Corneal hysteresis in patients with dry eye

Fırat, Penpe Gül; Doğanay, Selim

doi:10.1038/eye.2011.211

Cited by 19 publications

(14 citation statements)

References 19 publications

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“…Conflicting results are available in the literature regarding central corneal thickness in DED. Although few studies showed similar values between DED patients and normal subjects[24–27], we found significantly lower values in patients with oGVHD compared to controls, in agreement with others. [32–34] The corneal thinning in DED is attributed to the increased osmolarity of the tear film that induces the activation of the inflammatory cascade and stimulate the production of high levels of the cytokine and MMP-9 by the distressed epithelial cells.…”

Section: Discussionsupporting

confidence: 92%

“…CorVis ST is a device that employs an ultrahigh speed Scheimpflug camera to record dynamic deformation of the cornea. Impaired values of corneal biomechanics have been reported in DED patients with and without Sjögren’s syndrome[24–26]; conversely, Firat et al[27] reported no alterations of corneal biomechanical parameters in patients with DED. However, this study did not evaluate comprehensively ocular surface parameters, and did not stratify patients according to the severity of DED.…”

Section: Discussionmentioning

confidence: 99%

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Corneal Biomechanical Alterations in Patients with Chronic Ocular Graft Versus-host Disease

Giannaccare

Pellegrini

Taroni

et al. 2019

Preprint

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22Purpose: To compare corneal biomechanics between patients with ocular graft versus-host 23 disease (oGVHD) and healthy subjects (controls), and to further correlate these values with 24 ocular and hematological characteristics. 25 Materials and Methods: The following procedures were performed in oGVHD patients and 26 controls: Schirmer test (ST), break-up time (BUT), corneal and conjunctival staining, tear 27 matrix metalloproteinase-9 (MMP-9) assay (InflammaDry test, Rapid Pathogen Screening, 28 Inc, Sarasota, FL). Corneal biomechanics were calculated by using ocular response analyzer 29 (ORA, Reichert Instruments, Depew, New York, USA). The Mann-Whitney U test was used 30 to compare continuous variables between oGVHD patients and controls. Correlations of 31 corneal biomechanics with ocular and hematological parameters were examined using 32Spearman's correlation. 33Results: A total of 45 oGVHD patients (mean age ± SD, 51.5 ± 7.1 years) and 34 controls 34 (47.8 ± 6.1 years) were included. Patients with oGVHD showed significantly lower values of 35 corneal hysteresis (CH) and corneal resistance factor (CRF) compared to controls 36 (respectively, 9.4 ± 1.8 mmHg vs 11.6 ± 1.6 and 9.7 ± 1.4 mmHg vs 12.3 ± 1.3; always 37 p<0.001). Twenty-nine of the oGVHD eyes (64.4%) were strong-positive for MMP-9, while 38 16 (35.6%) were weak-positive. Conversely, only 4 of the control eyes (11.8%) were weak-39 positive for MMP-9. In patients with oGVHD, CH was significantly correlated with corneal 40 staining (Rs = -0.316, p = 0.035), conjunctival staining (Rs = -0.437, p = 0.003), ST (Rs = 41 0.390, p = 0.008), BUT (Rs = 0.423, p = 0.004), oGVHD severity grade (Rs = -0.383, p = 42 0.009), and MMP-9 positivity grade (Rs = -0.429, p = 0.003), while CRF was correlated only 43 with corneal staining (Rs = -0.317, p = 0.034). 44Conclusions: Corneal biomechanics are reduced in patients with oGVHD, and CH is 45 negatively correlated with disease severity grade and MMP-9 tear levels. 46 47 51 Allogeneic hematopoietic stem cell transplantation (HSCT) is an established and potentially 52 curative treatment for a variety of malignant and non-malignant hematological disorders. 53 Graft versus-host disease (GVHD) is a multi-organ systemic disease caused by complex 54 interactions between donor and recipient immune systems and represents the leading cause of 55 morbidity following HSCT.[1] Chronic ocular GVHD (oGVHD) develops in 40 to 60% of 56 patients undergoing HSCT, and dry eye disease (DED) represents the hallmark of this 57 condition.[2-4] The disease is thought to be the result of the progressive immune-mediate 58 inflammatory damage of ocular surface structures, which may lead to lacrimal and meibomian 59 glands dysfunction, conjunctival keratinization, corneal epitheliopathy, eyelid laxity and 60 scarring, and in more severe cases even corneal melting and perforation.[5-7] 61 Recent proteomic studies evaluated the various constituent compositions of tears 62 inflammatory mediators in eyes with oGVHD and detected increased levels of...

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Corneal Biomechanical Alterations in Patients with Chronic Ocular Graft Versus-host Disease

Giannaccare

Pellegrini

Taroni

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Fraunfelder reported corneal problems, such as keratitis, corneal opacity, corneal ulceration, and keratoconus, as the second most prevalent adverse effect among patients during isotretinoin treatment [ 21 ]. Firat and Doganay conducted a study in patients with dry eye and concluded that CH and CRF are not influenced by dry eye [ 22 ]. We would like to investigate whether the changes in precorneal tear film properties induced by isotretinoin have an effect on the corneal biomechanics measured with ORA.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Corneal Topography and Biomechanical Parameters after Use of Systemic Isotretinoin in Acne Vulgaris

Yıldırım

Olcucu

Ağca

et al. 2014

Journal of Ophthalmology

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Purpose. We report the effect of isotretinoin on corneal topography, corneal thickness, and biomechanical parameters in patients with acne vulgaris. Method. Fifty-four eyes of 54 patients who received oral isotretinoin for treatment of acne vulgaris were evaluated. All patients underwent a corneal topographical evaluation with a Scheimpflug camera combined with Placido-disk (Sirius), ultrasonic pachymetry measurements, and corneal biomechanical evaluation with an ocular response analyzer at baseline, in the 1st, 3rd, and 6th months of treatment, and 6 months after isotretinoin discontinuation. Results. The thinnest corneal thickness measured with Sirius differed significantly in the 1st, 3rd, and 6th months compared with the baseline measurement; there was no significant change in ultrasonic central corneal thickness measurements and biomechanical parameters (corneal hysteresis and corneal resistance factor) throughout the study. Average simulated keratometry and surface asymmetry index increased significantly only in the first month of treatment according to the baseline. All changes disappeared 6 months after the end of treatment. Conclusion. Basal tear secretion and corneal morphologic properties were significantly influenced during the systemic isotretinoin treatment and the changes were reversible after discontinuation. No statistical important biomechanical differences were found to be induced by isotretinoin.

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“…Although there is a study show that dry eye does not affect biomechanical measurements with ORA. 27 The second limitation of this study is the absence of assessment of dry eye test results when comparing groups. In further studies the effect of dry eye could be taken into consideration to more properly interpret the results.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Duration of Disease on Corneal Biomechanical Properties in Patients with Rheumatoid Arthritis

Anayol¹,

Tirhiş²,

Doğan³

et al. 2017

Turkiye Klinikleri J Ophthalmol

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Corneal hysteresis in patients with dry eye

Abstract: Purpose To measure corneal hysteresis and intraocular pressure (IOP)

Cited by 19 publications

References 19 publications

Corneal Biomechanical Alterations in Patients with Chronic Ocular Graft Versus-host Disease

Corneal Biomechanical Alterations in Patients with Chronic Ocular Graft Versus-host Disease

Evaluation of Corneal Topography and Biomechanical Parameters after Use of Systemic Isotretinoin in Acne Vulgaris

The Effect of Duration of Disease on Corneal Biomechanical Properties in Patients with Rheumatoid Arthritis

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