A universal biosensing platform based on optical micro-ring resonators

Ramachandran, Akhilesh; Wang, S.; Clarke, Jim; Ja, Shiou Jyh; Goad, David; Wald, Lara; Flood, E.; Knobbe, Edward T.; Hryniewicz, J.V.; Chu, Sai T.; Gill, D.; Chen, W.; King, O.; Little, Brent E.

doi:10.1016/j.bios.2007.09.007

Cited by 211 publications

(147 citation statements)

References 22 publications

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“…One type of integrated optical sensor, that has recently been under intense investigation for on-chip label-free detection, is the planar waveguide ring resonator. [2][3][4][5] Due to its small footprint and ease of integration with other on-chip optical and fluidic functions, the ring resonator is a particularly interesting optical sensor for labs-on-chips.…”

Section: Integration Of Multiple Sensors For Parallel Operation and Omentioning

confidence: 99%

A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

et al. 2010

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We present the design, fabrication, and characterisation of an array of optical slot-waveguide ring resonator sensors, integrated with microfluidic sample handling in a compact cartridge, for multiplexed real-time label-free biosensing. Multiplexing not only enables high throughput, but also provides reference channels for drift compensation and control experiments. Our use of alignment tolerant surface gratings to couple light into the optical chip enables quick replacement of cartridges in the read-out instrument. Furthermore, our novel use of a dual surface-energy adhesive film to bond a hard plastic shell directly to the PDMS microfluidic network allows for fast and leak-tight assembly of compact cartridges with tightly spaced fluidic interconnects. The high sensitivity of the slot-waveguide resonators, combined with on-chip referencing and physical modelling, yields a volume refractive index detection limit of 5 x 10(-6) refractive index units (RIUs) and a surface mass density detection limit of 0.9 pg mm(-2), to our knowledge the best reported values for integrated planar ring resonators.

QC 20100715

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Section: Integration Of Multiple Sensors For Parallel Operation and Omentioning

confidence: 99%

A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

et al. 2010

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QC 20100715

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“…3,4 MRs based on integrated optical waveguides possess promising performances, particularly thanks to their integration capability with electronic devices as well as photonic devices, and to their easy fabrication with mature semiconductor processing technologies. [5][6][7] Moreover, these sensors allow label-free detection, compatibility with micro-fluidic handling and capability of providing high specificity using surface chemical modifications. 8,9 They can be easily implemented using polymer materials with a low cost of fabrication.…”

Section: Introductionmentioning

confidence: 99%

Integrated polymer micro-ring resonators for optical sensing applications

Girault

Lorrain

Poffo

et al. 2015

Journal of Applied Physics

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Micro-resonators (MR) have become a key element for integrated optical sensors due to their integration capability and their easy fabrication with low cost polymer materials.Nowadays, there is a growing need on MRs as highly sensitive and selective functions especially in the areas of food and health. The context of this work is to implement and study integrated micro-ring resonators devoted to sensing applications. They are fabricated by processing SU8 polymer as core layer and PMATRIFE polymer as lower cladding layer. The refractive index of the polymers and of the waveguide structure as a function of the wavelength are presented. Using these results, a theoretical study of the coupling between ring and straight waveguides has been undertaken in order to define the MR design. Sub-micronic gaps of 0.5 µm to 1 µm between the ring and the straight waveguides have been successfully achieved with UV (i-lines) photolithography. Different superstrates such as air, water and aqueous solutions with glucose at different concentrations have been studied. First results show a good normalized transmission contrast of 0.98, a resonator quality factor around 1.5x10 4 corresponding to a coupling ratio of 14.7 % and ring propagation losses around 5 dB/cm.Preliminary sensing experiments have been performed for different concentrations of glucose; a sensitivity of 115 ± 8 nm/RIU at 1550 nm has been obtained with this couple of polymers.

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“…(4)(5)(6)(7)(8)(9)(10)(11) In addition, microring resonator (MRR)-based biosensors have also been intensively developed because of their compactness, high sensitivity, and low cost. (12)(13)(14)(15)(16)(17)(18)(19)(20) We have also proposed and developed a biosensor based on an MRR-loaded Mach-Zehnder interferometer (MRR-MZI) (21) that has a higher sensitivity than conventional MRR sensors. Although avidin at a concentration as low as 20 pM was detected as a change in light transmittance with the MRR-MZI sensor, a sufficient change in transmittance has not yet been obtained.…”

Section: Introductionmentioning

confidence: 99%

Improved Sensitivity of Microring Resonator-Loaded Mach–Zehnder Interferometer Biosensor

2017

Sensors and Materials

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We investigated the improvement in the sensitivity of a biosensor based on a silicon microring resonator-loaded Mach-Zehnder interferometer (MRR-MZI). Thermo-optic-driven variable optical attenuators (VOAs) were used to balance the optical power in one arm with that in the other to obtain a high extinction ratio of the MRR-MZI. The change in the transmittance as large as 12.9 and 7.5 dB for the detection of 200 and 20 pM avidin, respectively, was successfully obtained. These values are larger than those observed before the adjustment of the optical power balance by 4.8 and 5.3 dB, respectively. We discuss the characteristics of light power adjustment of the VOA and confirmation of biotin modification of the surface of the silicon waveguide using fluoresceinpolyethylene glycol-N-hydroxylsuccinimide (fluorescein-PEG-NHS).

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A universal biosensing platform based on optical micro-ring resonators

Cited by 211 publications

References 22 publications

A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

Integrated polymer micro-ring resonators for optical sensing applications

Improved Sensitivity of Microring Resonator-Loaded Mach–Zehnder Interferometer Biosensor

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A universal biosensing platform based on optical micro-ring resonators

Cited by 211 publications

References 22 publications

A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

A packaged optical slot-waveguide ring resonator sensor array for multiplex label-free assays in labs-on-chips

Integrated polymer micro-ring resonators for optical sensing applications

Improved Sensitivity of Microring Resonator-Loaded Mach&ndash;Zehnder Interferometer Biosensor

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Improved Sensitivity of Microring Resonator-Loaded Mach–Zehnder Interferometer Biosensor