A Viscoelastic Biomechanical Model of the Cornea Describing the Effect of Viscosity and Elasticity on Hysteresis

Glass, D. H.; Roberts, Cynthia J.; Litsky, Alan S.; Weber, Paul A.

doi:10.1167/iovs.07-1321

Cited by 176 publications

(151 citation statements)

References 28 publications

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“…In this concave state, tear film tension pulls the cornea back toward applanation. 22 The reflection of the infrared light gives indirect evidence that the tear film remains intact in healthy eyes. In this current study we performed ORA measurements on dry-eye patients, but we did not see any difference in the reflection of the infrared light between dry eye and normal subjects.…”

Section: Discussionmentioning

confidence: 99%

Corneal hysteresis in patients with dry eye

Fırat

Doğanay

2011

Eye

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Section: Discussionmentioning

confidence: 99%

Corneal hysteresis in patients with dry eye

Fırat

Doğanay

2011

Eye

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“…[26][27][28][29][30] Compared with the number of experimental studies, there is less theoretical work in these aspects. Glass et al 31 developed a simplified model to evaluate the corneal viscosity and elasticity in response to an air puff, but neither the nonlinearity of the corneal elastic properties nor the effect of corneal mass were taken into consideration. Elsheikh et al 32 used finite element analysis to simulate the corneal response as a function of thickness, curvature, age, and true IOP.…”

Section: Discussionmentioning

confidence: 99%

Air Puff Induced Corneal Vibrations: Theoretical Simulations and Clinical Observations

Han¹,

Chen²,

Zhou³

et al. 2014

J Refract Surg

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PURPOSE: To investigate air puff induced corneal vibrations and their relationship to the intraocular pressure (IOP), viscoelasticity, mass, and elasticity of the cornea based on theoretical simulations and preliminary clinical observations. METHODS:To simulate the corneal movement during air puff deformation, a kinematic viscoelastic corneal model was developed involving the factors of corneal mass, damping coefficient, elasticity, and IOP. Different parameter values were taken to investigate how factors would affect the corneal movements. Two clinical ocular instruments, CorVis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) and the Ocular Response Analyzer (ORA; Reichert, Inc., Buffalo, NY), were employed to observe the corneal dynamical behaviors. RESULTS:Numerical results showed that during the air puff deformation, there would be vibrations along with the corneal deformation, and the damping viscoelastic response of the cornea had the potential to reduce the vibration amplitude. With consistent IOP, the overall vibration amplitude and inward motion depths were smaller with a stiffer cornea.CONCLUSIONS: A kinematic viscoelastic model of the cornea is presented to illustrate how the vibrations are associated with factors such as corneal mass, viscoelasticity, and IOP. Also, the predicted corneal vibrations during air puff deformation were confirmed by clinical observation.[J Refract Surg. 2014;30(3):208-213.]

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“…They have shown that the cornea has nonlinear viscoelastic behaviour over a large range of pressures (Boyce et al 2007, Glass et al 2008. Nguyen et al have developed a complete nonlinear viscoelastic rheological model for the cornea that considers its anisotropy ).…”

Section: Introductionmentioning

confidence: 99%

A hybrid approach to determining cornea mechanical properties in vivo using a combination of nano-indentation and inverse finite element analysis

Abyaneh

Wildman

Ashcroft

et al. 2013

Journal of the Mechanical Behavior of Biomedical Materials

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A hybrid approach to determining cornea mechanical properties in vivo using a combination of nano-indentation and inverse finite element analysis approach. A validation experiment using nano-indentation showed that an isotropic GM model was insufficient for describing the corneal material behaviour when exposed to a complex stress state. A new technique was proposed for determining the properties, using a combination of nano-indentation experiment, an isotropic and orthotropic GM model and inverse finite element method. The good agreement using this method suggests that this is a promising technique for measuring material properties in vivo and further work should focus on the reliability of the approach in

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A Viscoelastic Biomechanical Model of the Cornea Describing the Effect of Viscosity and Elasticity on Hysteresis

Abstract: A viscoelastic model is presented to illustrate how changing viscosity and elasticity may affect hysteresis. Low hysteresis can be associated with either high elasticity or low elasticity, depending on the viscosity, a finding consistent with clinical reports.

Cited by 176 publications

References 28 publications

Corneal hysteresis in patients with dry eye

Corneal hysteresis in patients with dry eye

Air Puff Induced Corneal Vibrations: Theoretical Simulations and Clinical Observations

A hybrid approach to determining cornea mechanical properties in vivo using a combination of nano-indentation and inverse finite element analysis

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