A validated UHPLC-MS/MS method for simultaneous quantification of some repurposed COVID-19 drugs in rat plasma: Application to a pharmacokinetic study

Azab, Noha F. El

doi:10.1016/j.microc.2022.107321

Cited by 11 publications

(2 citation statements)

References 30 publications

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“…Several chromatographic [3] , [4] , [5] , [6] , spectrophotometric [4] , [7] and voltammetric methods [8] have been reported for (RDS) analysis. However, to the best of our knowledge, no potentiometric methods have been developed yet for (RDS).…”

Section: Introductionmentioning

confidence: 99%

Solid-state ion-selective electrodes for the first potentiometric determination of the anti-COVID 19 drug Remdesivir in human plasma; A comparative study

Azab

Ahmed

2023

Microchemical Journal

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Section: Introductionmentioning

confidence: 99%

Solid-state ion-selective electrodes for the first potentiometric determination of the anti-COVID 19 drug Remdesivir in human plasma; A comparative study

Azab

Ahmed

2023

Microchemical Journal

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“…This expanded the arsenal of already existing methods for overcoming viral resistance to antiviral drugs (mutation H275Y responsible for drug resistance to OST appeared only for monotherapy). The combination of OST with hydroxychloroquine turned out to be more effective as antiviral therapy with respect to the duration of treatment of COVID-19 patients [8]. However, numerous deleterious necrotic and fibrotic histopathological changes in Pharmaceutical Chemistry Journal, Vol.…”

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confidence: 99%

Determination of Oseltamivir in Human Plasma by HPLC-MS/MS

et al. 2023

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A procedure for the determination of oseltamivir in human plasma by high-performance liquid chromatography( tandem mass spectrometry (HPLC-MS/MS) was proposed and validated. Arapid and easy-to-use method of liquid(liquid extraction with ethyl acetate using venlafaxine as an internal standard was used during sample preparation. The addition of benzoic acid to aqueous acetonitrile solutions of the analyte was shown to prevent its oxidative degradation. The detection limit and limit of quantitation were 0.08 and 0.30 ng/mL, respectively; the calibration range, 0.3-200 ng/mL ( R 2 = 0.9937); the total analysis time, 3.2 min. The within- and between-run accuracy ranged from 97 to 105%. The precision was <10%. The proposed procedure was characterized by selective determination of the analyte, the absence of significant matrix effects, the ability to dilute samples with high analyte concentrations, and satisfactory extraction recovery (≥89%). The analyte was stable when stored in plasma samples (4 h at room temperature, 31 d at (80°C, after three freeze(thaw cycles) and extracts under autosampler storage conditions (24 h at 15°C). The procedure was successfully used for oseltamivir quantitation in actual plasma samples from healthy volunteers obtained during a bioequivalence study of the new generic drug.

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Simple determination of dichlorvos in cases of fatal intoxication by gas Chromatography-Mass spectrometry

Jain

Chauhan

et al. 2023

Journal of Chromatography B

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A validated UHPLC-MS/MS method for simultaneous quantification of some repurposed COVID-19 drugs in rat plasma: Application to a pharmacokinetic study

Cited by 11 publications

References 30 publications

Solid-state ion-selective electrodes for the first potentiometric determination of the anti-COVID 19 drug Remdesivir in human plasma; A comparative study

Solid-state ion-selective electrodes for the first potentiometric determination of the anti-COVID 19 drug Remdesivir in human plasma; A comparative study

Determination of Oseltamivir in Human Plasma by HPLC-MS/MS

Simple determination of dichlorvos in cases of fatal intoxication by gas Chromatography-Mass spectrometry

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