A variation in Bone Alkaline Phosphatase levels that correlates positively with bone loss and normal levels of aminoterminal propeptide of collagen I in girls with anorexia nervosa

Calero, Jesús Alberto; Múñoz, María Teresa; Argente, Jesús; Traba, M. L.; Méndez-Dávila, Cioly; García-Moreno, Carmen; Piedra, Concepción de la

doi:10.1016/s0009-8981(99)00114-x

Cited by 18 publications

(9 citation statements)

References 11 publications

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“…We found a significant correlation between OPG/RANKL and BMD in group I of AN patients at the beginning of the study. These results are in concordance with a previous study where we reported an increase in bone resorption, as determined by measurement of the b-isomer of urinary carboxyterminal telopeptide of collagen I (b-CTX), a marker of bone resorption in patients with AN [15].…”

Section: Discussionsupporting

confidence: 93%

Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa

Muñoz-Calvo¹,

Barrios²,

Álvaro³

et al. 2007

Scandinavian Journal of Clinical and Laboratory Investigation

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Section: Discussionsupporting

confidence: 93%

Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa

Muñoz-Calvo¹,

Barrios²,

Álvaro³

et al. 2007

Scandinavian Journal of Clinical and Laboratory Investigation

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“…Studies from our group have demonstrated that serum levels of bAP are directly correlated with the degree of osteopenia, with no correlation between PNIP and osteopenia (112). It is interesting to note that we did not find differences in serum bAP levels between patients with AN and controls.…”

Section: Bone Mineral Density and Bone Markerscontrasting

confidence: 52%

Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances

Argente

2002

European Journal of Endocrinology

145

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Anorexia nervosa (AN) is a chronic childhood psychiatric illness that involves a reduction in caloric intake, loss of weight and amenorrhea, either primary or secondary. The diagnostic criteria for AN have been established by the American Psychiatric Association. The prevalence of this disease amongst adolescents and young adults is between 0.5 and 1% and the incidence of new cases per year is approximately 5-10/100 000 between 15 and 19 years of age. A number of endocrine and metabolic disturbances have been described in patients with AN including amenorrhea-oligomenorrhea, delayed puberty, hypothyroidism, hypercortisolism, IGF-I deficiency, electrolyte abnormalities, hypoglycemia and hypophosphatemia, among others. In addition to prolonged amenorrhea, osteopenia and osteoporosis are the most frequent complications leading to clinically relevant fractures and increased fracture risk throughout life. Patients exhibit an alteration in the hypothalamic -pituitary -gonadal axis, which is responsible for the menstrual disorders. The increase in gonadotropin secretion that can be observed after ponderal recuperation suggests that malnutrition could be the most important mechanism involved in the decrease in gonadotropin secretion. The loss of fat tissue as a consequence of nutrient restriction has been associated with hypoleptinemia and abnormal secretion of peptides implicated in food control (neuropeptide Y, melanocortins and corticotropin-releasing factor, among others). A review of the endocrine abnormalities, disturbances in neurotransmitters, as well as a detailed analysis of bone markers and bone mineral density in patients with AN is described.

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“…Studies from our group have demonstrated that serum levels of bAP are directly correlated with the degree of osteopenia, with no correlation between PNIP and osteopenia [42]. It is interesting to note that we did not find differences in serum bAP levels between patients with AN and controls.…”

Section: Bone Mineral Density and Bone Markerscontrasting

confidence: 52%

Anorexia nervosa: Hypogonadotrophic Hypogonadism and Bone Mineral Density

Múñoz¹,

Argente²

2002

Horm Res Paediatr

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A variation in Bone Alkaline Phosphatase levels that correlates positively with bone loss and normal levels of aminoterminal propeptide of collagen I in girls with anorexia nervosa

Cited by 18 publications

References 11 publications

Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa

Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa

Anorexia nervosa in female adolescents: endocrine and bone mineral density disturbances

Anorexia nervosa: Hypogonadotrophic Hypogonadism and Bone Mineral Density

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