A versatile biomimetic multienzyme cascade nanoplatform based on boronic acid-modified metal–organic framework for colorimetric biosensing

Abstract

The combination of bio- and chemo-catalysts for sequential cascades has received considerable attention in analytical fields because of the regulable catalytic efficiency and selectivity under various physiological conditions. In this...

Fluorescence and colorimetric dual-mode multienzyme cascade nanoplatform based on CuNCs/FeMn-ZIF-8/PCN for detection of sarcosine

“…6B, to confirm this conjecture, catalase (CAT) was added to the multienzyme cascade system to consume H 2 O 2 without compromising the direct channel of H 2 O 2 from SOX to CuNCs/FeMn-ZIF-8/PCN. 59 With the increased CAT concentration, almost no oxTMB was generated in the free enzyme combination, implying that the intermediate H 2 O 2 was indeed present. On the contrary, incorporating CAT into CuNCs/SOX@FeMn-ZIF-8/PCN did not wholly inhibit oxTMB generation, suggesting that the open diffusion channel improved cascade efficiency.…”

Yolk–Shell and Hollow Zr/Ce-UiO-66 for Manipulating Selectivity in Tandem Reactions and Photoreactions

“…One of the recent advances is to hierarchically combine metal− organic framework (MOF) microcrystals to form hybrid composites, 1−3 such as core−shell MOF, 4−7 yolk−shell MOF, 8,9 single-shelled, 10−14 and multiple-shelled hollow structures. 15−18 The structure of MOF hybrid composites can be finely tuned on molecular, 19−23 mesoscopic, 24 and macroscopic scales, 25 which facilitated remarkable potential for a variety of applications. 26−28 The predesigned spatial positioning of different components in MOF hybrid composites could endow them with enhanced properties and may overcome their weaknesses.…”

“…One of the recent advances is to hierarchically combine metal–organic framework (MOF) microcrystals to form hybrid composites, − such as core–shell MOF, − yolk–shell MOF, , single-shelled, − and multiple-shelled hollow structures. − The structure of MOF hybrid composites can be finely tuned on molecular, − mesoscopic, and macroscopic scales, which facilitated remarkable potential for a variety of applications. − The predesigned spatial positioning of different components in MOF hybrid composites could endow them with enhanced properties and may overcome their weaknesses. − For example, the yolk–shell MOF heterostructures have been paid great interest since the yolk and shell layers may exhibit distinct properties, and they can be further fabricated into hollow structures . The robust shell not only served as a protective layer to enhance the stability of hybrid composites but also facilitated the yolk with substrate and product selectivity properties, thereby realizing selective catalysis .…”

A self-cascade system based on Ag nanoparticle/single-walled carbon nanotube nanocomposites as an enzyme mimic for ultrasensitive detection of l-cysteine

“…To overcome this disadvantage, many efforts have been made to investigate nanomaterials featuring multi-enzyme-mimicking activities. For example, based on the synthesized nanozyme MIL-100(Fe)-BA with oxidase/peroxidase activities, Shen et al 29 established a cascade reaction system for the detection of glutathione and ascorbic acid. Liu et al 30 reported that wool-ball-like copper sulfide (WBLCS) can catalyze the oxidation of cysteine by oxygen to produce cystine and hydrogen peroxide.…”