3B exhibited that nonstoichiometric WO 3− x NPs are capable for peptide catalysis. 3)Chiral nanophotonics: Deng and co‐workers [ 59 ] have highlighted that CuO/cellulose crystal (CNC) and CuO (calcinated from CuO/CNC) nanoflowers can both serves as chiral template for generating full‐color CPL when achiral fluorescent dyes are mixed with them (Figure 4C). Besides, Kotov's recent work, [ 44 ] as shown in Figure 3A, pointed out that chiral Co 3 O 4 gels can realize optical modulation via a magnetic field leading to strong absorption variation. 4)Chirality‐based therapy: Our work on nonstoichiometric chiral MoO 3− x NPs [ 60 ] showed both visible‐ and NIR‐light selective absorption due to the chirality induction by surface chiral ligands, which enables chiral MoO 3− x NPs as dual‐mode photothermal therapy (PTT) agents for cancer treatments (Figure 4D). Similarly, Kuang's work [ 2 ] as previously discussed, showed that phenylalanine‐capped Cu x O NPs can be used to scavenge ROS in vivo, therefore rescued the memory loss of mice with Parkinson's disease. 5)Chirality‐based devices: As mentioned in Figure 2D, the layer‐by‐layer nanostructure of chiral NiMoO 4 · x H 2 O photonic crystals reported by Tang and co‐workers [ 37 ] exhibited extremely large chiroptical activity ( g max ≈ −1.6) with tunable features providing possibilities for chirality‐based multifunctional devices with favorable optical, electrical, and magnetic properties.…”

Section: Applications and Perspectivesmentioning

confidence: 93%

“…Besides, Kotov's recent work, [44] as shown in Figure 3A, pointed out that chiral Co 3 O 4 gels can realize optical modulation via a magnetic field leading to strong absorption variation. 4) Chirality-based therapy: Our work on nonstoichiometric chiral MoO 3−x NPs [60] showed both visible-and NIR-light selective absorption due to the chirality induction by surface chiral ligands, which enables chiral MoO 3−x NPs as dual-mode photothermal therapy (PTT) agents for cancer treatments ( Figure 4D). Similarly, Kuang's work [2] as previously discussed, showed that phenylalanine-capped Cu x O NPs can be Reproduced with permission.…”

Section: Applications and Perspectivesmentioning

confidence: 99%

Chiral Transition Metal Oxides: Synthesis, Chiral Origins, and Perspectives

Wang

Miao³

et al. 2020

Advanced Materials

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to inorganic nanocrystals (NCs) whose unique physicochemical properties could be easily tuned by altering their size, shape, or ingredient, providing a powerful platform for exploring enhanced chiroptical effects, chirogenesis, and potentials in which chiral inorganic NCs could provide to interdisciplinary fields such as optical and biosensing, [2,3] chiral bioimaging, [4] and polarization-based display devices. [5] In general, chirality in inorganic NCs can be obtained from: [6,7] 1) intrinsic chirality formed by chiral crystals, lattice distortions, and defects, [8-10] 2) chiral shape with subwavelength dimensions, [11] 3) chirality transfer via chiral assembled nanostructures of achiral NCs, [5,12] and 4) chiral interactions of achiral NCs with chiral molecules [13] as depicted in Figure 1. The most famous property of chiral nanostructure is the optical activity which refers to the ability of a chiral unit to rotate the plane of plane polarized light. [14] In modern optics, this property is associated to the circular dichroism (CD) phenomenon, which concerns the absorption difference between left and right circularly polarized (LCP and RCP) light, therefore CD-based spectroscopies are generally regarded as powerful tools to detect chirality of a measured sample. With rapid development, a number of cutting-edge work concerning on chiral metal nanoparticles (NPs), chiral semiconductor NCs, chiral ceramics, and metal coordinate systems has been investigated recently. [6] Among them, chiral transition metal oxides (TMOs) are a newly discovered area attracting tremendous attentions because of their striking feature for nonstoichiometry even though great challenges on establishing systematic control over the synthesis and theoretical supports for chirality induction mechanisms still remain. Since the nature of metal-oxygen bonding in TMOs can vary from nearly ionic to covalent or metallic, the physicochemical properties of TMOs are strongly related to their outer d electrons. [15] When combined with chiral molecules, the overlap of the orbital of chiral molecules with the density of states of TMOs or formation of chiral surfaces can bring in tunable chirality for TMOs from UV-visible to near infrared region, endowing fascinating chiroptical properties. Therefore, herein, we emphasize recent progress on chiral TMOs in terms of their synthesis, CD effects, and possible mechanisms of induced optical chirality. In Section 2, theoretical background on the origin of induced chirality in TMOs nanostructures is briefly introduced. Section 3 will show recent progress of chiral TMOs with their synthetic Transition metal oxides (TMOs) consist of a series of solid materials, exhibiting a wide variety of structures with tunability and versatile physicochemical properties. Such a statement is undeniably true for chiral TMOs since the introduction of chirality brings in not only active optical activities but also geometrical anisotropy due to the symmetry-breaking effect. Although progressive investigations have been made for accu...

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A Visible‐ and NIR‐Light Responsive Photothermal Therapy Agent by Chirality‐Dependent MoO₃₋_x Nanoparticles

Cited by 88 publications

References 33 publications

Morphology‐controlled Synthesis of Molybdenum Oxide with Tunable Plasmon Absorption for Phothermal Therapy of Cancer

Morphology‐controlled Synthesis of Molybdenum Oxide with Tunable Plasmon Absorption for Phothermal Therapy of Cancer

Confined structure regulations of molybdenum oxides for efficient tumor photothermal therapy

Chiral Transition Metal Oxides: Synthesis, Chiral Origins, and Perspectives

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