A Virus Disease of Swiss Mice Transmissible by Intranasal Inoculation

Dochez, A. R.; Mills, K. C.; Mulliken, Barbara

doi:10.3181/00379727-36-9357

Cited by 35 publications

(10 citation statements)

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“…These latter agents were readily encountered in rapid (4 to 5 day) serial mouse passages, whereas the virus described herein was recoverable only when slow (7 to 9 day) serial mouse passages were made. Furthermore, the course of the disease was relatively rapid with those viruses which have been described by other investigators (5,6) and mice usually died in 2 to 4 days. The virus described in this communication seldom killed mice before the 8th day after inoculation irrespective of the quantity of virus given.…”

Section: Discussionmentioning

confidence: 69%

“…Our virus, on the other hand, was entirely non-infectious for ferrets and did not become infectious for this species even after a number of serial ferret passages. Most significant, perhaps, as evidence of the differences is the fact that those viruses described by previous investigators (5,6) were either non-antigenic or were very poor antigens and failed to immunize mice against themselves. They also failed to produce neutralizing antisera after injection into rabbits.…”

Section: Discussionmentioning

confidence: 97%

“…I t is the purpose of this paper to report the isolation of a number of strains of a pneumotropic virus from normal mouse lungs and to present the results of studies designed to determine some of its characteristics. Evidence that this virus is different from the viruses which have been found in normal mouse lungs b y other investigators (5,6) will be given.…”

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confidence: 84%

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A Latent Virus in Normal Mice Capable of Producing Pneumonia in Its Natural Host

Horsfall

Hahn

1940

Journal of Experimental Medicine

104

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1. A virus capable of producing fatal pneumonia in mice has been isolated repeatedly from the lungs of certain apparently healthy mice. Not all mice carry the virus. It was obtained only from mice supplied by three breeders although mice from eight different sources were studied. 2. The virus was avirulent as it occurred in normal mouse lungs and became virulent only after serial mouse lung passage. It was strictly pneumotropic for mice and produced pneumonia when given intranasally but showed no evidence of infection when given by other routes. The virus was non-infectious for ferrets and did not become pathogenic for this species after numerous serial passages. It was also non-pathogenic for rabbits, guinea pigs, rhesus monkeys, voles, deer mice, skunks, wood-chucks, opossums, and Syrian hamsters. 3. All strains of the virus which have been tested have been immunologically identical, as indicated both by cross immunity and cross neutralization tests in mice. 4. The virus was antigenic both in mice and in rabbits and was readily differentiated from viruses of human influenza and of swine influenza by means of either cross immunity or cross neutralization tests. 5. The virus was also neutralized by about 30 per cent of normal human sera tested. 6. The virus was extremely labile, and suspensions prepared in saline or broth became inactivated within a few hours at room temperature. The addition of normal horse serum to the virus suspensions, however, exerted a definite stabilizing effect. 7. Ultrafiltration results indicated that the virus particles have a diameter of about 100 to 150 millimicrons. 8. Evidence is presented which indicates that this virus is different from other viruses which various investigators have found in normal mouse lungs.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 97%

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A Latent Virus in Normal Mice Capable of Producing Pneumonia in Its Natural Host

Horsfall

Hahn

1940

Journal of Experimental Medicine

104

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“…A similar story has to be told now that passage of viruses by intranasal inoculation of miee has become a popular technique. Dochez et al (1937), Gordon, Freeman and Clampit (1938), and Horsfall and Hahn (1939), have thus brought to light viruses caiusing pneumonia in mice. The agents described by these authors are not necessarily the same, but in each instance some material or other has been clropped up the noses of nice, their lungs have been later harvested and emulsions thereof dropped up the noses of other mice.…”

Section: Indigenous Viruses Of Animalsmentioning

confidence: 99%

Latent Virus Infections and Their Possible Relevance to the Cancer Problem

Andrewes¹

1939

Proceedings of the Royal Society of Medicine

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“…While C. trachomatis infects humans, closely related C. muridarum naturally occurs in members of the family Muridae, producing a subclinical respiratory infection in young laboratory albino Swiss mice (Nigg and Eaton 1944). Infection by C. muridarum (MoPn) in laboratory mice was first observed by Dochez et al (1937). Because all oculo-genital strains of C.…”

Section: Introductionmentioning

confidence: 99%

Chlamydiaceae and Chlamydia-Like Organisms in Free-Living Small Mammals in Europe and Afghanistan

Stephan

Pospischil

Hilbe

et al. 2014

Journal of Wildlife Diseases

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ABSTRACT:Few data are available on the occurrence of chlamydial infections in wild small mammals. We investigated the significance of free-living small mammals as reservoirs or transmission hosts for microorganisms of the phylum/class Chlamydiae. We obtained 3,664 tissue samples from 911 animals in Switzerland, Germany, Austria, the Czech Republic, and Afghanistan. Samples included internal organs (n53,652) and feces (n512) from 679 rodents (order Rodentia) and 232 insectivores (order Soricomorpha) and were tested by three TaqManH real-time PCRs specific for members of the family Chlamydiaceae and selected Chlamydia-like organisms such as Parachlamydia spp. and Waddlia spp. Only one of 911 (0.11%) animals exhibited a questionable positive result by Chlamydiaceae-specific real-time PCR. Five of 911 animals were positive by specific real-time PCR for Parachlamydia spp. but could not be confirmed by quantitative PCR targeting the Parachlamydia acanthamoebae secY gene (secY qPCR). One of 746 animals (0.13%) was positive by real-time PCR for Waddlia chondrophila. This result was confirmed by Waddlia secY qPCR. This is the first detection of Chlamydia-like organisms in small wildlife in Switzerland. Considering previous negative results for Chlamydiaceae in wild ruminant species from Switzerland, these data suggest that wild small mammals are unlikely to be important carriers or transport hosts for Chamydiaceae and Chlamydia-like organisms.

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A Virus Disease of Swiss Mice Transmissible by Intranasal Inoculation

Cited by 35 publications

References 0 publications

A Latent Virus in Normal Mice Capable of Producing Pneumonia in Its Natural Host

A Latent Virus in Normal Mice Capable of Producing Pneumonia in Its Natural Host

Latent Virus Infections and Their Possible Relevance to the Cancer Problem

Chlamydiaceae and Chlamydia-Like Organisms in Free-Living Small Mammals in Europe and Afghanistan

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