A Verification of Treatment Protocol in Fractionated Radiotherapy by Biological Dosimetry

Abstract

In radiation therapy of cancer, any possible mistakes that may occur in prescribed tumour dose calculation and/ or in treatment set up could also be checked by the biological dosimetry. In order to verify this, 20 patients having pelvic area tumours with no prescribed chemotherapy were selected. Their peripheral blood samples were collected before starting fractionated radiotherapy and at some definite time during treatment. Equivalent whole body doses (EWBD) were calculated from patient's weights, irradiated volumes and total tumor doses given until the date of blood sample collection during treatment. Each patient's EWBD was given in vitro to blood samples that were collected before starting radiotherapy. Radiation induced chromosome damage in lymphocytes were measured by micronucleus (MN) induction.

Pharmacogenomics- Personalized Treatment of Cancer, Diabetes and Cardiovascular Diseases

“…Both local and systemic treatments are employed for women with primary invasive breast cancer [23]. Local treatments, which include surgery and radiation therapy [24,25], are used to reduce the risk of recurrent cancer in the breast, chest wall and regional lymph nodes. Surgery remains the most common modality for most breast cancers.…”