A Universidade de Coimbra: o tangível e o intangível

Castro, Aníbal Pinto de; Lobo, Lélio Quaresma; Santos, Maria José Azevedo; Coelho, María Helena da Cruz; Costa, José de Faria; Serrão, Vítor

doi:10.14195/978-989-26-0164-9

Cited by 6 publications

(6 citation statements)

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“…2D) and cleavage of PARP ( Fig. 3) indicate that Hsp90 inhibition by GA induces the mitochondria-mediated apoptotic pathway, in line with other studies using GA in a variety of cell lines [29][30][31][32]. Furthermore, GA treatment resulted in the downregulation of both the native NPM-ALK and phospho-NPM-ALK ( Fig.…”

Section: Discussionsupporting

confidence: 85%

Proteome‐wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells

et al. 2007

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The molecular chaperone heat shock protein 90 (Hsp90) affects the function of many oncogenic signaling proteins including nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expressed in anaplastic large cell lymphoma (ALCL). While ALK-positive ALCL cells are sensitive to the Hsp90 inhibitor and the geldanamycin (GA) analog, 17-allylamino-17-demethoxygeldanamycin (17-AAG), the proteomic effects of these drugs on ALK-positive ALCL cells are unpublished. In this study, we investigated the cellular, biologic, and proteomic changes occurring in ALK-positive ALCL cells in response to GA treatment. GA induced G2/M cell cycle arrest and caspase-3-mediated apoptosis. Furthermore, quantitative proteomic changes analyzed by cleavable isotope-coded affinity tag-LC-MS/MS (cICAT-LC-MS/MS) identified 176 differentially expressed proteins. Out of these, 49 were upregulated 1.5-fold or greater and 70 were downregulated 1.5-fold or greater in GA-treated cells. Analysis of biological functions of differentially expressed proteins revealed diverse changes, including induction of proteins involved in the 26S proteasome as well as downregulation of proteins involved in signal transduction and protein and nucleic acid metabolism. Pathway analysis revealed changes in MAPK, WNT, NF-kappaB, TGFbeta, PPAR, and integrin signaling components. Our studies reveal some of the molecular and proteomic consequences of Hsp90 inhibition in ALK-positive ALCL cells and provide novel insights into the mechanisms of its diverse cellular effects.

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Section: Discussionsupporting

confidence: 85%

Proteome‐wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells

et al. 2007

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“…8 are qualitatively similar to earlier attempts to fit STS data by assuming a model self-energy dressing a BCS-like d-wave Green's function. In particular, Hoogenboom et al [43] and de Castro et al [44] compared data on BSCCO to self-energy models with constant scattering rates, a marginal Fermi liquid model [45], and the model of Ref. [38] describing a coupling to a phenomenological collective spin mode.…”

Section: Local Green's Functionmentioning

confidence: 99%

“…8 shows, as in Refs. [43,44], the broadening of the van Hove singularity by inelastic scattering, and that out-of-plane elastic scattering may play a role as well. Peak-dip-hump structures similar to experiment are seen in some cases in Fig.…”

Section: Local Green's Functionmentioning

confidence: 99%

Local quasiparticle lifetimes in ad-wave superconductor

2008

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Scanning tunnelling spectroscopy (STS) measurements find that the surface of Bi-2212 is characterized by nanoscale sized regions, "gap patches," which have different magnitudes for the d-wave energy gap ∆0(r). Recent studies have shown that the tunnelling conductance can be fit using a BCS-type density of states for a d-wave superconductor with a local quasiparticle scattering rate. The fit is made with a scattering rate which varies linearly with energy and has a slope α(r) that is positively correlated with the local value of the gap. We consider first the question of what is actually measured in such an experiment. To this end we revisit a model of quasiparticle scattering by impurities and spin fluctuations which was previously used to describe the lifetimes of nodal quasiparticles measured by angle-resolved photoemission (ARPES). We argue that the broadening of the local density of states is determined, except in the case of localized impurity bound states, by the imaginary part of the self-energy of the system averaged over a small region. The size of this region is set by a mean free path which depends upon the energy. At low energies, this region is found to be significantly larger than a gap "patch", so that the density of states measured by STS is homogeneous in this energy range. At higher energies where the mean free path is comparable with the patch size, the density of states is inhomogeneous. We show that a local self-energy in the impurity-plus-spin fluctuation model, while not strictly linear, yields a local density of states (LDOS) nearly identical to the full theory, and argue that it is consistent with the STS data as well as the phenomenological linear scattering rate extracted from experiment. We also explore the qualitative consequences of this phenomenology for the spectral widths observed in ARPES and predict the existence of Fermi arcs in the superconducting state.

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“…Este procedimiento también podría resultar útil para el control parasitario en especies animales que se crían en régimen ecológico (Ortiz Pérez y cols., 2017). Agroecologia 67,89,97,98,99,100,101,104,106,107,108 B Bioclimatologia animal 152,153,164,165 Bioflocos 138,139,142,143,145,146,147 C Caballos 167,168,169,170,171,172,173,174,175 Cangrejo de río 130 Capsicum 1,2,3,4,6,7,9,10,13 Centla 130,131,132 Ciclo PDCA 116,122,123,126 Control biológico 167…”

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“…L 24,25,33,36 Leite 97,102,106,116,117,118,119,121,124,125,126,128,129,154,164,165 Lucratividade e cultivares 33 M Meio ambiente 24,36,58,89,93,99,100,102,121,124,147 Mudança climática 152,153,154,155,158,159,161,163 P Patologia de Sementes 71,73 Pecuária 63,71,78,91,116,127,128 Pellets 167,168,174,175,176 Pennisetum purpureum 109,110,112 Pesca 130 Piscicultura 138,140,150,151 Plantas inseticidas 24…”

mentioning

confidence: 99%