A Unique Rapid Enhancement by Adjuvant of Delayed Hypersensitivity to Protein Antigens in the Guinea Pig

Hc, Magüire

doi:10.1159/000230295

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…In experiments with protein antigens, we have noted that the adjuvant effect is not realized if adjuvant is injected far distant from the sensitiza tion site [9]. This principle was demonstrated for simple chemical aller gens in the following cross-over experiment, which also illustrates the specificity of the adjuvant effect.…”

Section: Resultsmentioning

confidence: 82%

“…The susceptibility of tuberculin positive guinea pigs to rapid en hancement of delayed hypersensitivity to protein antigens has been noted [9].…”

Section: Resultsmentioning

confidence: 99%

“…However, it is necessary to select a concentration of allergen that, without adjuvant, sensitizes very weakly [9]. With foreign protein antigens this presents no real difficulty.…”

Section: Discussionmentioning

confidence: 99%

“…In studying the split adjuvant method of sensitization with protein an tigens, it was observed that the enhancing effect of adjuvant could occur quite rapidly [9]. In a typical experiment, a skin site on the flank is inject ed intradermally with 10 fig of ovalbumin, and Freund's complete adju vant injected into the same site, or nearby, on day 4.…”

mentioning

confidence: 99%

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The Rapid Adjuvant Effect in the Acquisition of Delayed Hypersensitivity to Low Molecular Weight Sensitizers in the Guinea Pig

Maguire¹,

Coghlan²

1971

Int Arch Allergy Immunol

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Guinea pigs were substantially sensitized to the low molecular weight chemicals dinitrochlorobenzene (DNCB), paranitrosodimethylaniline (NDMA), Rhus extract and picric acid, by the injection of Freund’s complete adjuvant into a skin site primed several days previously with a borderline sensitizing concentration of the particular chemical. The adjuvant effect may occur in as little as two days. The skin site prepared with allergen need be present only during the early portion of the inductive phase of the hypersensitivity. It appears that enhancement takes place via a quantitative and/or qualitative stimulation of centrally-located clones of cells previously selected by antigen.

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Section: Resultsmentioning

confidence: 82%

“…The susceptibility of tuberculin positive guinea pigs to rapid en hancement of delayed hypersensitivity to protein antigens has been noted [9].…”

Section: Resultsmentioning

confidence: 99%

“…However, it is necessary to select a concentration of allergen that, without adjuvant, sensitizes very weakly [9]. With foreign protein antigens this presents no real difficulty.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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