“…Introduced in the field of sequence analysis more than 20 years ago [26], mutidimensional scaling analysis was applied to the analysis of protein families [26], [27], [28], [29], [30], of the protein fold space [31], [32], [33], of virus evolution [34], [35], [36], [37] and of large genomic data sets [38]. This method usefully complements phylogenetic techniques and provides important insights into the evolution of proteins, genes and virus.…”