A validation of DCIS registration in a population-based breast cancer quality register and a study of treatment and prognosis for DCIS during 20 years

Wadsten, Charlotta; Heyman, Hanna; Holmqvist, Marit; Ahlgren, Johan; Lambe, Mats; Sund, Malin; Wärnberg, Fredrik

doi:10.1080/0284186x.2016.1211317

Cited by 16 publications

(17 citation statements)

References 23 publications

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“…In this setting, several alternatives have been reported. Another potential benefit of SentiNot is that, if no SLND has been performed originally, in the event of recurrence the axilla is still unoperated. The morbidity and complications of SLND in women with DCIS have been well described; in a Surveillance, Epidemiology and End Results Program data set analysis it was associated with complications including lymphoedema, wound infection, seroma and pain within 9 months of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Effect of preoperative injection of superparamagnetic iron oxide particles on rates of sentinel lymph node dissection in women undergoing surgery for ductal carcinoma in situ (SentiNot study)

Karakatsanis

Hersi

Pistioli

et al. 2019

British Journal of Surgery

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Background: One-fifth of patients with a preoperative diagnosis of ductal carcinoma in situ (DCIS) have invasive breast cancer (IBC) on definitive histology. Sentinel lymph node dissection (SLND) is performed in almost half of women having surgery for DCIS in Sweden. The aim of the present study was to try to minimize unnecessary SLND by injecting superparamagnetic iron oxide (SPIO) nanoparticles at the time of primary breast surgery, enabling SLND to be performed later, if IBC is found in the primary specimen.Methods: Women with DCIS at high risk for the presence of invasion undergoing breast conservation, and patients with DCIS undergoing mastectomy were included. The primary outcome was whether this technique could reduce SLND. Secondary outcomes were number of SLNDs avoided, detection rate and procedure-related costs.Results: This was a preplanned interim analysis of 189 procedures. IBC was found in 47 and a secondary SLND was performed in 41 women. Thus, 78⋅3 per cent of patients avoided SLND (P < 0⋅001). At reoperation, SPIO plus blue dye outperformed isotope and blue dye in detection of the sentinel node (40 of 40 versus 26 of 40 women; P < 0⋅001). Costs were reduced by a mean of 24⋅5 per cent in women without IBC (€3990 versus 5286; P < 0⋅001).Conclusion: Marking the sentinel node with SPIO in women having surgery for DCIS was effective at avoiding unnecessary SLND in this study. Registration number: ISRCTN18430240

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Section: Discussionmentioning

confidence: 99%

Effect of preoperative injection of superparamagnetic iron oxide particles on rates of sentinel lymph node dissection in women undergoing surgery for ductal carcinoma in situ (SentiNot study)

Karakatsanis

Hersi

Pistioli

et al. 2019

British Journal of Surgery

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“…Another limitation is that as with all register studies, some misclassifications may be present. A validation of the BC register revealed that 7% of the women with registered DCIS actually had an invasive breast cancer [5]. However, there is no reason to believe that this would differ by laterality or that this low number would influence overall results.…”

Section: Discussionmentioning

confidence: 99%

“…The use of adjuvant radiotherapy (RT) in the management of ductal carcinoma in situ (DCIS) has increased substantially over the last decades [1][2][3][4][5]. Four randomised trials have demonstrated that the addition of postoperative RT after breast conserving surgery (BCS) reduces ipsilateral breast events by half compared to surgery alone, but survival benefits remain uncertain [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Risk of ischemic heart disease after radiotherapy for ductal carcinoma in situ

Wadsten

Wennstig

Garmo

et al. 2018

Breast Cancer Res Treat

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“…Another register validation study covering roughly the same geographical area as the register validated here was performed by Wadsten et al (13), concerning registration of ductal carcinoma in situ in a breast cancer quality register. The study found that the proportion of correct baseline values for individual variables ranged from 92% to 99%, but that the situation was considerably worse for registration of recurrences, where only 65% of actual recurrences had been reported to the register.…”

Section: Discussionmentioning

confidence: 99%

Validation of a Clinical Cancer Register at the Head and Neck Oncology Center in Örebro

et al. 2018

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Background: This was a validation study of a regional register of oral cancer in Örebro, Sweden. The purpose was to assess the rate of errors in baseline, and treatment, and the completeness and accuracy of data on recurrences. Materials and Methods: A total of 653 cases with squamous cell cancer in the oral cavity were identified from the register. A randomized sample of 73 (11%) was selected, and a set of relevant data was compared to medical records. Results: Data on patient and tumour characteristics showed high accuracy, with 98% correct data and more than 99% of treatment data were correct. Follow-up data had a higher rate of errors, with 23% of recurrences not recorded, 13.6% misclassified, and 9.1% of cases showing errors in timing of the recurrence. Conclusion: data concerning patients, tumour status, and treatment in the Regional Head and Neck Register in Örebro are highly accurate. However, the follow-up data contain a higher rate of errors, that must be taken into consideration when evaluating outcome after treatment.

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A validation of DCIS registration in a population-based breast cancer quality register and a study of treatment and prognosis for DCIS during 20 years

Cited by 16 publications

References 23 publications

Effect of preoperative injection of superparamagnetic iron oxide particles on rates of sentinel lymph node dissection in women undergoing surgery for ductal carcinoma in situ (SentiNot study)

Effect of preoperative injection of superparamagnetic iron oxide particles on rates of sentinel lymph node dissection in women undergoing surgery for ductal carcinoma in situ (SentiNot study)

Risk of ischemic heart disease after radiotherapy for ductal carcinoma in situ

Validation of a Clinical Cancer Register at the Head and Neck Oncology Center in Örebro

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