A validated method for the rapid quantification of melatonin in over-the-counter hypnotics by the atmospheric pressure solid analysis probe (ASAP)

Abstract

Melatonin is a hormone that regulates the biological day and night cycle.

Applications of ambient ionization mass spectrometry in 2022: An annual review

“…ASAP has also been utilized for the rapid characterization of medicinal products. A recent study demonstrated its utility in quantifying the amount of melatonin, a hormone commonly used to facilitate sleep, in over‐the‐counter medicines, comparing the results with a standard LC‐MS method with equivalent results 111 . The technique was similarly used to measure sildenafil, more commonly known as Viagra, in herbal medicines promising to treat erectile dysfunction, demonstrating the variation in the presence and abundance of the active ingredient in 12 different medicines purchased online 112 .…”

Unveiling the Collaborative Effect at the Cucurbit[8]uril‐MoS2 Hybrid Interface for Electrochemical Melatonin Determination

“…MLT is of paramount significance in organisms since it regulates circadian rhythms and blood pressure, acts as antioxidant and anti‐inflammatory agent, and is a free radical scavenger playing therefore, an important role in cell protection [12–14] . Such a wide scope has made that recent applications are focused on MLT analysis in food, [15–17] pharmaceutical [16–18] or biological samples as urine, saliva and nails [19–22] . Therefore, various analytical methods have been developed for MLT quantification.…”

“…[ 12 , 13 , 14 ] Such a wide scope has made that recent applications are focused on MLT analysis in food,[ 15 , 16 , 17 ] pharmaceutical[ 16 , 17 , 18 ] or biological samples as urine, saliva and nails. [ 19 , 20 , 21 , 22 ] Therefore, various analytical methods have been developed for MLT quantification. Although different chromatographic techniques with UV‐vis, [18] fluorescence [15] or mass spectrometry detection [21] have been proposed, electrochemical methods result an interesting alternative to these expensive and sophisticated techniques.…”

“…[ 19 , 20 , 21 , 22 ] Therefore, various analytical methods have been developed for MLT quantification. Although different chromatographic techniques with UV‐vis, [18] fluorescence [15] or mass spectrometry detection [21] have been proposed, electrochemical methods result an interesting alternative to these expensive and sophisticated techniques. In contrast, the electrochemical ones offer a high sensitivity with cheaper and simpler instrumentation.…”

Selectivity of Explosives Analysis with Ambient Ionization Single Quadrupole Mass Spectrometry: Implications for Trace Detection

“…Although these publications contain many examples of use of AI-MS, understanding the advantages and limitations for specific techniques is challenging due to the often “homemade” setups, differences in experimental design, and mass spectrometers used. Several validation studies have been carried out, − including the British Mass Spectrometry Society (BMSS) interlaboratory study, demonstrating the potential for AI as a tool for routine analysis and addressing usual analytical concerns like robustness, reproducibility and matrix effects. The BMSS interlaboratory study concluded that ambient ionization techniques are able to ionize a range of compounds/molecules with good precision and repeatability when care is taken with the experimental set up and that the data produced can be improved significantly with an appropriate internal standard.…”