2009
DOI: 10.1590/s0102-695x2009000200007
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A validated capillary gas chromatography method for guaco (Mikania glomerata S.) quality control and rastreability: from plant biomass to phytomedicines

Abstract: A validated capillary gas chromatography method for guaco (Mikania glomerata S.) quality control and rastreability: from plant biomass to phytomedicines ABSTRACT: This work describes a full validation of a capillary gas chromatography analytical methodology using internal standardization for the quantification of coumarin (1,2-benzopyrone) in guaco (Mikania glomerata Spreng -Asteraceae) products: syrup, plant and its extract, including the stability study of the phytomedicine. For the analysis, it was used an … Show more

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Cited by 12 publications
(13 citation statements)
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References 30 publications
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“…O gênero Mikania contém cerca de 300 espécies as quais são usadas em medicina popular (Agra et al, 2007;. O estudo fitoquímico de diversas espécies de Mikania conduziu ao isolamento de monoterpenos, lactonas sesquiterpênicas, diterpenos e cumarinas (Christo et al, 2006;Reis et al, 2008;Bolina et al, 2009;Bueno & Bastos, 2009).…”
unclassified
“…O gênero Mikania contém cerca de 300 espécies as quais são usadas em medicina popular (Agra et al, 2007;. O estudo fitoquímico de diversas espécies de Mikania conduziu ao isolamento de monoterpenos, lactonas sesquiterpênicas, diterpenos e cumarinas (Christo et al, 2006;Reis et al, 2008;Bolina et al, 2009;Bueno & Bastos, 2009).…”
unclassified
“…Análises de controle de qualidade de matérias-primas vegetais e do fitoterápico são complexas, porém imprescindíveis para contribuir para a qualidade do medicamento (Ushirobira et al, 2004b;Bara et al, 2004;Bara et al, 2006;Chaves & Costa 2008;Engel et al, 2008;Paula et al, 2008;Alvarenga et al, 2009;Bueno & Bastos, 2009;Couto et al, 2009).…”
Section: Resultsunclassified
“…Thus, using different analytical procedures, the presence of a large number of compounds has been described, including stigmasterol, phytol, 1-ethoxy-1-phenylethanol, 4-hydroxy-3,5-dimethoxybenzaldehyde, hexanoic acid, ethyl hexadecanoate, ethyl linoleoate, kaurenol, an isomer of kaurenoic acid, spathulenol, hexadecanoic acid, 9,12,15-octadecatrienoic acid, cupressenic acid, isopropiloxigrandifloric acid, 2-5-ciclohexadiene-1,4-dione,2,6-bis, 1-octadecene, octadecanoic acid, ester diterpenic, caryophyllene oxide, 10, 13-octadecadienoic acid, isobutiloxigrandifloric acid, trans-cariofileno, 8,11-octadecadienoic acid, lupeol, lupeol www.intechopen.com Toxicity and Drug Testing 300 acetate, benzoylgrandifloric and cinnamoylgrandifloric acids (Oliveira et al, 1993;Moura et al, 2002;Biavatti et al, 2004;Santos, 2005;Yatsuda et al, 2005;Bertolucci et al, 2008;Alves et al, 2009;Bolina et al, 2009;Muceneeki et al, 2009). In quantitative terms, the most prevalent metabolites of hydroalcoholic extracts are coumarin (1,2-benzopyrone) (Biavatti et al, 2004;Bueno & Bastos, 2009), o-coumaric acid (Santos, 2005), dihydrocoumarin (Alves et al, 2009), syringaldehyde (Muceneeki et al, 2009) and kaurenoic acid (Vilegas et al, 1997a;Vilegas et al, 1997b;Yatsuda et al, 2005;Bertolucci et al, 2008). These substances have been associated with the therapeutic effects of guaco because they have anti-inflammatory and bronchodilator properties.…”
Section: Chemical Constituentsmentioning
confidence: 99%