Maintained malnutrition produces a progressive decrease in (OPG)/RANKL ratio and leptin levels in patients with anorexia nervosa

Abstract

The decrease in the OPG/RANKL ratio in girls with AN could partly explain the increase in bone loss that occurs in these patients.

Metabolizm kostny, osteoprotegeryna i ligand receptora aktywatora czynnika jądrowego-kB a wybrane hormony tkanki tłuszczowej u dziewcząt z jadłowstrętem psychicznym

“…Our earlier investigations revealed that serum sRANKL was increased while the OPG/sRANKL ratio was significantly decreased [21,22,61]. Similar results were obtained by Munoz-Calvo et al [57]. However, no complex research studies have been carried out so far in girls with AN concerning the relationships between LP, ADIPO, RES, VISF, APE-36, APE-12 and bone metabolism, OPG and its soluble ligand sRANKL.…”

“…Munoz-Calvo et al [57] also reported a significant decrease in the OPG/RANKL ratio correlated with an increase in serum RANKL as well as a positive and significant correlation between the OPG/RANKL ratio and BMD. However, they did not observe a significant OPG increase in serum of girls with AN, or any relationships between OPG, RANKL and BMD.…”

“…However, it should be emphasised that Misra et al [4] did not investigate the levels of RANKL and the values of the OPG/sRANKL ratio. Munoz-Calvo et al [57] and Ostrowska et al [21,22,61] determined serum OPG and sRANKL in female adolescents with AN and revealed significant suppression of the OPG/sRANKL ratio in patients with normal [57] or significantly increased OPG levels [21,22,61] and significantly increased sRANKL [21,22,57,61].…”

“…However, they did not observe a significant OPG increase in serum of girls with AN, or any relationships between OPG, RANKL and BMD. According to Munoz-Calvo et al [57], the decrease in the OPG/RANKL ratio in girls with AN only partly explains increased bone loss observed in these patients. It has been well established that 17b-oestradiol is the major regulator of bone metabolism and BMD in both women and girls suffering from AN.…”

TGF-β1, metabolizm kostny, osteoprotegeryna i rozpuszczalny ligand receptora aktywatora czynnika jądrowego-B u dziewcząt z jadłowstrętem psychicznym

“…On the other hand, serum sRANKL [25][26][27][28][29][30][31] and/or OPG levels [23][24][25][26][27][28][29][30][31] are significantly increased in girls with AN while the OPG/sRANKL ratio is significantly decreased [32,[25][26][27][28][29][30][31]. MunozCalvo et al [32] were the only researchers who did not find significant changes in OPG levels in girls with AN who exhibited a significantly increased sRANKL level and OPG/sRANKL suppression. Our previous studies [26][27][28][29][30][31] indicate some desynchronisation between the RANKL/RANK/OPG system and bone remodelling (especially bone resorption) in girls with AN.…”