A versatile chitosan nanogel capable of generating AgNPs in-situ and long-acting slow-release of Ag+ for highly efficient antibacterial

Fan, Mengni; Si, Jianxiao; Xu, Xiaogang; Chen, Linfu; Chen, Junpeng; Yang, Chao; Zhu, Jingwu; Wu, Lihuang; Tian, Jiang; Chen, Xiaoyi; Mou, Xiaozhou; Cai, Xiaojun

doi:10.1016/j.carbpol.2021.117636

Cited by 44 publications

(47 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was proved using the CFU counting method for both bacteria species and for both times analyses, that the survival of microorganisms decreases while the incubation time and the concentration of composites are increasing for short-term analysis. Moreover, the study confirms the differences observed in other studies described between Gram-negative and Gram-positive species, since the effect on E. Coli was obtained faster and in lower concentrations (150 μg/mL in 90 min) comparing to S. aureus , where even at a double concentration, their action was delayed (300 μg/mL in 210 min) [ 67 ].…”

Section: Silver Nanoparticles—overview and Synthesis Methodssupporting

confidence: 89%

“…However, in all medical applications, their activity remains the same, assuring an antibacterial activity for possible infections. A novel nanogel based on chitosan was developed by Fan et al [ 67 ] to ensure the slow-release of Ag and to prevent possible damages to surrounding tissues. Using the electrostatic interactions between sulfonated chitosan and chitosan/Ag NPs, nanogels with Ag + absorbed were obtained.…”

Section: Silver Nanoparticles—overview and Synthesis Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Ag Nanoparticles for Biomedical Applications—Synthesis and Characterization—A Review

Nicolae-Maranciuc

Chicea

2022

IJMS

View full text Add to dashboard Cite

Silver nanoparticles have been intensively studied over a long period of time because they exhibit antibacterial properties in infection treatments, wound healing, or drug delivery systems. The advantages that silver nanoparticles offer regarding the functionalization confer prolonged stability and make them suitable for biomedical applications. Apart from functionalization, silver nanoparticles exhibit various shapes and sizes depending on the conditions used through their fabrications and depending on their final purpose. This paper presents a review of silver nanoparticles with respect to synthesis procedures, including the polluting green synthesis. Currently, the most commonly used characterization techniques required for nanoparticles investigation in antibacterial treatments are described briefly, since silver nanoparticles possess differences in their structure or morphology.

show abstract

Section: Silver Nanoparticles—overview and Synthesis Methodssupporting

confidence: 89%

Section: Silver Nanoparticles—overview and Synthesis Methodsmentioning

confidence: 99%

Ag Nanoparticles for Biomedical Applications—Synthesis and Characterization—A Review

Nicolae-Maranciuc

Chicea

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Research on the development of antimicrobial and hemostatic materials is gaining prominence. For example, studies have demonstrated the use of silver (Ag) ions as a broad-spectrum antimicrobial agent [ [12] , [13] , [14] ] that can inhibit the growth of fungi, gram-positive bacteria, gram-negative bacteria, and viruses, and these have since become common in biomedical applications. Ong et al.…”

Section: Introductionmentioning

confidence: 99%

Construction of multifunctional porcine acellular dermal matrix hydrogel blended with vancomycin for hemorrhage control, antibacterial action, and tissue repair in infected trauma wounds

Cai

Chen

et al. 2021

Materials Today Bio

View full text Add to dashboard Cite

Prevention of bacterial infection and reduction of hemorrhage, the primary challenges posed by trauma before hospitalization, are essential steps in prolonging the patient's life until they have been transported to a trauma center. Extracellular matrix (ECM) hydrogel is a promising biocompatible material for accelerating wound closure. However, due to the lack of antibacterial properties, this hydrogel is difficult to be applied to acute contaminated wounds. This study formulates an injectable dermal extracellular matrix hydrogel (porcine acellular dermal matrix (ADM)) as a scaffold for skin defect repair. The hydrogel combines vancomycin, an antimicrobial agent for inducing hemostasis, expediting antimicrobial activity, and promoting tissue repair. The hydrogel possesses a porous structure beneficial for the adsorption of vancomycin. The antimicrobial agent can be timely released from the hydrogel within an hour, which is less than the time taken by bacteria to infest an injury, with a cumulative release rate of approximately 80%, and thus enables a relatively fast bactericidal effect. The cytotoxicity investigation demonstrates the biocompatibility of the ADM hydrogel. Dynamic coagulation experiments reveal accelerated blood coagulation by the hydrogel. In vivo antibacterial and hemostatic experiments on a rat model indicate the healing of infected tissue and effective control of hemorrhaging by the hydrogel. Therefore, the vancomycin-loaded ADM hydrogel will be a viable biomaterial for controlling hemorrhage and preventing bacterial infections in trauma patients.

show abstract

“…ICP-MS was used to assess the Ag doping rate, 26 – 28 , which reached a maximum of ~38.43% when the AgNO 3 feeding concentration was increased to 10 mg mL −1 (Fig. 1g ).…”

Section: Resultsmentioning

confidence: 99%

POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

Cao

Zhang

Yang

et al. 2022

Sig Transduct Target Ther

View full text Add to dashboard Cite

The current feasibility of nanocatalysts in clinical anti-infection therapy, especially for drug-resistant bacteria infection is extremely restrained because of the insufficient reactive oxygen generation. Herein, a novel Ag/Bi2MoO6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized by solvothermal reaction and photoreduction. The Ag/BMO nanozyme held satisfactory bactericidal performance against methicillin-resistant Staphylococcus aureus (MRSA) (~99.9%). The excellent antibacterial performance of Ag/BMO NPs was ascribed to the corporation of peroxidase-like activity, NIR-II photodynamic behavior, and acidity-enhanced release of Ag+. As revealed by theoretical calculations, the introduction of Ag to BMO made it easier to separate photo-triggered electron-hole pairs for ROS production. And the conduction and valence band potentials of Ag/BMO NPs were favorable for the reduction of O2 to ·O2−. Under 1064 nm laser irradiation, the electron transfer to BMO was beneficial to the reversible change of Mo5+/Mo6+, further improving the peroxidase-like catalytic activity and NIR-II photodynamic performance based on the Russell mechanism. In vivo, the Ag/BMO NPs exhibited promising therapeutic effects towards MRSA-infected wounds. This study enriches the nanozyme research and proves that nanozymes can be rationally optimized by charge separation engineering strategy.

show abstract

A versatile chitosan nanogel capable of generating AgNPs in-situ and long-acting slow-release of Ag+ for highly efficient antibacterial

Cited by 44 publications

References 37 publications

Ag Nanoparticles for Biomedical Applications—Synthesis and Characterization—A Review

Ag Nanoparticles for Biomedical Applications—Synthesis and Characterization—A Review

Construction of multifunctional porcine acellular dermal matrix hydrogel blended with vancomycin for hemorrhage control, antibacterial action, and tissue repair in infected trauma wounds

POD Nanozyme optimized by charge separation engineering for light/pH activated bacteria catalytic/photodynamic therapy

Contact Info

Product

Resources

About